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RAB5IF RAB5 interacting factor [ Homo sapiens (human) ]

Gene ID: 55969, updated on 5-Jan-2020

Summary

Official Symbol
RAB5IFprovided by HGNC
Official Full Name
RAB5 interacting factorprovided by HGNC
Primary source
HGNC:HGNC:15870
See related
Ensembl:ENSG00000101084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIP5; RCAF1; PNAS-11; C20orf24
Expression
Ubiquitous expression in bone marrow (RPKM 56.7), esophagus (RPKM 45.4) and 25 other tissues See more
Orthologs

Genomic context

See RAB5IF in Genome Data Viewer
Location:
20q11.23
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (36605779..36612557)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (35234137..35240960)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene TGIF2-RAB5IF readthrough Neighboring gene TGFB induced factor homeobox 2 Neighboring gene uncharacterized LOC107985397 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 2 Neighboring gene Src like adaptor 2 Neighboring gene NDRG family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with chromosome 20 open reading frame 24 (C20orf24) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough TGIF2-RAB5IF

Readthrough gene: TGIF2-RAB5IF, Included gene: TGIF2

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
uncharacterized protein RAB5IF
Names
rab5-interacting protein
respirasome complex assembly factor 1
uncharacterized protein C20orf24

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199534.2NP_001186463.1  uncharacterized protein RAB5IF isoform c

    See identical proteins and their annotated locations for NP_001186463.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. The resulting isoform (c) is longer and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AF112213, BC001871, BG395753, BI223439
    Consensus CDS
    CCDS56190.1
    UniProtKB/Swiss-Prot
    Q9BUV8
    Related
    ENSP00000362958.5, ENST00000373852.9
    Conserved Domains (1) summary
    pfam07019
    Location:44118
    Rab5ip; Rab5-interacting protein (Rab5ip)
  2. NM_001374178.1NP_001361107.1  uncharacterized protein RAB5IF isoform d

    Status: VALIDATED

    Source sequence(s)
    AL050318
  3. NM_018840.5NP_061328.1  uncharacterized protein RAB5IF isoform a

    See identical proteins and their annotated locations for NP_061328.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shortest isoform (a).
    Source sequence(s)
    AF112213, BG395753, BI223439
    Consensus CDS
    CCDS13280.1
    UniProtKB/Swiss-Prot
    Q9BUV8
    Related
    ENSP00000340164.3, ENST00000344795.8
    Conserved Domains (1) summary
    pfam07019
    Location:44120
    Rab5ip; Rab5-interacting protein (Rab5ip)
  4. NM_199483.3NP_955777.1  uncharacterized protein RAB5IF isoform b

    See identical proteins and their annotated locations for NP_955777.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon that causes a frameshift in the 3' coding region, compared to variant 1. The resulting isoform (b) is longer and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AF112213, BG395753, BI223439, BU189639
    Consensus CDS
    CCDS13279.1
    UniProtKB/Swiss-Prot
    Q9BUV8
    Related
    ENSP00000341213.3, ENST00000342422.3
    Conserved Domains (1) summary
    pfam07019
    Location:4479
    Rab5ip; Rab5-interacting protein (Rab5ip)

RNA

  1. NR_026562.4 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF112213, AL050318, BG395753, BI223439
    Related
    ENST00000483815.5
  2. NR_164350.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL050318
  3. NR_164351.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL050318

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    36605779..36612557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199484.1: Suppressed sequence

    Description
    NM_199484.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_199485.1: Suppressed sequence

    Description
    NM_199485.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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