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MAPK4 mitogen-activated protein kinase 4 [ Homo sapiens (human) ]

Gene ID: 5596, updated on 26-Sep-2021

Summary

Official Symbol
MAPK4provided by HGNC
Official Full Name
mitogen-activated protein kinase 4provided by HGNC
Primary source
HGNC:HGNC:6878
See related
Ensembl:ENSG00000141639 MIM:176949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERK4; ERK-4; PRKM4; p63MAPK; p63-MAPK
Summary
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Biased expression in adrenal (RPKM 3.2), brain (RPKM 3.1) and 11 other tissues See more
Orthologs
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Genomic context

See MAPK4 in Genome Data Viewer
Location:
18q21.1-q21.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (50559772..50731826)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (48086457..48258196)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr18.1136 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 11 Neighboring gene uncharacterized LOC105372116 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 16 Neighboring gene maestro

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase 4
Names
Erk3-related
MAPK 4
extracellular signal-regulated kinase 4
NP_001278968.1
NP_001278969.1
NP_002738.2
XP_005258356.1
XP_011524376.1
XP_011524377.1
XP_011524378.1
XP_011524379.1
XP_011524380.1
XP_016881328.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001292039.2NP_001278968.1  mitogen-activated protein kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_001278968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks part of the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA771957, AC090638, AK293818, AK295058, BC040493, BC050299
    Consensus CDS
    CCDS77189.1
    UniProtKB/Swiss-Prot
    P31152
    UniProtKB/TrEMBL
    B4DEW2
    Related
    ENSP00000439231.1, ENST00000540640.3
    Conserved Domains (1) summary
    cl21453
    Location:1140
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001292040.2NP_001278969.1  mitogen-activated protein kinase 4 isoform 3

    See identical proteins and their annotated locations for NP_001278969.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two exons in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA771957, AC090638, BC040493, BC050299, X59727
    Consensus CDS
    CCDS77188.1
    UniProtKB/Swiss-Prot
    P31152
    UniProtKB/TrEMBL
    K7ELV1
    Related
    ENSP00000466233.1, ENST00000592595.5
    Conserved Domains (1) summary
    cl21453
    Location:14231
    PKc_like; Protein Kinases, catalytic domain
  3. NM_002747.4NP_002738.2  mitogen-activated protein kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_002738.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC090638, AI088913, BC040493, BC050299, X59727
    Consensus CDS
    CCDS42437.1
    UniProtKB/Swiss-Prot
    P31152
    Related
    ENSP00000383234.1, ENST00000400384.7
    Conserved Domains (1) summary
    cd07854
    Location:14351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    50559772..50731826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025839.2XP_016881328.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/Swiss-Prot
    P31152
    Conserved Domains (1) summary
    cd07854
    Location:14351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
  2. XM_011526076.2XP_011524378.1  mitogen-activated protein kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_011524378.1

    UniProtKB/Swiss-Prot
    P31152
    Conserved Domains (1) summary
    cd07854
    Location:14351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
  3. XM_011526074.2XP_011524376.1  mitogen-activated protein kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_011524376.1

    UniProtKB/Swiss-Prot
    P31152
    Conserved Domains (1) summary
    cd07854
    Location:14351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
  4. XM_005258299.3XP_005258356.1  mitogen-activated protein kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_005258356.1

    UniProtKB/Swiss-Prot
    P31152
    Conserved Domains (1) summary
    cd07854
    Location:14351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
  5. XM_011526075.3XP_011524377.1  mitogen-activated protein kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_011524377.1

    UniProtKB/Swiss-Prot
    P31152
    Conserved Domains (1) summary
    cd07854
    Location:14351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
  6. XM_011526077.2XP_011524379.1  mitogen-activated protein kinase 4 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:8176
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011526078.2XP_011524380.1  mitogen-activated protein kinase 4 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:29100
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001753242.2 RNA Sequence

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