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Nop58 NOP58 ribonucleoprotein [ Mus musculus (house mouse) ]

Gene ID: 55989, updated on 26-Sep-2022

Summary

Official Symbol
Nop58provided by MGI
Official Full Name
NOP58 ribonucleoproteinprovided by MGI
Primary source
MGI:MGI:1933184
See related
Ensembl:ENSMUSG00000026020 AllianceGenome:MGI:1933184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SIK; MSSP; Nol5; nop5
Summary
Predicted to enable ATPase binding activity; TFIID-class transcription factor complex binding activity; and snoRNA binding activity. Predicted to be involved in snoRNA localization. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in Cajal body; cytosol; and fibrillar center. Predicted to be part of box C/D RNP complex; pre-snoRNP complex; and small-subunit processome. Is expressed in brain; embryo; eye; heart; and pancreas epithelium. Orthologous to human NOP58 (NOP58 ribonucleoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 41.5), liver E14 (RPKM 35.5) and 20 other tissues See more
Orthologs
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Genomic context

See Nop58 in Genome Data Viewer
Location:
1; 1 C2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (59724134..59750669)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (59684961..59711510)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 973 Neighboring gene predicted gene, 33833 Neighboring gene small ubiquitin-like modifier 1 Neighboring gene small nucleolar RNA, C/D box 70 Neighboring gene predicted gene, 26293 Neighboring gene predicted gene, 26287 Neighboring gene small nucleolar RNA, C/D box 11 Neighboring gene bone morphogenetic protein receptor, type II (serine/threonine kinase) Neighboring gene family with sequence similarity 117, member B Neighboring gene arginyl-tRNA synthetase 2, mitochondrial pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC105209

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables TFIID-class transcription factor complex binding ISO
Inferred from Sequence Orthology
more info
 
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables snoRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in snoRNA localization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
 
part_of box C/D RNP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of box C/D RNP complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of pre-snoRNP complex ISO
Inferred from Sequence Orthology
more info
 
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of sno(s)RNA-containing ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nucleolar protein 58
Names
NOP58 ribonucleoprotein homolog
SIK similar protein
nucleolar protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018868.2NP_061356.2  nucleolar protein 58

    See identical proteins and their annotated locations for NP_061356.2

    Status: VALIDATED

    Source sequence(s)
    AK034577, AK044216, AK134286
    Consensus CDS
    CCDS35587.1
    UniProtKB/Swiss-Prot
    Q6DFW4, Q8C8Y7
    Related
    ENSMUSP00000140250.2, ENSMUST00000191142.7
    Conserved Domains (3) summary
    smart00931
    Location:162213
    NOSIC; NOSIC (NUC001) domain
    pfam01798
    Location:168396
    Nop; snoRNA binding domain, fibrillarin
    pfam08156
    Location:266
    NOP5NT; NOP5NT (NUC127) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    59724134..59750669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496149.4XP_006496212.1  nucleolar protein 58 isoform X1

    See identical proteins and their annotated locations for XP_006496212.1

    Conserved Domains (1) summary
    pfam01798
    Location:106333
    Nop; snoRNA binding domain, fibrillarin
  2. XM_036152470.1XP_036008363.1  nucleolar protein 58 isoform X1

    Conserved Domains (1) summary
    pfam01798
    Location:106333
    Nop; snoRNA binding domain, fibrillarin