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SULF2 sulfatase 2 [ Homo sapiens (human) ]

Gene ID: 55959, updated on 4-Jul-2021

Summary

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Official Symbol
SULF2provided by HGNC
Official Full Name
sulfatase 2provided by HGNC
Primary source
HGNC:HGNC:20392
See related
Ensembl:ENSG00000196562 MIM:610013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSULF-2
Summary
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in ovary (RPKM 36.9), endometrium (RPKM 36.6) and 24 other tissues See more
Orthologs
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Genomic context

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See SULF2 in Genome Data Viewer
Location:
20q13.12
Exon count:
24
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (47657406..47786627, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (46286150..46415371, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 3 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene nuclear receptor coactivator 3 repeat instability region Neighboring gene uncharacterized LOC107985401 Neighboring gene RNA, U7 small nuclear 173 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Recapitulation of pharmacogenomic data reveals that invalidation of SULF2 enhance sorafenib susceptibility in liver cancer. Yoon S, et al. Oncogene, 2018 Aug. PMID 29720727
  2. Sulfatase-2 promotes the growth and metastasis of colorectal cancer by activating Akt and Erk1/2 pathways. Tao Y, et al. Biomed Pharmacother, 2017 May. PMID 28320104
  3. Evaluating Tumor-Associated Activity of Extracellular Sulfatase by Analyzing Naturally Occurring Substrate in Tumor Microenvironment of Hepatocellular Carcinoma. Yu Y, et al. Anal Chem, 2016 Dec 20. PMID 28193024
  4. Impact of Sulfatase-2 on cancer progression and prognosis in patients with renal cell carcinoma. Kumagai S, et al. Cancer Sci, 2016 Nov. PMID 27589337, Free PMC Article
  5. Sulfatase-2: a prognostic biomarker and candidate therapeutic target in patients with pancreatic ductal adenocarcinoma. Alhasan SF, et al. Br J Cancer, 2016 Sep 27. PMID 27560551, Free PMC Article

See all (73) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-527 targeting SULF2 down-regulates SULF2 expression, concurrently, suppresses NSCLC epithelial-mesenchymal transition and invasion via inhibiting TGF-beta/SMAD signaling pathway in non-small-cell lung cancer
    Title: MicroRNA-527 inhibits TGF-β/SMAD induced epithelial-mesenchymal transition via downregulating SULF2 expression in non-small-cell lung cancer.
  2. TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment
    Title: TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment.
  3. Loss of SULF2 expression is associated with corticospinal tract defect.
    Title: Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.
  4. SULF2 plays a key role in sorafenib susceptibility.
    Title: Recapitulation of pharmacogenomic data reveals that invalidation of SULF2 enhance sorafenib susceptibility in liver cancer.
  5. High SULF2 expression is associated with glioma.
    Title: Multi-tasking Sulf1/Sulf2 enzymes do not only facilitate extracellular cell signalling but also participate in cell cycle related nuclear events.
  6. The activity of sulfatase 2, a major form of endosulfatase in hepatocellular carcinoma can be studied, in connection with the interactions between heparan sulfate and various growth factors.
    Title: Evaluating Tumor-Associated Activity of Extracellular Sulfatase by Analyzing Naturally Occurring Substrate in Tumor Microenvironment of Hepatocellular Carcinoma.
  7. SULF2 promotes the growth and metastasis of CRC probably by activating Akt and Erk1/2 pathways.
    Title: Sulfatase-2 promotes the growth and metastasis of colorectal cancer by activating Akt and Erk1/2 pathways.
  8. Although no change in SULF2 was detected in squamous cell carcinoma of the head and neck (HNSCC) serum, its detection in saliva makes it worthy of further investigation as a potential HNSCC biomarker.
    Title: Expression of the extracellular sulfatase SULF2 is associated with squamous cell carcinoma of the head and neck.
  9. results demonstrated that SULF2 can mediate the detrimental effects of ionizing radiation in vivo
    Title: Involvement of SULF2 in y-irradiation-induced invasion and resistance of cancer cells by inducing IL-6 expression.
  10. The short variants of Sulf2 promoted FGF2-induced MDA-MB231 and MCF7 in vitro growth while full-length Sulf1 inhibited growth supporting in vivo mammary tumour cell signalling patterns of growth.
    Title: Short SULF1/SULF2 splice variants predominate in mammary tumours with a potential to facilitate receptor tyrosine kinase-mediated cell signalling.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Common variation in GPC5 is associated with acquired nephrotic syndrome.
GeneReviews: Not available
Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ44488, FLJ90554, KIAA1247, MGC126411, DKFZp313E091

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetylglucosamine-6-sulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables N-acetylglucosamine-6-sulfatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetylglucosamine-6-sulfatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables arylsulfatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arylsulfatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in bone development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cartilage development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chondrocyte development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in embryonic skeletal system development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in esophagus smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glial cell-derived neurotrophic factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glomerular basement membrane development IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in glomerular basement membrane development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glomerular filtration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heparan sulfate proteoglycan metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in heparan sulfate proteoglycan metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heparan sulfate proteoglycan metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in innervation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in kidney development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in liver regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of vascular endothelial growth factor production IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of vascular endothelial growth factor production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of hepatocyte proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to wounding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
extracellular sulfatase Sulf-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161841.2 → NP_001155313.1  extracellular sulfatase Sulf-2 isoform a precursor

    See identical proteins and their annotated locations for NP_001155313.1

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Consensus CDS
    CCDS13408.1
    UniProtKB/Swiss-Prot
    Q8IWU5
    Related
    ENSP00000418290.1, ENST00000484875.5
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 661
    DUF3740; Sulfatase protein
    cl23718
    Location:749 → 798
    ALP_like; alkaline phosphatases and sulfatases

  2. NM_001387048.1 → NP_001373977.1  extracellular sulfatase Sulf-2 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 661
    DUF3740; Sulfatase protein
    cl23718
    Location:749 → 798
    ALP_like; alkaline phosphatases and sulfatases

  3. NM_001387049.1 → NP_001373978.1  extracellular sulfatase Sulf-2 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 661
    DUF3740; Sulfatase protein
    cl23718
    Location:749 → 798
    ALP_like; alkaline phosphatases and sulfatases

  4. NM_001387050.1 → NP_001373979.1  extracellular sulfatase Sulf-2 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 662
    DUF3740; Sulfatase protein
    cl23718
    Location:750 → 799
    ALP_like; alkaline phosphatases and sulfatases

  5. NM_001387051.1 → NP_001373980.1  extracellular sulfatase Sulf-2 isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 661
    DUF3740; Sulfatase protein
    cl23718
    Location:749 → 798
    ALP_like; alkaline phosphatases and sulfatases

  6. NM_001387052.1 → NP_001373981.1  extracellular sulfatase Sulf-2 isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 662
    DUF3740; Sulfatase protein
    cl23718
    Location:750 → 799
    ALP_like; alkaline phosphatases and sulfatases

  7. NM_001387053.1 → NP_001373982.1  extracellular sulfatase Sulf-2 isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 662
    DUF3740; Sulfatase protein
    cl23718
    Location:750 → 799
    ALP_like; alkaline phosphatases and sulfatases

  8. NM_001387054.1 → NP_001373983.1  extracellular sulfatase Sulf-2 isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 662
    DUF3740; Sulfatase protein
    cl23718
    Location:750 → 799
    ALP_like; alkaline phosphatases and sulfatases

  9. NM_001387055.1 → NP_001373984.1  extracellular sulfatase Sulf-2 isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 662
    DUF3740; Sulfatase protein
    cl23718
    Location:750 → 799
    ALP_like; alkaline phosphatases and sulfatases

  10. NM_018837.4 → NP_061325.1  extracellular sulfatase Sulf-2 isoform a precursor

    See identical proteins and their annotated locations for NP_061325.1

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Consensus CDS
    CCDS13408.1
    UniProtKB/Swiss-Prot
    Q8IWU5
    Related
    ENSP00000353007.4, ENST00000359930.8
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 661
    DUF3740; Sulfatase protein
    cl23718
    Location:749 → 798
    ALP_like; alkaline phosphatases and sulfatases

  11. NM_198596.3 → NP_940998.2  extracellular sulfatase Sulf-2 isoform b precursor

    See identical proteins and their annotated locations for NP_940998.2

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Consensus CDS
    CCDS13409.2
    UniProtKB/Swiss-Prot
    Q8IWU5
    Related
    ENSP00000418442.1, ENST00000467815.5
    Conserved Domains (4) summary
    COG3119
    Location:43 → 395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535 → 661
    DUF3740; Sulfatase protein
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:749 → 798
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    47657406..47786627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723830.2 → XP_006723893.1  extracellular sulfatase Sulf-2 isoform X4

    See identical proteins and their annotated locations for XP_006723893.1

    UniProtKB/Swiss-Prot
    Q8IWU5
    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 661
    DUF3740; Sulfatase protein
    cl23718
    Location:749 → 798
    ALP_like; alkaline phosphatases and sulfatases

  2. XM_011528914.2 → XP_011527216.1  extracellular sulfatase Sulf-2 isoform X2

    See identical proteins and their annotated locations for XP_011527216.1

    Conserved Domains (3) summary
    cd16147
    Location:43 → 385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529 → 662
    DUF3740; Sulfatase protein
    cl23718
    Location:750 → 799
    ALP_like; alkaline phosphatases and sulfatases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IWU5.1 GenPept UniProtKB/Swiss-Prot:Q8IWU5

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