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ACRV1 acrosomal vesicle protein 1 [ Homo sapiens (human) ]

Gene ID: 56, updated on 13-Mar-2020

Summary

Official Symbol
ACRV1provided by HGNC
Official Full Name
acrosomal vesicle protein 1provided by HGNC
Primary source
HGNC:HGNC:127
See related
Ensembl:ENSG00000134940 MIM:102525
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SP-10; SPACA2; D11S4365
Summary
This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
Expression
Restricted expression toward testis (RPKM 39.8) See more
Orthologs

Genomic context

See ACRV1 in Genome Data Viewer
Location:
11q24.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (125671522..125680847, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (125542229..125550809, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene STT3 oligosaccharyltransferase complex catalytic subunit A Neighboring gene checkpoint kinase 1 Neighboring gene RNA, U2 small nuclear 35, pseudogene Neighboring gene uncharacterized LOC105369551 Neighboring gene prostate and testis expressed 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acrosomal protein SP-10
Names
sperm protein 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047033.1 RefSeqGene

    Range
    5052..14377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001612.6NP_001603.1  acrosomal protein SP-10 isoform a precursor

    See identical proteins and their annotated locations for NP_001603.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the full length form of this gene, which encodes 265 aa. All other variants, as compared to this variant, lack one or two in-frame fragments in exons II and/or III.
    Source sequence(s)
    AP001132, BC014588
    Consensus CDS
    CCDS8460.1
    UniProtKB/Swiss-Prot
    P26436
    Related
    ENSP00000432816.1, ENST00000533904.6
    Conserved Domains (2) summary
    PHA03169
    Location:47184
    PHA03169; hypothetical protein; Provisional
    cd00117
    Location:188264
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  2. NM_020069.5NP_064454.1  acrosomal protein SP-10 isoform b precursor

    See identical proteins and their annotated locations for NP_064454.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a 57 nt fragment in the 3'-terminus of the exon II, as compared to variant 1. Isoform b encoded by this variant is thus 19 aa shorter than isoform a encoded by variant 1.
    Source sequence(s)
    AP001132, BC014588, DB446200, M82967
    Consensus CDS
    CCDS44759.1
    UniProtKB/Swiss-Prot
    P26436
    Related
    ENSP00000317684.3, ENST00000315608.7
    Conserved Domains (1) summary
    cd00117
    Location:169245
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  3. NM_020107.5NP_064492.1  acrosomal protein SP-10 isoform c precursor

    See identical proteins and their annotated locations for NP_064492.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a 165 nt fragment within exon II, which results in 55 aa fewer in isoform c, as compared to isoform a encoded by variant 1.
    Source sequence(s)
    AP001132, BC014588, BI826178, DB446200
    Consensus CDS
    CCDS8461.1
    UniProtKB/Swiss-Prot
    P26436
    Related
    ENSP00000433720.1, ENST00000530048.5
    Conserved Domains (1) summary
    cd00117
    Location:133209
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  4. NM_020108.5NP_064493.1  acrosomal protein SP-10 isoform d precursor

    See identical proteins and their annotated locations for NP_064493.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a 210 nt fragment in exon II, which results in 70 aa fewer in isoform d, as compared to isoform a encoded by variant 1.
    Source sequence(s)
    AP001132, BC014588, BG720361
    Consensus CDS
    CCDS44761.1
    UniProtKB/Swiss-Prot
    P26436
    Related
    ENSP00000436819.1, ENST00000527795.1
    Conserved Domains (1) summary
    cd00117
    Location:118194
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    125671522..125680847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020109.3: Suppressed sequence

    Description
    NM_020109.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_020110.3: Suppressed sequence

    Description
    NM_020110.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_020111.3: Suppressed sequence

    Description
    NM_020111.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  4. NM_020112.3: Suppressed sequence

    Description
    NM_020112.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  5. NM_020113.3: Suppressed sequence

    Description
    NM_020113.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  6. NM_020114.3: Suppressed sequence

    Description
    NM_020114.3: This RefSeq was permanently suppressed because it contains the wrong CDS.
  7. NM_020115.3: Suppressed sequence

    Description
    NM_020115.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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