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AJAP1 adherens junctions associated protein 1 [ Homo sapiens (human) ]

Gene ID: 55966, updated on 1-Jun-2020

Summary

Official Symbol
AJAP1provided by HGNC
Official Full Name
adherens junctions associated protein 1provided by HGNC
Primary source
HGNC:HGNC:30801
See related
Ensembl:ENSG00000196581 MIM:610972
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOT8; SHREW1; SHREW-1
Expression
Biased expression in brain (RPKM 4.3), ovary (RPKM 2.3) and 5 other tissues See more
Orthologs

Genomic context

See AJAP1 in Genome Data Viewer
Location:
1p36.32
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (4654609..4792534)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (4715105..4843851)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1646 Neighboring gene uncharacterized LOC107985376 Neighboring gene long intergenic non-protein coding RNA 2781 Neighboring gene uncharacterized LOC102724429

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
NHGRI GWA Catalog
GWAS of dental caries patterns in the permanent dentition.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of wound healing IDA
Inferred from Direct Assay
more info
PubMed 
regulation of polarized epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell contact zone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell contact zone IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
spanning component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spanning component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adherens junction-associated protein 1
Names
membrane protein shrew-1
transmembrane protein SHREW1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042478.2NP_001035943.1  adherens junction-associated protein 1 precursor

    See identical proteins and their annotated locations for NP_001035943.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF175409, AL023586, AL049673, AL391808, AY282806
    Consensus CDS
    CCDS54.1
    UniProtKB/Swiss-Prot
    Q9UKB5
    Related
    ENSP00000367432.3, ENST00000378190.7
    Conserved Domains (1) summary
    pfam15298
    Location:181388
    AJAP1_PANP_C; AJAP1/PANP C-terminus
  2. NM_018836.4NP_061324.1  adherens junction-associated protein 1 precursor

    See identical proteins and their annotated locations for NP_061324.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF175409, AL023586, AL391808, AY282806
    Consensus CDS
    CCDS54.1
    UniProtKB/Swiss-Prot
    Q9UKB5
    Related
    ENSP00000367433.3, ENST00000378191.5
    Conserved Domains (1) summary
    pfam15298
    Location:181388
    AJAP1_PANP_C; AJAP1/PANP C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    4654609..4792534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541786.2XP_011540088.1  adherens junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011540088.1

    UniProtKB/Swiss-Prot
    Q9UKB5
    Conserved Domains (1) summary
    pfam15298
    Location:181388
    AJAP1_PANP_C; AJAP1/PANP C-terminus
  2. XM_011541787.2XP_011540089.1  adherens junction-associated protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011540089.1

    Conserved Domains (1) summary
    pfam15298
    Location:170377
    AJAP1_PANP_C; AJAP1/PANP C-terminus
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