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Msh4 mutS homolog 4 [ Mus musculus (house mouse) ]

Gene ID: 55993, updated on 8-Feb-2024

Summary

Official Symbol
Msh4provided by MGI
Official Full Name
mutS homolog 4provided by MGI
Primary source
MGI:MGI:1860077
See related
Ensembl:ENSMUSG00000005493 AllianceGenome:MGI:1860077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mMsh4; 4930485C04Rik
Summary
Predicted to enable ATP-dependent activity, acting on DNA. Acts upstream of or within gamete generation; homologous chromosome pairing at meiosis; and ovarian follicle development. Located in recombination nodule and synaptonemal complex. Is expressed in several structures, including brain; gonad; heart; and thymus. Orthologous to human MSH4 (mutS homolog 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 2.5) and ovary adult (RPKM 0.1) See more
Orthologs
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Genomic context

See Msh4 in Genome Data Viewer
Location:
3 H3; 3 78.7 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (153562783..153611495, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (153857141..153906138, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25757 Neighboring gene ankyrin repeat and SOCS box-containing 17 Neighboring gene ankyrin repeat and SOCS box-containing 17, opposite strand Neighboring gene predicted gene, 24395 Neighboring gene Rab geranylgeranyl transferase, b subunit Neighboring gene small nucleolar RNA, C/D box 45B Neighboring gene predicted gene, 24494

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in recombination nodule IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptonemal complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptonemal complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
mutS protein homolog 4
Names
MutS homolog 4 variant iota 1
MutS homolog 4 variant theta 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282054.2NP_001268983.1  mutS protein homolog 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC087184
    Consensus CDS
    CCDS80067.1
    UniProtKB/TrEMBL
    A0A087WQG8, A0A087WQN0
    Related
    ENSMUSP00000140265.2, ENSMUST00000190449.2
    Conserved Domains (5) summary
    smart00533
    Location:162484
    MUTSd; DNA-binding domain of DNA mismatch repair MUTS family
    pfam00488
    Location:463699
    MutS_V; MutS domain V
    pfam05188
    Location:1121
    MutS_II; MutS domain II
    pfam05190
    Location:321415
    MutS_IV; MutS family domain IV
    pfam05192
    Location:143228
    MutS_III; MutS domain III
  2. NM_031870.4NP_114076.2  mutS protein homolog 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC087184
    Consensus CDS
    CCDS38678.1
    UniProtKB/Swiss-Prot
    Q920J1, Q99MT2
    UniProtKB/TrEMBL
    A6H6D5
    Related
    ENSMUSP00000005630.5, ENSMUST00000005630.11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    153562783..153611495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)