hsp70l heat shock cognate 70-kd protein, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hsp70lprovided by ZNC
Official Full Name: heat shock cognate 70-kd protein, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050321-1
See related: Ensembl:ENSDARG00000055723 AllianceGenome:ZFIN:ZDB-GENE-050321-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: HSP70; hsp70-4
Summary: Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Acts upstream of or within several processes, including definitive hemopoiesis; response to cadmium ion; and response to heat. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in lens. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1A (heat shock protein family A (Hsp70) member 1A); and HSPA1B (heat shock protein family A (Hsp70) member 1B). [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

Location:: chromosome: 8

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	8	NC_133183.1 (6309856..6312609)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (4798158..4800911)

Chromosome 8 - NC_133183.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within definitive hemopoiesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to heat	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to metal ion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock cognate 70-kd protein, like

Names: stress protein HSP70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113589.1 → NP_001107061.1 heat shock cognate 70-kd protein, like

See identical proteins and their annotated locations for NP_001107061.1

Status: PROVISIONAL

Source sequence(s)

BC154432

UniProtKB/TrEMBL

A8WFS0

Related

ENSDARP00000030050.7, ENSDART00000031650.8

Conserved Domains (2) summary

cd10233
Location:8 → 383

HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins

PTZ00009
Location:5 → 643

PTZ00009; heat shock 70 kDa protein; Provisional