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cacna1fb calcium channel, voltage-dependent, L type, alpha 1F subunit [ Danio rerio (zebrafish) ]

Gene ID: 559964, updated on 9-Sep-2025
Official Symbol
cacna1fbprovided by ZNC
Official Full Name
calcium channel, voltage-dependent, L type, alpha 1F subunitprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031104-1
See related
Ensembl:ENSDARG00000023683 AllianceGenome:ZFIN:ZDB-GENE-031104-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cacna1f; ZfCav1.4
Summary
Predicted to enable high voltage-gated calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane. Predicted to act upstream of or within calcium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated calcium channel complex. Is expressed in atrium; cardiac ventricle; and retinal inner nuclear layer. Human ortholog(s) of this gene implicated in Aland Island eye disease; X-linked cone-rod dystrophy 3; congenital stationary night blindness; and congenital stationary night blindness 2A. Orthologous to human CACNA1F (calcium voltage-gated channel subunit alpha1 F). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See cacna1fb in Genome Data Viewer
Location:
chromosome: 8
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 8 NC_133183.1 (24743332..24819470)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 8 NC_007119.7 (22851472..22927224)

Chromosome 8 - NC_133183.1Genomic Context describing neighboring genes Neighboring gene IQ motif and Sec7 domain ArfGEF 2a Neighboring gene PDZ domain containing 4 Neighboring gene MAGI family member, X-linked a Neighboring gene uncharacterized LOC141375628 Neighboring gene synaptophysin a Neighboring gene proteolipid protein 2a

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. High-resolution optical imaging of zebrafish larval ribbon synapse protein RIBEYE, RIM2, and CaV 1.4 by stimulation emission depletion microscopy. Lv C, et al. Microsc Microanal, 2012 Aug. PMID 22832038, Free PMC Article
  2. Zebrafish Cacna1fa is required for cone photoreceptor function and synaptic ribbon formation. Jia S, et al. Hum Mol Genet, 2014 Jun 1. PMID 24419318, Free PMC Article
  3. Identification of calcium channel alpha1 subunit mRNA expressed in retinal bipolar neurons. Logiudice L, et al. Mol Vis, 2006 Mar 17. PMID 16568031, Free PMC Article
  4. Exposure of low-dose fipronil enantioselectively induced anxiety-like behavior associated with DNA methylation changes in embryonic and larval zebrafish. Qian Y, et al. Environ Pollut, 2019 Jun. PMID 30909129
  5. Expression of voltage-activated calcium channels in the early zebrafish embryo. Sanhueza D, et al. Zygote, 2009 May. PMID 19222870

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CACNA1F exhibited small spot-like staining beneath the RIM2 and RIBEYE structures.
    Title: High-resolution optical imaging of zebrafish larval ribbon synapse protein RIBEYE, RIM2, and CaV 1.4 by stimulation emission depletion microscopy.
  2. Cacna1fa is required for cone photoreceptor function and synaptic ribbon formation.
    Title: Zebrafish Cacna1fa is required for cone photoreceptor function and synaptic ribbon formation.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables high voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
calcium channel, voltage-dependent, L type, alpha 1F subunit
Names
calcium channel, voltage-dependent, alpha 1F subunit b

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324496.1 → NP_001311425.1  calcium channel, voltage-dependent, L type, alpha 1F subunit

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000008
    UniProtKB/TrEMBL
    A0A8M1P7S2, F1QH36
    Related
    ENSDARP00000041563.7, ENSDART00000041564.7
    Conserved Domains (4) summary
    pfam00520
    Location:141 → 407
    Ion_trans; Ion transport protein
    pfam08763
    Location:1504 → 1575
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1598 → 2062
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1439 → 1502
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133183.1 Reference GRCz12tu Primary Assembly

    Range
    24743332..24819470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478267.3 → XP_021333942.1  calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1

    UniProtKB/TrEMBL
    A0A8M9PQW6
    Conserved Domains (4) summary
    pfam00520
    Location:114 → 407
    Ion_trans; Ion transport protein
    pfam08763
    Location:1504 → 1575
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1601 → 2067
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1432 → 1502
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
Nucleotide Protein Strain
Heading Accession and Version

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