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grin2bb glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b [ Danio rerio (zebrafish) ]

Gene ID: 559976, updated on 6-Jul-2026
Official Symbol
grin2bbprovided by ZNC
Official Full Name
glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061207-27
See related
Ensembl:ENSDARG00000030376 AllianceGenome:ZFIN:ZDB-GENE-061207-27
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-243a20.1
Summary
Predicted to enable NMDA glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential; glutamatergic synaptic transmission; and long-term synaptic potentiation. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of NMDA selective glutamate receptor complex. Predicted to be active in postsynaptic density membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy 27; neurodegenerative disease (multiple); and nicotine dependence. Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See grin2bb in Genome Data Viewer
Location:
chromosome: 1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 1 NC_133176.1 (48654963..48848529, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 1 NC_007112.7 (45372837..45566105, complement)

Chromosome 1 - NC_133176.1Genomic Context describing neighboring genes Neighboring gene si:ch211-243a20.3 Neighboring gene epithelial membrane protein 1a Neighboring gene uncharacterized LOC141386248 Neighboring gene coagulation factor VIII associated Neighboring gene NFAT activating protein with ITAM motif 1 Neighboring gene uncharacterized LOC137495816 Neighboring gene activating transcription factor 7 interacting protein Neighboring gene septin 3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Disruption of grin2A, an Epilepsy-Associated Gene, Produces Altered Spontaneous Swim Behavior in Zebrafish. Abramova V, et al. J Neurosci, 2025 Aug 13. PMID 40664506, Free PMC Article
  2. A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors. Hunt RF, et al. Exp Neurol, 2012 Sep. PMID 22735490, Free PMC Article
  3. 6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish. Gawel K, et al. Int J Mol Sci, 2021 Jul 20. PMID 34299361, Free PMC Article
  4. Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish. Zoodsma JD, et al. Mol Autism, 2022 Sep 22. PMID 36138431, Free PMC Article
  5. Molecular characterization and embryonic expression of the family of N-methyl-D-aspartate receptor subunit genes in the zebrafish. Cox JA, et al. Dev Dyn, 2005 Nov. PMID 16123982

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish.
    Title: Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NMDA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NMDA glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in excitatory postsynaptic potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in long-term synaptic potentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NMDA selective glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NMDA selective glutamate receptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b
Names
NR2B.2
grin2b

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128337.2 → NP_001121809.1  glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000001
    UniProtKB/TrEMBL
    A0A8M1NH89, A0AC58J6L6, A2BH14
    Related
    ENSDARP00000113415.2, ENSDART00000143664.3
    Conserved Domains (5) summary
    cd06378
    Location:107 → 470
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    cd13718
    Location:482 → 882
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:636 → 908
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:138 → 442
    ANF_receptor; Receptor family ligand binding region
    pfam10565
    Location:919 → 1770
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133176.1 Reference GRCz12tu Primary Assembly

    Range
    48654963..48848529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073946063.1 → XP_073802164.1  glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b isoform X3

    UniProtKB/TrEMBL
    A0A8M6Z5Y2, A0AC58J6R2

  2. XM_068219735.2 → XP_068075836.1  glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b isoform X1

    UniProtKB/TrEMBL
    A0A8M1NH89, A0AC58J6L6, A2BH14

  3. XM_068219733.1 → XP_068075834.1  glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b isoform X1

    UniProtKB/TrEMBL
    A0A8M1NH89, A0AC58J6L6, A2BH14

  4. XM_068219730.1 → XP_068075831.1  glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b isoform X1

    UniProtKB/TrEMBL
    A0A8M1NH89, A0AC58J6L6, A2BH14

  5. XM_017355013.3 → XP_017210502.1  glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b isoform X3

    UniProtKB/TrEMBL
    A0A8M6Z5Y2, A0AC58J6R2

  6. XM_017355012.3 → XP_017210501.1  glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b isoform X2

    UniProtKB/TrEMBL
    A0A8M6YZH9

  7. XM_073946022.1 → XP_073802123.1  glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b isoform X1

    UniProtKB/TrEMBL
    A0A8M1NH89, A0AC58J6L6, A2BH14

  8. XM_017355011.4 → XP_017210500.1  glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b isoform X1

    UniProtKB/TrEMBL
    A0A8M1NH89, A0AC58J6L6, A2BH14
    Conserved Domains (5) summary
    cd06378
    Location:107 → 470
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    cd13718
    Location:482 → 882
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:636 → 908
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:138 → 442
    ANF_receptor; Receptor family ligand binding region
    pfam10565
    Location:919 → 1770
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
Nucleotide Protein Strain
Heading Accession and Version

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