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man2a1 mannosidase, alpha, class 2A, member 1 [ Danio rerio (zebrafish) ]

Gene ID: 560219, updated on 9-Sep-2025
Official Symbol
man2a1provided by ZNC
Official Full Name
mannosidase, alpha, class 2A, member 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-060526-31
See related
Ensembl:ENSDARG00000102200 AllianceGenome:ZFIN:ZDB-GENE-060526-31
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-131c14.1
Summary
Predicted to enable alpha-mannosidase activity. Predicted to be involved in N-glycan processing. Predicted to act upstream of or within mannose metabolic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Orthologous to human MAN2A1 (mannosidase alpha class 2A member 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See man2a1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 5 NC_133180.1 (62329796..62464579, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 5 NC_007116.7 (57005846..57204497, complement)

Chromosome 5 - NC_133180.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141385624 Neighboring gene transmembrane protein 232 Neighboring gene uncharacterized LOC141385632 Neighboring gene praja ring finger ubiquitin ligase 2 Neighboring gene uncharacterized LOC141385631

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Arf6 and the 5'phosphatase of Synaptojanin 1 regulate autophagy in cone photoreceptors. George AA, et al. Inside Cell, 2016 Apr. PMID 27123470, Free PMC Article
  2. Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development. Insinna C, et al. Neural Dev, 2010 Apr 22. PMID 20412557, Free PMC Article
  3. Arf6 and the 5'phosphatase of synaptojanin 1 regulate autophagy in cone photoreceptors. George AA, et al. Bioessays, 2016 Jul. PMID 27417116
  4. The ciliopathy gene cc2d2a controls zebrafish photoreceptor outer segment development through a role in Rab8-dependent vesicle trafficking. Bachmann-Gagescu R, et al. Hum Mol Genet, 2011 Oct 15. PMID 21816947, Free PMC Article
  5. Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics. Paulus JD, et al. PLoS One, 2014. PMID 25329564, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
alpha-mannosidase 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110027.3 → NP_001103497.3  alpha-mannosidase 2

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000005
    Related
    ENSDARP00000139640.1, ENSDART00000171252.2

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133180.1 Reference GRCz12tu Primary Assembly

    Range
    62329796..62464579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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