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NXF2 nuclear RNA export factor 2 [ Homo sapiens (human) ]

Gene ID: 56001, updated on 25-Nov-2021

Summary

Official Symbol
NXF2provided by HGNC
Official Full Name
nuclear RNA export factor 2provided by HGNC
Primary source
HGNC:HGNC:8072
See related
Ensembl:ENSG00000269405 MIM:300315
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT39; TAPL-2; TCP11X2
Summary
This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Aug 2013]
Expression
Restricted expression toward testis (RPKM 10.2) See more
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Genomic context

See NXF2 in Genome Data Viewer
Location:
Xq22.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (102247167..102326722)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101502161..101581636)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene t-complex 11 family, X-linked 3, pseudogene Neighboring gene t-complex 11 family, X-linked 1 Neighboring gene leucine rich repeat containing 14 pseudogene Neighboring gene nuclear RNA export factor 2B Neighboring gene t-complex 11 family, X-linked 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20416

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mRNA export from nucleus NAS
Non-traceable Author Statement
more info
PubMed 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of nuclear RNA export factor complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of nuclear RNA export factor complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
nuclear RNA export factor 2
Names
TAP-like protein 2
cancer/testis antigen 39
t-complex protein 11 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022053.4NP_071336.1  nuclear RNA export factor 2

    See identical proteins and their annotated locations for NP_071336.1

    Status: REVIEWED

    Source sequence(s)
    AC234791
    Consensus CDS
    CCDS14497.1
    UniProtKB/Swiss-Prot
    Q9GZY0
    Related
    ENSP00000485586.2, ENST00000625106.4
    Conserved Domains (5) summary
    smart00804
    Location:570623
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:229271
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam09162
    Location:121203
    Tap-RNA_bind; Tap, RNA-binding
    pfam13855
    Location:270332
    LRR_8; Leucine rich repeat
    cl09109
    Location:391543
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    102247167..102326722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039910.1: Suppressed sequence

    Description
    NM_001039910.1: This RefSeq was suppressed because it is thought to represent 5' UTR rather than a distinct protein coding region.
  2. NM_017809.3: Suppressed sequence

    Description
    NM_017809.3: This RefSeq was permanently suppressed because it is now thought that this transcript does encode a protein.
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