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MAPK6 mitogen-activated protein kinase 6 [ Homo sapiens (human) ]

Gene ID: 5597, updated on 5-Mar-2024

Summary

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Official Symbol
MAPK6provided by HGNC
Official Full Name
mitogen-activated protein kinase 6provided by HGNC
Primary source
HGNC:HGNC:6879
See related
Ensembl:ENSG00000069956 MIM:602904; AllianceGenome:HGNC:6879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERK3; PRKM6; p97MAPK; HsT17250
Summary
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 25.2), brain (RPKM 20.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
15q21.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (51971825..52067375)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (49779463..49875996)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (52311416..52359572)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268148 Neighboring gene LEO1 homolog, Paf1/RNA polymerase II complex component pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9409 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:52239187-52239400 Neighboring gene LEO1 homolog, Paf1/RNA polymerase II complex component Neighboring gene H3K27ac hESC enhancers GRCh37_chr15:52263092-52263668 and GRCh37_chr15:52263669-52264244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9412 Neighboring gene Sharpr-MPRA regulatory region 2333 Neighboring gene Sharpr-MPRA regulatory region 7002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9415 Neighboring gene MAPK6 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:52317121-52317701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9416 Neighboring gene MPRA-validated peak2339 silencer Neighboring gene uncharacterized LOC112268150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9417 Neighboring gene uncharacterized LOC124903494 Neighboring gene MAPK6-RPS13P8 intergenic CAGE-defined mid-level expression enhancer Neighboring gene ReSE screen-validated silencer GRCh37_chr15:52386957-52387157 Neighboring gene ribosomal protein S13 pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CircRNA_100395 protects breast carcinoma deterioration by targeting MAPK6. Yu XP, et al. Eur Rev Med Pharmacol Sci, 2020 Dec. PMID 33336740
  2. Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3. Schröder M, et al. Int J Mol Sci, 2020 Oct 26. PMID 33114754, Free PMC Article
  3. ERK3/MAPK6 is required for KRAS-mediated NSCLC tumorigenesis. Bogucka K, et al. Cancer Gene Ther, 2021 May. PMID 33070159
  4. Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity. De la Mota-Peynado A, et al. J Biol Chem, 2011 Apr 15. PMID 21317288, Free PMC Article
  5. Molecular cloning, isolation and characterisation of ERK3 gene from chewing-tobacco induced oral squamous cell carcinoma. Rai R, et al. Oral Oncol, 2004 Aug. PMID 15172640

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased methylation of ZNF671 suppresses tumor progression by promoting MAPK6 transcription in laryngeal carcinoma.
    Title: Increased methylation of ZNF671 suppresses tumor progression by promoting MAPK6 transcription in laryngeal carcinoma.
  2. ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization.
    Title: ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization.
  3. miR-128-3p inhibits the inflammation by targeting MAPK6 in penicillin-induced astrocytes.
    Title: miR-128-3p inhibits the inflammation by targeting MAPK6 in penicillin-induced astrocytes.
  4. LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway.
    Title: LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway.
  5. ERK3/MAPK6 is required for KRAS-mediated NSCLC tumorigenesis.
    Title: ERK3/MAPK6 is required for KRAS-mediated NSCLC tumorigenesis.
  6. CircRNA_100395 protects breast carcinoma deterioration by targeting MAPK6.
    Title: CircRNA_100395 protects breast carcinoma deterioration by targeting MAPK6.
  7. ERK3 is transcriptionally upregulated by Np63alpha and mediates the role of Np63alpha in suppressing cell migration in non-melanoma skin cancers.
    Title: ERK3 is transcriptionally upregulated by ∆Np63α and mediates the role of ∆Np63α in suppressing cell migration in non-melanoma skin cancers.
  8. miR6535p suppresses the growth and migration of breast cancer cells by targeting MAPK6.
    Title: miR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6.
  9. let7f5p attenuates inflammatory injury in in vitro pneumonia models by targeting MAPK6.
    Title: let7f‑5p attenuates inflammatory injury in in vitro pneumonia models by targeting MAPK6.
  10. ERK3/MAPK6 controls IL-8 production and chemotaxis.
    Title: ERK3/MAPK6 controls IL-8 production and chemotaxis.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686F03189

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of dendritic spine development IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
located_in septin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 6
Names
ERK-3
MAP kinase 6
MAPK 6
extracellular signal-regulated kinase 3
extracellular signal-regulated kinase, p97
p97-MAPK
protein kinase, mitogen-activated 5
protein kinase, mitogen-activated 6
NP_002739.1
XP_005254594.1
XP_005254595.1
XP_011520084.1
XP_047288803.1
XP_047288804.1
XP_047288805.1
XP_047288806.1
XP_047288807.1
XP_047288808.1
XP_047288809.1
XP_047288810.1
XP_047288811.1
XP_054234407.1
XP_054234408.1
XP_054234409.1
XP_054234410.1
XP_054234411.1
XP_054234412.1
XP_054234413.1
XP_054234414.1
XP_054234415.1
XP_054234416.1
XP_054234417.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002748.4 → NP_002739.1  mitogen-activated protein kinase 6

    See identical proteins and their annotated locations for NP_002739.1

    Status: REVIEWED

    Source sequence(s)
    AC023906, BC035492, DA109756, L77964
    Consensus CDS
    CCDS10147.1
    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8
    Related
    ENSP00000261845.5, ENST00000261845.7
    Conserved Domains (1) summary
    cd07854
    Location:14 → 355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    51971825..52067375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432852.1 → XP_047288808.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8
    Related
    ENSP00000509662.1, ENST00000691380.1

  2. XM_047432853.1 → XP_047288809.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  3. XM_005254537.4 → XP_005254594.1  mitogen-activated protein kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_005254594.1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8
    Conserved Domains (1) summary
    cd07854
    Location:14 → 355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  4. XM_005254538.3 → XP_005254595.1  mitogen-activated protein kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_005254595.1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8
    Related
    ENSP00000506036.1, ENST00000681888.1
    Conserved Domains (1) summary
    cd07854
    Location:14 → 355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  5. XM_011521782.2 → XP_011520084.1  mitogen-activated protein kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_011520084.1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8
    Conserved Domains (1) summary
    cd07854
    Location:14 → 355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  6. XM_047432855.1 → XP_047288811.1  mitogen-activated protein kinase 6 isoform X2

  7. XM_047432851.1 → XP_047288807.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  8. XM_047432847.1 → XP_047288803.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  9. XM_047432850.1 → XP_047288806.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  10. XM_047432849.1 → XP_047288805.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  11. XM_047432854.1 → XP_047288810.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  12. XM_047432848.1 → XP_047288804.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    49779463..49875996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378439.1 → XP_054234414.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  2. XM_054378440.1 → XP_054234415.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  3. XM_054378434.1 → XP_054234409.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  4. XM_054378432.1 → XP_054234407.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  5. XM_054378433.1 → XP_054234408.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  6. XM_054378437.1 → XP_054234412.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  7. XM_054378436.1 → XP_054234411.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  8. XM_054378435.1 → XP_054234410.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  9. XM_054378438.1 → XP_054234413.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  10. XM_054378442.1 → XP_054234417.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8

  11. XM_054378441.1 → XP_054234416.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/Swiss-Prot
    B2R945, B5BU65, Q16659, Q68DH4, Q8IYN8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16659.1 GenPept UniProtKB/Swiss-Prot:Q16659

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