Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Agpat1provided by MGI
Official Full Name: 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)provided by MGI
Primary source: MGI:MGI:1932075
See related: Ensembl:ENSMUSG00000034254 AllianceGenome:MGI:1932075
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1-AGP; 1-AGPAT
Summary: Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Acts upstream of or within phosphatidic acid biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum adult (RPKM 284.0), testis adult (RPKM 273.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.18 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34823169..34832423)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34604195..34613449)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Agpat1-/- mice developed widespread disturbances of metabolism, sperm development, and neurologic function resulting from disrupted phospholipid homeostasis. AGPAT1 appears to serve important functions in the physiology of multiple organ systems. The Agpat1-deficient mouse provides an important model in which to study the contribution of phospholipid and triacylglycerol synthesis to physiology and diseases.
Title: Metabolic, Reproductive, and Neurologic Abnormalities in Agpat1-Null Mice.
observations strongly implicate AGPAT1 in the development of skeletal muscle, specifically to terminal differentiation. These findings are linked to the regulation of actin cytoskeleton
Title: A role for 1-acylglycerol-3-phosphate-O-acyltransferase-1 in myoblast differentiation.
mtGPAT1 might serve as a novel target for treatment of hepatic steatosis and hepatic insulin resistance and that long chain acyl-CoA's do not mediate fat-induced hepatic insulin resistance in this model.
Title: Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice.
mAGPAT 1, 2, and 3 mRNA levels increased rapidly in mouse skin after acute permeability barrier disruption
Title: Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237629

Agpat1 (e-PCR), detects polymorphism
- UniSTS:546637

AW047140 (e-PCR)
- UniSTS:166054

Homology

Orthologs from Annotation Pipeline: 271 organisms have orthologs with human gene Agpat1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within phosphatidic acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

Names: 1-AGP acyltransferase 1; 1-AGPAT 1; Lpaat-alpha; lysophosphatidic acid acyltransferase alpha

NP_001156851.1

EC 2.3.1.51

NP_061350.3

EC 2.3.1.51

XP_006524710.1

EC 2.3.1.51

XP_006524711.1

EC 2.3.1.51

XP_030105775.1

EC 2.3.1.51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163379.2 → NP_001156851.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

CT009767

Consensus CDS

CCDS37590.1

UniProtKB/Swiss-Prot

O35083

UniProtKB/TrEMBL

A0A0R4J263

Related

ENSMUSP00000048573.9, ENSMUST00000037489.15

Conserved Domains (1) summary

cd07989
Location:66 → 253

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
NM_001414236.1 → NP_001401165.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

Status: VALIDATED

Source sequence(s)

CT009767

UniProtKB/TrEMBL

A0A0R4J263
NM_001414237.1 → NP_001401166.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

Status: VALIDATED

Source sequence(s)

CT009767

UniProtKB/TrEMBL

A0A0R4J263
NM_001414238.1 → NP_001401167.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

Status: VALIDATED

Source sequence(s)

CT009767

UniProtKB/TrEMBL

A0A0R4J263
NM_001414239.1 → NP_001401168.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 2 precursor

Status: VALIDATED

Source sequence(s)

CT009767
NM_001414240.1 → NP_001401169.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 3 precursor

Status: VALIDATED

Source sequence(s)

CT009767
NM_001414241.1 → NP_001401170.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 4

Status: VALIDATED

Source sequence(s)

CT009767
NM_001414242.1 → NP_001401171.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 4

Status: VALIDATED

Source sequence(s)

CT009767
NM_018862.4 → NP_061350.3 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

CT009767

Consensus CDS

CCDS37590.1

UniProtKB/Swiss-Prot

O35083

UniProtKB/TrEMBL

A0A0R4J263

Related

ENSMUSP00000109776.4, ENSMUST00000114140.10

Conserved Domains (1) summary

cd07989
Location:66 → 253

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

34823169..34832423

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524647.3 → XP_006524710.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1

UniProtKB/Swiss-Prot

O35083

UniProtKB/TrEMBL

A0A0R4J263

Conserved Domains (1) summary

cd07989
Location:66 → 253

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
XM_006524648.2 → XP_006524711.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1

UniProtKB/Swiss-Prot

O35083

UniProtKB/TrEMBL

A0A0R4J263

Conserved Domains (1) summary

cd07989
Location:66 → 253

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
XM_030249915.1 → XP_030105775.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1

Conserved Domains (1) summary

cd07989
Location:66 → 253

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like