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Cpxm2 carboxypeptidase X, M14 family member 2 [ Mus musculus (house mouse) ]

Gene ID: 55987, updated on 7-May-2024

Summary

Official Symbol
Cpxm2provided by MGI
Official Full Name
carboxypeptidase X, M14 family member 2provided by MGI
Primary source
MGI:MGI:1926006
See related
Ensembl:ENSMUSG00000030862 AllianceGenome:MGI:1926006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cpx2; CPX-2; 4632435C11Rik
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be located in extracellular region. Is expressed in blood vessel; nasal cavity epithelium; and skin. Orthologous to human CPXM2 (carboxypeptidase X, M14 family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 11.7), genital fat pad adult (RPKM 8.2) and 16 other tissues See more
Orthologs
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Genomic context

See Cpxm2 in Genome Data Viewer
Location:
7 F3; 7 75.6 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (131634416..131756483, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (132032687..132154765, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34725 Neighboring gene G protein-coupled receptor 26 Neighboring gene STARR-seq mESC enhancer starr_20288 Neighboring gene STARR-seq mESC enhancer starr_20291 Neighboring gene carbohydrate sulfotransferase 15 Neighboring gene STARR-positive B cell enhancer ABC_E8215 Neighboring gene predicted gene 10584 Neighboring gene predicted gene, 34908

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables carboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NOT acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
NOT located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inactive carboxypeptidase-like protein X2
Names
carboxypeptidase X 2 (M14 family)
carboxypeptidase X2
metallocarboxypeptidase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018867.5NP_061355.3  inactive carboxypeptidase-like protein X2 precursor

    See identical proteins and their annotated locations for NP_061355.3

    Status: VALIDATED

    Source sequence(s)
    AC100735, AK019509, BB027417
    Consensus CDS
    CCDS21921.1
    UniProtKB/Swiss-Prot
    O54860, Q8VDQ4, Q9D2L5
    UniProtKB/TrEMBL
    A0A0R4J0C4
    Related
    ENSMUSP00000033149.5, ENSMUST00000033149.5
    Conserved Domains (4) summary
    cd03869
    Location:322647
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:651726
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:146301
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:145300
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    131634416..131756483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508034.5XP_006508097.1  inactive carboxypeptidase-like protein X2 isoform X2

    UniProtKB/Swiss-Prot
    O54860, Q8VDQ4, Q9D2L5
    Conserved Domains (3) summary
    cd00057
    Location:145300
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd03869
    Location:326647
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cl21470
    Location:651681
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
  2. XM_006508033.5XP_006508096.1  inactive carboxypeptidase-like protein X2 isoform X1

    UniProtKB/Swiss-Prot
    O54860, Q8VDQ4, Q9D2L5
    Conserved Domains (3) summary
    cd11308
    Location:591666
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd00057
    Location:145300
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl11393
    Location:326587
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  3. XM_011241864.1XP_011240166.1  inactive carboxypeptidase-like protein X2 isoform X3

    Conserved Domains (3) summary
    cd11308
    Location:445520
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd00057
    Location:1394
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd03869
    Location:120441
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
  4. XM_030242804.1XP_030098664.1  inactive carboxypeptidase-like protein X2 isoform X5

    Conserved Domains (3) summary
    cd11308
    Location:356431
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd00057
    Location:165
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl11393
    Location:91352
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  5. XM_006508036.3XP_006508099.1  inactive carboxypeptidase-like protein X2 isoform X4

    Conserved Domains (3) summary
    cd11308
    Location:416491
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd00057
    Location:165
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd03869
    Location:91412
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup