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MAPK11 mitogen-activated protein kinase 11 [ Homo sapiens (human) ]

Gene ID: 5600, updated on 1-Jun-2020

Summary

Official Symbol
MAPK11provided by HGNC
Official Full Name
mitogen-activated protein kinase 11provided by HGNC
Primary source
HGNC:HGNC:6873
See related
Ensembl:ENSG00000185386 MIM:602898
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P38B; SAPK2; p38-2; PRKM11; SAPK2B; p38Beta; P38BETA2
Summary
This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in fat (RPKM 13.9), brain (RPKM 10.1) and 22 other tissues See more
Orthologs

Genomic context

See MAPK11 in Genome Data Viewer
Location:
22q13.33
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (50263713..50270380, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50702142..50708779, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene histone deacetylase 10 Neighboring gene mitogen-activated protein kinase 12 Neighboring gene plexin B2 Neighboring gene DENN domain containing 6B Neighboring gene uncharacterized LOC105373096

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed
Nef nef HIV-1 Nef involves MAPK11 in the regulation of IL6 expression and activation of NF-kappaB PubMed
Tat tat The cysteine to serine mutation at position 31 in HIV-1 clade C Tat results in a marked decrease in IL-10 production in monocytes compared with clade B Tat. p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production PubMed
Vpr vpr HIV-1 Vpr-mediated upregulation of CXCL8 (IL8) involves p38-MAPK11 (beta isoform of p38-MAPK) in astrocytes PubMed
vpr Vpr-mediated upregulation of IL6 involves p38-MAPK11 (beta isoform of p38-MAPK) in astrocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase 11
Names
MAP kinase 11
MAP kinase p38 beta
mitogen-activated protein kinase p38 beta
mitogen-activated protein kinase p38-2
stress-activated protein kinase-2
stress-activated protein kinase-2b
NP_002742.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034042.1 RefSeqGene

    Range
    5001..11681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002751.7NP_002742.3  mitogen-activated protein kinase 11

    See identical proteins and their annotated locations for NP_002742.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AL022328
    Consensus CDS
    CCDS14090.1
    UniProtKB/Swiss-Prot
    Q15759
    Related
    ENSP00000333685.6, ENST00000330651.11
    Conserved Domains (1) summary
    cl21453
    Location:8348
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_110887.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL022328

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    50263713..50270380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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