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MAPK8 mitogen-activated protein kinase 8 [ Homo sapiens (human) ]

Gene ID: 5599, updated on 5-Jul-2020

Summary

Official Symbol
MAPK8provided by HGNC
Official Full Name
mitogen-activated protein kinase 8provided by HGNC
Primary source
HGNC:HGNC:6881
See related
Ensembl:ENSG00000107643 MIM:601158
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in brain (RPKM 9.4), thyroid (RPKM 7.2) and 25 other tissues See more
Orthologs

Genomic context

See MAPK8 in Genome Data Viewer
Location:
10q11.22
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (48306639..48439360)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (49514682..49647403)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 2 Neighboring gene ribosomal protein S6 pseudogene 14 Neighboring gene Rho GTPase activating protein 22 Neighboring gene Sharpr-MPRA regulatory region 4601 Neighboring gene ARHGAP22 intronic transcript 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Env gp120 upregulates MAPK8 (JNK) in SVGA cells, human fetal astrocytes, and the prefrontal cortex of gp120 transgenic mice PubMed
env HIV-1 gp120-induced upregulation of APP protein production involves JNK MAPK signaling pathway in human cells PubMed
env Pretreatment of CD4+ T cells with HIV-1 gp120 followed by stimulation with jacalin results in marked inhibition of phosphorylation of ERK2 as well as JNK PubMed
env NF-kappaB and JNK signaling are involved in gp120-induced multidrug resistance protein 1 (Mrp1) regulation during an HIV-1 associated inflammatory response PubMed
env HIV-1 Env-pseudotyped virus-infected MDM cells induce cellular apoptosis through reactive oxygen species (ROS) generation and JNK phosphorylation PubMed
env CCR5 and CXCR4 coreceptor engagement by HIV-1 gp120 in primary macrophages activates 2 members of the mitogen-activated protein kinase (MAPK) superfamily, c-Jun amino-terminal kinase and p38 MAPK PubMed
env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
env HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells PubMed
env Increased neurotoxicity mediated by cocaine and gp120 involves signaling pathways including c-jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinases (MAPK), and nuclear factor (NF)-kappaB PubMed
env HIV-1 gp120 activates c-Jun N-terminal kinase (JNK) and p42 extracellular-regulated kinase (ERK) in primary human central nervous system (CNS) cells with an early peak of activation at 2 to 5 minutes PubMed
Envelope surface glycoprotein gp160, precursor env The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells PubMed
env Pre-incubation of CD4+ T lymphocytes with anti-CD4 mAb or HIV-1 gp160 inhibits the activation of c-Jun N-terminal kinases (JNK) and extracellular signal-regulated protein kinase 2 (ERK2) in response to phorbol 12-myristate 13-acetate and ionomycin PubMed
Nef nef HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1 PubMed
nef HIV-1 Nef inhibits ASK1-induced phosphorylation of p54/p46 JNK in cells. Nef mutant (152DEVGEANN/AAAAAAAA159) abolishes its inhibitory activity PubMed
nef HIV-1 Nef activates c-jun nuclear kinase (JNK) in human glial cells and the resulting activation promotes cell proliferation PubMed
nef The interaction between HIV-1 Nef and Vav leads to the activation of c-Jun N-terminal kinase (JNK) PubMed
nef Using genetic and immunohistochemical studies in Drosophila transgenic lines, wild-type HIV-1 Nef demonstrates induction of JNK activation and apoptotic activities PubMed
Tat tat HIV-1 Tat induces phosphorylation of MAPK8 (JNK) in CRT-MG human astroglioma cells PubMed
tat HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia and brain microvascular pericytes PubMed
tat Pretreatment of microglia with HIV-1 Tat followed by treatment with CX3CL1 results in inhibition of CX3CL1-mediated activation of ERK1/2 and JNK MAPKs compared to cells not treated with Tat PubMed
tat HIV-1 Tat-induced MAPK (ERK, JNK, and p38) activation is required for MMP-9 expression in human astrocytes PubMed
tat Treatment with HIV-1 Tat induces phosphorylation of ERK1/2 and JNK in brain micro vascular endothelial cells (BMEC) and astrocytes, which mediates Tat-induced multidrug resistance-associated protein 1 (MRP1) expression PubMed
tat Exposure of human umbilical vein endothelial cells to HIV-1 Tat causes broad activation of the unfolded-protein response in ER with phosphorylation of PERK, eIF2alpha, and JNK and induction of Grp78/BiP PubMed
tat HIV-1 Tat activates c-jun (Activator Protein-1; AP-1) through the activation of JNK, an effect mediated through the activation of p56lck PubMed
tat Extracellular HIV-1 Tat upregulates the expression of human beta-defensin 2 (hBD-2) via JNK/NF-KappaB/AP-1-dependent pathways in human B cells PubMed
tat Knocking down Nox2 by siRNA decreases HIV-1 Tat-induced NF-KappaB activation as well as activation of MAP kinases including ERK, JNK, and p38 PubMed
tat HIV-1 Tat and morphine-induced apoptosis in human neuroblastoma cells involves ERK1/2 and JNK activation PubMed
tat Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat PubMed
tat HIV-1-Tat-mediated upregulation of platelet-derived growth factor (PDGF) B chain in astrocytes is regulated by activation of ERK1/2 and JNK MAPK signaling pathways and the downstream transcription factor early growth response 1 (Egr1) PubMed
tat Sulfated polymannuroguluronate (SPMG) blocks the Tat-induced extracellular-signal regulated kinase 1/2- and c-jun amino-terminal kinase-mediated signalling pathways PubMed
tat HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha PubMed
tat Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT PubMed
tat Activation of JNK by HIV-1 Tat is mediated by TRAF4 PubMed
Vpr vpr HIV-1 Vpr-mediated regulation of IL6 involves MAPK8 (JnK-MAPK8) in astrocytes PubMed
vpr Vpr-mediated CXCL8 (IL8) secretion from astrocytes involves MAPK8 (Jnk-MAPK) PubMed
vpr Vpr-mediated CXCL8 (IL8) mRNA expression involves MAPK8 (Jnk-MAPK) in astrocytes PubMed
vpr Synthetic HIV-1 Vpr protein activates AP-1 (Jun/Fos), c-Jun N-terminal kinase (JNK), NF-kappaB, and MKK7 in both U937 cells and primary macrophages. PubMed
integrase gag-pol Cellular JNK1 phosphorylates HIV-1 IN on Ser57, leading to efficient HIV-1 infection and integration in primary human T lymphocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
JUN kinase activity TAS
Traceable Author Statement
more info
 
MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
JNK cascade TAS
Traceable Author Statement
more info
 
JUN phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to amino acid starvation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cadmium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to cytokine stimulus TAS
Traceable Author Statement
more info
 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
positive regulation of cyclase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of DNA replication origin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
regulation of macroautophagy TAS
Traceable Author Statement
more info
PubMed 
regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
response to UV IDA
Inferred from Direct Assay
more info
PubMed 
response to mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
basal dendrite ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase 8
Names
JUN N-terminal kinase
MAP kinase 8
c-Jun N-terminal kinase 1
mitogen-activated protein kinase 8 isoform JNK1 alpha1
mitogen-activated protein kinase 8 isoform JNK1 beta2
stress-activated protein kinase 1
stress-activated protein kinase 1c
NP_001265476.1
NP_001265477.1
NP_001310231.1
NP_001310249.1
NP_001310250.1
NP_001310251.1
NP_001310252.1
NP_001310253.1
NP_001310254.1
NP_001310255.1
NP_001310256.1
NP_001310257.1
NP_001310258.1
NP_001310259.1
NP_001310260.1
NP_620634.1
NP_620637.1
XP_024303847.1
XP_024303848.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029053.2 RefSeqGene

    Range
    5039..137722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278547.1NP_001265476.1  mitogen-activated protein kinase 8 isoform beta2

    See identical proteins and their annotated locations for NP_001265476.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (JNK1-b2) encodes the longer of the two JNK1 beta isoforms (JNK1 beta2). The JNK1-b2 variant differs from the JNK1-a2 variant in the use of an alternate internal coding exon of the same length. Thus, JNK1 beta2 isoform is the same length as JNK1 alpha2 isoform, with a few aa difference in an internal protein segment. Variants JNK1-b2, 8, 9, and 16 all encode isoform beta2.
    Source sequence(s)
    AA808177, AC016397, AK292523, DA159335
    Consensus CDS
    CCDS7223.1
    UniProtKB/Swiss-Prot
    P45983
    UniProtKB/TrEMBL
    A1L4K2
    Related
    ENSP00000378974.4, ENST00000395611.7
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  2. NM_001278548.1NP_001265477.1  mitogen-activated protein kinase 8 isoform 5

    See identical proteins and their annotated locations for NP_001265477.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame segment and uses a different acceptor splice site in the last coding exon compared to transcript variant JNK1-b2, resulting in a frameshift and a shorter isoform (5) with a different C-terminus compared to isoform JNK1 beta2.
    Source sequence(s)
    AA808177, AC016397, AK292523, DQ234352
    Consensus CDS
    CCDS60527.1
    UniProtKB/Swiss-Prot
    P45983
    UniProtKB/TrEMBL
    A1L4K2
    Related
    ENSP00000353483.4, ENST00000360332.7
    Conserved Domains (1) summary
    cl21453
    Location:25284
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001323302.2NP_001310231.1  mitogen-activated protein kinase 8 isoform alpha1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (JNK1-a1) uses a different acceptor splice site in the last coding exon compared to transcript variant JNK1-a2, resulting in a frameshift and a shorter isoform (JNK1 alpha1) with a different C-terminus, compared to isoform JNK1 alpha2. The JNK1-a1 variant differs from the JNK1-b1 variant in the use of an alternate internal coding exon of the same length. Thus, JNK1 alpha1 isoform is the same length as JNK1 beta1 isoform, with a few aa difference in an internal protein segment. Variants JNK1-a1, 10, 12, and 13 all encode isoform alpha1.
    Source sequence(s)
    AC016397, AC074325
    Consensus CDS
    CCDS7225.1
    UniProtKB/Swiss-Prot
    P45983
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  4. NM_001323320.2NP_001310249.1  mitogen-activated protein kinase 8 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC074325
  5. NM_001323321.2NP_001310250.1  mitogen-activated protein kinase 8 isoform beta1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), along with variants JNK1-b1 and 11, encodes isoform beta1.
    Source sequence(s)
    AC016397, AC074325
    Consensus CDS
    CCDS7226.1
    UniProtKB/Swiss-Prot
    P45983
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  6. NM_001323322.2NP_001310251.1  mitogen-activated protein kinase 8 isoform beta2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), along with variants JNK1-b2, 9, and 16, encodes isoform beta2.
    Source sequence(s)
    AC016397, AC074325
    Consensus CDS
    CCDS7223.1
    UniProtKB/Swiss-Prot
    P45983
    UniProtKB/TrEMBL
    A1L4K2
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  7. NM_001323323.2NP_001310252.1  mitogen-activated protein kinase 8 isoform beta2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), along with variants JNK1-b2, 8, and 16, encodes isoform beta2.
    Source sequence(s)
    AC016397, AC074325
    Consensus CDS
    CCDS7223.1
    UniProtKB/Swiss-Prot
    P45983
    UniProtKB/TrEMBL
    A1L4K2
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  8. NM_001323324.2NP_001310253.1  mitogen-activated protein kinase 8 isoform alpha1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), along with variants JNK1-a1, 12, and 13, encodes isoform alpha1.
    Source sequence(s)
    AC016397, AC074325
    Consensus CDS
    CCDS7225.1
    UniProtKB/Swiss-Prot
    P45983
    Related
    ENSP00000363297.3, ENST00000374182.7
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  9. NM_001323325.2NP_001310254.1  mitogen-activated protein kinase 8 isoform beta1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), along with variants JNK1-b1 and 7, encodes isoform beta1.
    Source sequence(s)
    AC016397, AC074325
    Consensus CDS
    CCDS7226.1
    UniProtKB/Swiss-Prot
    P45983
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  10. NM_001323326.2NP_001310255.1  mitogen-activated protein kinase 8 isoform alpha1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), along with variants JNK1-a1, 10, and 13, encodes isoform alpha1.
    Source sequence(s)
    AC016397, AC074325
    Consensus CDS
    CCDS7225.1
    UniProtKB/Swiss-Prot
    P45983
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  11. NM_001323327.2NP_001310256.1  mitogen-activated protein kinase 8 isoform alpha1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), along with variants JNK1-a1, 10, and 12, encodes isoform alpha1.
    Source sequence(s)
    AC016397, AC074325
    Consensus CDS
    CCDS7225.1
    UniProtKB/Swiss-Prot
    P45983
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  12. NM_001323328.2NP_001310257.1  mitogen-activated protein kinase 8 isoform alpha2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), along with variants JNK1-a2, 15, and 17, encodes isoform alpha2.
    Source sequence(s)
    AC016397, AC074325
    Consensus CDS
    CCDS7224.1
    UniProtKB/Swiss-Prot
    P45983
    Conserved Domains (2) summary
    smart00220
    Location:26321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  13. NM_001323329.2NP_001310258.1  mitogen-activated protein kinase 8 isoform alpha2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), along with variants JNK1-a2, 14, and 17, encodes isoform alpha2.
    Source sequence(s)
    AC016397, AC074325
    Consensus CDS
    CCDS7224.1
    UniProtKB/Swiss-Prot
    P45983
    Related
    ENSP00000363304.1, ENST00000374189.5
    Conserved Domains (2) summary
    smart00220
    Location:26321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  14. NM_001323330.2NP_001310259.1  mitogen-activated protein kinase 8 isoform beta2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), along with variants JNK1-b2, 8, and 9, encodes isoform beta2.
    Source sequence(s)
    AC016397, AC074325
    Consensus CDS
    CCDS7223.1
    UniProtKB/Swiss-Prot
    P45983
    UniProtKB/TrEMBL
    A1L4K2
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  15. NM_001323331.2NP_001310260.1  mitogen-activated protein kinase 8 isoform alpha2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), along with variants JNK1-a2, 14, and 15, encodes isoform alpha2.
    Source sequence(s)
    AC016397, AC074325
    Consensus CDS
    CCDS7224.1
    UniProtKB/Swiss-Prot
    P45983
    Conserved Domains (2) summary
    smart00220
    Location:26321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  16. NM_139046.4NP_620634.1  mitogen-activated protein kinase 8 isoform beta1

    See identical proteins and their annotated locations for NP_620634.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (JNK1-b1) uses a different acceptor splice site in the last coding exon compared to transcript variant JNK1-b2, resulting in a frameshift and a shorter isoform (JNK1 beta1) with a different C-terminus, compared to isoform JNK1 beta2. The JNK1-b1 variant differs from the JNK1-a1 variant in the use of an alternate internal coding exon of the same length. Thus, JNK1 beta1 isoform is the same length as JNK1 alpha1 isoform, with a few aa difference in an internal protein segment. Variants JNK1-b1, 7, and 11 all encode isoform beta1.
    Source sequence(s)
    AC016397, AC074325
    Consensus CDS
    CCDS7226.1
    UniProtKB/Swiss-Prot
    P45983
    Related
    ENSP00000363294.3, ENST00000374179.8
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  17. NM_139049.4NP_620637.1  mitogen-activated protein kinase 8 isoform alpha2

    See identical proteins and their annotated locations for NP_620637.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (JNK1-a2) encodes the longer of the two JNK1 alpha isoforms (JNK1 alpha2). The JNK1-a2 variant differs from the JNK1-b2 variant in the use of an alternate internal coding exon of the same length. Thus, JNK1 alpha2 isoform is the same length as JNK1 beta2 isoform, with a few aa difference in an internal protein segment. Variants JNK1-a2, 14, 15 and 17 all encode isoform alpha2.
    Source sequence(s)
    AC016397, AC074325
    Consensus CDS
    CCDS7224.1
    UniProtKB/Swiss-Prot
    P45983
    Conserved Domains (2) summary
    smart00220
    Location:26321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RNA

  1. NR_136583.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC074325
  2. NR_136584.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC074325
  3. NR_136585.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC074325

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    48306639..48439360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448079.1XP_024303847.1  mitogen-activated protein kinase 8 isoform X1

    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  2. XM_024448080.1XP_024303848.1  mitogen-activated protein kinase 8 isoform X2

    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_002750.3: Suppressed sequence

    Description
    NM_002750.3: This RefSeq was removed because the 5' UTR was partial.
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