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BARX1 BARX homeobox 1 [ Homo sapiens (human) ]

Gene ID: 56033, updated on 1-Jun-2020

Summary

Official Symbol
BARX1provided by HGNC
Official Full Name
BARX homeobox 1provided by HGNC
Primary source
HGNC:HGNC:955
See related
Ensembl:ENSG00000131668 MIM:603260
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the Bar subclass of homeobox transcription factors. Studies of the mouse and chick homolog suggest the encoded protein may play a role in developing teeth and craniofacial mesenchyme of neural crest origin. The protein may also be associated with differentiation of stomach epithelia. [provided by RefSeq, Jul 2008]
Expression
Biased expression in stomach (RPKM 5.0), testis (RPKM 0.6) and 1 other tissue See more
Orthologs

Genomic context

See BARX1 in Genome Data Viewer
Location:
9q22.32
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (93951627..93955355, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (96713909..96717608, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene microRNA 4291 Neighboring gene uncharacterized LOC101928014 Neighboring gene BARX1 divergent transcript Neighboring gene protein tyrosine phosphatase domain containing 1 Neighboring gene CYCS pseudogene 24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling IEA
Inferred from Electronic Annotation
more info
 
epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spleen development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
homeobox protein BarH-like 1
Names
BarH-like homeobox 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021570.4NP_067545.3  homeobox protein BarH-like 1

    See identical proteins and their annotated locations for NP_067545.3

    Status: REVIEWED

    Source sequence(s)
    AL357073, BC009458, BC064363
    Consensus CDS
    CCDS35070.2
    UniProtKB/Swiss-Prot
    Q9HBU1
    Related
    ENSP00000253968.5, ENST00000253968.11
    Conserved Domains (1) summary
    pfam00046
    Location:145198
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    93951627..93955355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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