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Nprl2 NPR2 like, GATOR1 complex subunit [ Mus musculus (house mouse) ]

Gene ID: 56032, updated on 12-May-2024

Summary

Official Symbol
Nprl2provided by MGI
Official Full Name
NPR2 like, GATOR1 complex subunitprovided by MGI
Primary source
MGI:MGI:1914482
See related
Ensembl:ENSMUSG00000010057 AllianceGenome:MGI:1914482
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G21; NPR2L; Tusc4; 2810446G01Rik
Summary
Predicted to enable protein kinase activity. Predicted to contribute to GTPase activator activity. Predicted to be involved in several processes, including cellular response to starvation; negative regulation of TOR signaling; and regulation of autophagosome assembly. Predicted to be located in lysosomal membrane. Predicted to be part of GATOR1 complex. Human ortholog(s) of this gene implicated in focal epilepsy. Orthologous to human NPRL2 (NPR2 like, GATOR1 complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 22.0), whole brain E14.5 (RPKM 21.6) and 28 other tissues See more
Orthologs
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Genomic context

See Nprl2 in Genome Data Viewer
Location:
9 F1; 9 58.12 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107419405..107422905)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107542177..107545706)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10583 Neighboring gene transmembrane protein 115 Neighboring gene cytochrome b-561 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E10584 Neighboring gene STARR-positive B cell enhancer ABC_E3857 Neighboring gene zinc finger, MYND domain containing 10 Neighboring gene predicted gene, 34106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107453431-107453584 Neighboring gene Ras association (RalGDS/AF-6) domain family member 1 Neighboring gene STARR-positive B cell enhancer ABC_E9335 Neighboring gene predicted gene 9917

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of GATOR1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of GATOR1 complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
GATOR1 complex protein NPRL2
Names
GATOR complex protein NPRL2
NPR2-like protein
gene 21 protein
nitrogen permase homolog
nitrogen permease regulator 2-like protein
nitrogen permease regulator-like 2
tumor suppressor candidate 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018879.2NP_061367.1  GATOR1 complex protein NPRL2

    See identical proteins and their annotated locations for NP_061367.1

    Status: VALIDATED

    Source sequence(s)
    AI843290, AK010331, BY131176
    Consensus CDS
    CCDS23492.1
    UniProtKB/Swiss-Prot
    Q9WUE4
    Related
    ENSMUSP00000010201.4, ENSMUST00000010201.9
    Conserved Domains (1) summary
    cl24021
    Location:7370
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107419405..107422905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511768.3XP_006511831.1  GATOR1 complex protein NPRL2 isoform X1

    Conserved Domains (1) summary
    cl24021
    Location:7311
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3
  2. XM_036155141.1XP_036011034.1  GATOR1 complex protein NPRL2 isoform X2

    Conserved Domains (1) summary
    cl24021
    Location:7240
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3
  3. XM_006511769.5XP_006511832.1  GATOR1 complex protein NPRL2 isoform X3

    Conserved Domains (1) summary
    cl24021
    Location:7222
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3

RNA

  1. XR_379769.3 RNA Sequence

  2. XR_004935491.1 RNA Sequence

    Related
    ENSMUST00000193628.6
  3. XR_003947955.2 RNA Sequence