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SULF2 sulfatase 2 [ Homo sapiens (human) ]

Gene ID: 55959, updated on 1-Jun-2020

Summary

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Official Symbol
SULF2provided by HGNC
Official Full Name
sulfatase 2provided by HGNC
Primary source
HGNC:HGNC:20392
See related
Ensembl:ENSG00000196562 MIM:610013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSULF-2
Summary
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in ovary (RPKM 36.9), endometrium (RPKM 36.6) and 24 other tissues See more
Orthologs
mouse all

Genomic context

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See SULF2 in Genome Data Viewer
Location:
20q13.12
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (47654569..47786616, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (46286150..46415360, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 3 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene nuclear receptor coactivator 3 repeat instability region Neighboring gene uncharacterized LOC107985401 Neighboring gene RNA, U7 small nuclear 173 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Recapitulation of pharmacogenomic data reveals that invalidation of SULF2 enhance sorafenib susceptibility in liver cancer. Yoon S, et al. Oncogene, 2018 Aug. PMID 29720727
  2. Sulfatase-2 promotes the growth and metastasis of colorectal cancer by activating Akt and Erk1/2 pathways. Tao Y, et al. Biomed Pharmacother, 2017 May. PMID 28320104
  3. Evaluating Tumor-Associated Activity of Extracellular Sulfatase by Analyzing Naturally Occurring Substrate in Tumor Microenvironment of Hepatocellular Carcinoma. Yu Y, et al. Anal Chem, 2016 Dec 20. PMID 28193024
  4. Impact of Sulfatase-2 on cancer progression and prognosis in patients with renal cell carcinoma. Kumagai S, et al. Cancer Sci, 2016 Nov. PMID 27589337, Free PMC Article
  5. Sulfatase-2: a prognostic biomarker and candidate therapeutic target in patients with pancreatic ductal adenocarcinoma. Alhasan SF, et al. Br J Cancer, 2016 Sep 27. PMID 27560551, Free PMC Article

See all (69) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment
    Title: TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment.
  2. Loss of SULF2 expression is associated with corticospinal tract defect.
    Title: Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.
  3. SULF2 plays a key role in sorafenib susceptibility.
    Title: Recapitulation of pharmacogenomic data reveals that invalidation of SULF2 enhance sorafenib susceptibility in liver cancer.
  4. High SULF2 expression is associated with glioma.
    Title: Multi-tasking Sulf1/Sulf2 enzymes do not only facilitate extracellular cell signalling but also participate in cell cycle related nuclear events.
  5. The activity of sulfatase 2, a major form of endosulfatase in hepatocellular carcinoma can be studied, in connection with the interactions between heparan sulfate and various growth factors.
    Title: Evaluating Tumor-Associated Activity of Extracellular Sulfatase by Analyzing Naturally Occurring Substrate in Tumor Microenvironment of Hepatocellular Carcinoma.
  6. SULF2 promotes the growth and metastasis of CRC probably by activating Akt and Erk1/2 pathways.
    Title: Sulfatase-2 promotes the growth and metastasis of colorectal cancer by activating Akt and Erk1/2 pathways.
  7. Although no change in SULF2 was detected in squamous cell carcinoma of the head and neck (HNSCC) serum, its detection in saliva makes it worthy of further investigation as a potential HNSCC biomarker.
    Title: Expression of the extracellular sulfatase SULF2 is associated with squamous cell carcinoma of the head and neck.
  8. results demonstrated that SULF2 can mediate the detrimental effects of ionizing radiation in vivo
    Title: Involvement of SULF2 in y-irradiation-induced invasion and resistance of cancer cells by inducing IL-6 expression.
  9. The short variants of Sulf2 promoted FGF2-induced MDA-MB231 and MCF7 in vitro growth while full-length Sulf1 inhibited growth supporting in vivo mammary tumour cell signalling patterns of growth.
    Title: Short SULF1/SULF2 splice variants predominate in mammary tumours with a potential to facilitate receptor tyrosine kinase-mediated cell signalling.
  10. Most pancreatic ductal adenocarcinomas had positive SULF2 staining in tumour cells and intratumoural or tumour-adjacent stroma. Elevated SULF2 in PDAC was associated with advanced tumour stage, vascular invasion, shorter interval to radiological progression and shorter overall survival.
    Title: Sulfatase-2: a prognostic biomarker and candidate therapeutic target in patients with pancreatic ductal adenocarcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (51)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Common variation in GPC5 is associated with acquired nephrotic syndrome.
NHGRI GWA Catalog
Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ44488, FLJ90554, KIAA1247, MGC126411, DKFZp313E091

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetylglucosamine-6-sulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
N-acetylglucosamine-6-sulfatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
N-acetylglucosamine-6-sulfatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
arylsulfatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
arylsulfatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
bone development ISS
Inferred from Sequence or Structural Similarity
more info
  
cartilage development ISS
Inferred from Sequence or Structural Similarity
more info
  
chondrocyte development ISS
Inferred from Sequence or Structural Similarity
more info
  
embryonic skeletal system development ISS
Inferred from Sequence or Structural Similarity
more info
  
esophagus smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
  
glial cell-derived neurotrophic factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
glomerular basement membrane development IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
glomerular basement membrane development ISS
Inferred from Sequence or Structural Similarity
more info
  
glomerular filtration ISS
Inferred from Sequence or Structural Similarity
more info
  
heparan sulfate proteoglycan metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
heparan sulfate proteoglycan metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
heparan sulfate proteoglycan metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
innervation ISS
Inferred from Sequence or Structural Similarity
more info
  
kidney development ISS
Inferred from Sequence or Structural Similarity
more info
  
liver regeneration IEA
Inferred from Electronic Annotation
more info
  
negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
negative regulation of fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
positive regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
positive regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
positive regulation of vascular endothelial growth factor production IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
positive regulation of vascular endothelial growth factor production ISS
Inferred from Sequence or Structural Similarity
more info
  
regulation of hepatocyte proliferation IEA
Inferred from Electronic Annotation
more info
  
response to wounding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
Golgi stack IEA
Inferred from Electronic Annotation
more info
  
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
extracellular space NAS
Non-traceable Author Statement
more info
 PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
extracellular sulfatase Sulf-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161841.1 → NP_001155313.1  extracellular sulfatase Sulf-2 isoform a precursor

    See identical proteins and their annotated locations for NP_001155313.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AI824415, AL550624, AY101176, BC110539, CD673642, CR749319
    Consensus CDS
    CCDS13408.1
    UniProtKB/Swiss-Prot
    Q8IWU5
    Related
    ENSP00000418290.1, ENST00000484875.5
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 662
    DUF3740; Sulfatase protein
    cl23718
    Location:749 → 798
    ALP_like; alkaline phosphatases and sulfatases

  2. NM_018837.3 → NP_061325.1  extracellular sulfatase Sulf-2 isoform a precursor

    See identical proteins and their annotated locations for NP_061325.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Both variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AB033073, AI824415, BC110539, CD673642
    Consensus CDS
    CCDS13408.1
    UniProtKB/Swiss-Prot
    Q8IWU5
    Related
    ENSP00000353007.4, ENST00000359930.8
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 662
    DUF3740; Sulfatase protein
    cl23718
    Location:749 → 798
    ALP_like; alkaline phosphatases and sulfatases

  3. NM_198596.2 → NP_940998.2  extracellular sulfatase Sulf-2 isoform b precursor

    See identical proteins and their annotated locations for NP_940998.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and includes an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AI824415, AL550624, AY101176, AY358461, CD673642
    Consensus CDS
    CCDS13409.2
    UniProtKB/Swiss-Prot
    Q8IWU5
    Related
    ENSP00000418442.1, ENST00000467815.5
    Conserved Domains (4) summary
    COG3119
    Location:43 → 395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535 → 661
    DUF3740; Sulfatase protein
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:749 → 798
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    47654569..47786616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260458.3 → XP_005260515.1  extracellular sulfatase Sulf-2 isoform X3

    See identical proteins and their annotated locations for XP_005260515.1

    UniProtKB/Swiss-Prot
    Q8IWU5
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 662
    DUF3740; Sulfatase protein
    cl23718
    Location:749 → 798
    ALP_like; alkaline phosphatases and sulfatases

  2. XM_017027955.2 → XP_016883444.1  extracellular sulfatase Sulf-2 isoform X3

    UniProtKB/Swiss-Prot
    Q8IWU5
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 662
    DUF3740; Sulfatase protein
    cl23718
    Location:749 → 798
    ALP_like; alkaline phosphatases and sulfatases

  3. XM_011528916.2 → XP_011527218.1  extracellular sulfatase Sulf-2 isoform X6

    See identical proteins and their annotated locations for XP_011527218.1

    Conserved Domains (4) summary
    COG3119
    Location:43 → 395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535 → 661
    DUF3740; Sulfatase protein
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:749 → 798
    ALP_like; alkaline phosphatases and sulfatases

  4. XM_006723828.2 → XP_006723891.1  extracellular sulfatase Sulf-2 isoform X1

    See identical proteins and their annotated locations for XP_006723891.1

    Conserved Domains (4) summary
    COG3119
    Location:43 → 395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535 → 662
    DUF3740; Sulfatase protein
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:750 → 799
    ALP_like; alkaline phosphatases and sulfatases

  5. XM_006723829.3 → XP_006723892.1  extracellular sulfatase Sulf-2 isoform X1

    See identical proteins and their annotated locations for XP_006723892.1

    Conserved Domains (4) summary
    COG3119
    Location:43 → 395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535 → 662
    DUF3740; Sulfatase protein
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:750 → 799
    ALP_like; alkaline phosphatases and sulfatases

  6. XM_006723830.2 → XP_006723893.1  extracellular sulfatase Sulf-2 isoform X4

    See identical proteins and their annotated locations for XP_006723893.1

    UniProtKB/Swiss-Prot
    Q8IWU5
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 662
    DUF3740; Sulfatase protein
    cl23718
    Location:749 → 798
    ALP_like; alkaline phosphatases and sulfatases

  7. XM_011528914.2 → XP_011527216.1  extracellular sulfatase Sulf-2 isoform X2

    See identical proteins and their annotated locations for XP_011527216.1

    Conserved Domains (4) summary
    COG3119
    Location:43 → 395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535 → 662
    DUF3740; Sulfatase protein
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:750 → 799
    ALP_like; alkaline phosphatases and sulfatases

  8. XM_011528915.2 → XP_011527217.1  extracellular sulfatase Sulf-2 isoform X5

    Conserved Domains (4) summary
    COG3119
    Location:43 → 395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535 → 662
    DUF3740; Sulfatase protein
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:750 → 799
    ALP_like; alkaline phosphatases and sulfatases

  9. XM_006723827.2 → XP_006723890.1  extracellular sulfatase Sulf-2 isoform X1

    See identical proteins and their annotated locations for XP_006723890.1

    Conserved Domains (4) summary
    COG3119
    Location:43 → 395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535 → 662
    DUF3740; Sulfatase protein
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:750 → 799
    ALP_like; alkaline phosphatases and sulfatases

  10. XM_011528913.1 → XP_011527215.1  extracellular sulfatase Sulf-2 isoform X1

    See identical proteins and their annotated locations for XP_011527215.1

    Conserved Domains (4) summary
    COG3119
    Location:43 → 395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535 → 662
    DUF3740; Sulfatase protein
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:750 → 799
    ALP_like; alkaline phosphatases and sulfatases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IWU5.1 GenPept UniProtKB/Swiss-Prot:Q8IWU5

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