SULF2 sulfatase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SULF2provided by HGNC
Official Full Name: sulfatase 2provided by HGNC
Primary source: HGNC:HGNC:20392
See related: Ensembl:ENSG00000196562 MIM:610013; AllianceGenome:HGNC:20392
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSULF-2
Summary: Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Expression: Ubiquitous expression in ovary (RPKM 36.9), endometrium (RPKM 36.6) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.12

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (47657406..47786627, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (49395801..49525734, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (46286150..46415371, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Galectin-3-Binding Protein Inhibits Extracellular Heparan 6-O-Endosulfatase Sulf-2.
Title: Galectin-3-Binding Protein Inhibits Extracellular Heparan 6-O-Endosulfatase Sulf-2.
Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-alpha-induced inflammatory activation of synovial fibroblasts.
Title: Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-α-induced inflammatory activation of synovial fibroblasts.
SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.
Title: SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.
Extracellular sulfatases as potential blood-based biomarkers for early detection of lung cancer.
Title: Extracellular sulfatases as potential blood-based biomarkers for early detection of lung cancer.
Sulfatase 2 (SULF2) Monoclonal Antibody 5D5 Suppresses Human Cholangiocarcinoma Xenograft Growth Through Regulation of a SULF2-Platelet-Derived Growth Factor Receptor Beta-Yes-Associated Protein Signaling Axis.
Title: Sulfatase 2 (SULF2) Monoclonal Antibody 5D5 Suppresses Human Cholangiocarcinoma Xenograft Growth Through Regulation of a SULF2-Platelet-Derived Growth Factor Receptor Beta-Yes-Associated Protein Signaling Axis.
miR-527 targeting SULF2 down-regulates SULF2 expression, concurrently, suppresses NSCLC epithelial-mesenchymal transition and invasion via inhibiting TGF-beta/SMAD signaling pathway in non-small-cell lung cancer
Title: MicroRNA-527 inhibits TGF-β/SMAD induced epithelial-mesenchymal transition via downregulating SULF2 expression in non-small-cell lung cancer.
TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment
Title: TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment.
Loss of SULF2 expression is associated with corticospinal tract defect.
Title: Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.
SULF2 plays a key role in sorafenib susceptibility.
Title: Recapitulation of pharmacogenomic data reveals that invalidation of SULF2 enhance sorafenib susceptibility in liver cancer.
High SULF2 expression is associated with glioma.
Title: Multi-tasking Sulf1/Sulf2 enzymes do not only facilitate extracellular cell signalling but also participate in cell cycle related nuclear events.

Submit: New GeneRIF Correction See all GeneRIFs (57)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variation in GPC5 is associated with acquired nephrotic syndrome. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93899 (e-PCR)
- UniSTS:88859

SHGC-149737 (e-PCR)
- UniSTS:177188

STS-N26808 (e-PCR)
- UniSTS:68844

SHGC-85658 (e-PCR)
- UniSTS:170229

Clone Names

FLJ44488, FLJ90554, KIAA1247, MGC126411, DKFZp313E091

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables N-acetylglucosamine-6-sulfatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetylglucosamine-6-sulfatase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetylglucosamine-6-sulfatase activity	IEA Inferred from Electronic Annotation more info
enables N-acetylglucosamine-6-sulfatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables arylsulfatase activity	IDA Inferred from Direct Assay more info	PubMed
enables arylsulfatase activity	IEA Inferred from Electronic Annotation more info
enables arylsulfatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables glycosaminoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sulfuric ester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bone development	IEA Inferred from Electronic Annotation more info
involved_in bone development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in cartilage development	ISS Inferred from Sequence or Structural Similarity more info
involved_in chondrocyte development	IEA Inferred from Electronic Annotation more info
involved_in chondrocyte development	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic skeletal system development	IEA Inferred from Electronic Annotation more info
involved_in embryonic skeletal system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in esophagus smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in esophagus smooth muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerular basement membrane development	IBA Inferred from Biological aspect of Ancestor more info
involved_in glomerular basement membrane development	IEA Inferred from Electronic Annotation more info
involved_in glomerular basement membrane development	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerular filtration	IEA Inferred from Electronic Annotation more info
involved_in glomerular filtration	ISS Inferred from Sequence or Structural Similarity more info
involved_in heparan sulfate proteoglycan metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heparan sulfate proteoglycan metabolic process	IEA Inferred from Electronic Annotation more info
involved_in heparan sulfate proteoglycan metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in innervation	IEA Inferred from Electronic Annotation more info
involved_in innervation	ISS Inferred from Sequence or Structural Similarity more info
involved_in kidney development	IEA Inferred from Electronic Annotation more info
involved_in kidney development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within liver regeneration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelin production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of hepatocyte proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to wounding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IMP Inferred from Mutant Phenotype more info	PubMed
located_in extracellular space	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: extracellular sulfatase Sulf-2

Names: N-acetylglucosamine-6-sulfatase; arylsulfatase

NP_001155313.1

EC 3.1.6.1

EC 3.1.6.14

NP_001373977.1

EC 3.1.6.1

EC 3.1.6.14

NP_001373978.1

EC 3.1.6.1

EC 3.1.6.14

NP_001373979.1

EC 3.1.6.1

EC 3.1.6.14

NP_001373980.1

EC 3.1.6.1

EC 3.1.6.14

NP_001373981.1

EC 3.1.6.1

EC 3.1.6.14

NP_001373982.1

EC 3.1.6.1

EC 3.1.6.14

NP_001373983.1

EC 3.1.6.1

EC 3.1.6.14

NP_001373984.1

EC 3.1.6.1

EC 3.1.6.14

NP_061325.1

EC 3.1.6.1

EC 3.1.6.14

NP_940998.2

EC 3.1.6.1

EC 3.1.6.14

XP_047296251.1

EC 3.1.6.1

EC 3.1.6.14

XP_047296252.1

EC 3.1.6.1

EC 3.1.6.14

XP_047296253.1

EC 3.1.6.1

EC 3.1.6.14

XP_047296254.1

EC 3.1.6.1

EC 3.1.6.14

XP_047296255.1

EC 3.1.6.1

EC 3.1.6.14

XP_047296256.1

EC 3.1.6.1

EC 3.1.6.14

XP_047296257.1

EC 3.1.6.1

EC 3.1.6.14

XP_054179677.1

EC 3.1.6.1

EC 3.1.6.14

XP_054179678.1

EC 3.1.6.1

EC 3.1.6.14

XP_054179679.1

EC 3.1.6.1

EC 3.1.6.14

XP_054179680.1

EC 3.1.6.1

EC 3.1.6.14

XP_054179681.1

EC 3.1.6.1

EC 3.1.6.14

XP_054179682.1

EC 3.1.6.1

EC 3.1.6.14

XP_054179683.1

EC 3.1.6.1

EC 3.1.6.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161841.2 → NP_001155313.1 extracellular sulfatase Sulf-2 isoform a precursor

See identical proteins and their annotated locations for NP_001155313.1

Status: VALIDATED

Source sequence(s)

AL034418, AL121777, AL354813

Consensus CDS

CCDS13408.1

UniProtKB/Swiss-Prot

E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3

Related

ENSP00000418290.1, ENST00000484875.5

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:529 → 661

DUF3740; Sulfatase protein

cl23718
Location:749 → 798

ALP_like; alkaline phosphatases and sulfatases
NM_001387048.1 → NP_001373977.1 extracellular sulfatase Sulf-2 isoform a precursor

Status: VALIDATED

Source sequence(s)

AL034418, AL121777, AL354813

Consensus CDS

CCDS13408.1

UniProtKB/Swiss-Prot

E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3

Related

ENSP00000508753.1, ENST00000688720.1

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:529 → 661

DUF3740; Sulfatase protein

cl23718
Location:749 → 798

ALP_like; alkaline phosphatases and sulfatases
NM_001387049.1 → NP_001373978.1 extracellular sulfatase Sulf-2 isoform a precursor

Status: VALIDATED

Source sequence(s)

AL034418, AL121777, AL354813

Consensus CDS

CCDS13408.1

UniProtKB/Swiss-Prot

E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:529 → 661

DUF3740; Sulfatase protein

cl23718
Location:749 → 798

ALP_like; alkaline phosphatases and sulfatases
NM_001387050.1 → NP_001373979.1 extracellular sulfatase Sulf-2 isoform c precursor

Status: VALIDATED

Source sequence(s)

AL034418, AL121777, AL354813

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:529 → 662

DUF3740; Sulfatase protein

cl23718
Location:750 → 799

ALP_like; alkaline phosphatases and sulfatases
NM_001387051.1 → NP_001373980.1 extracellular sulfatase Sulf-2 isoform d precursor

Status: VALIDATED

Source sequence(s)

AL034418, AL121777, AL354813

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:529 → 661

DUF3740; Sulfatase protein

cl23718
Location:749 → 798

ALP_like; alkaline phosphatases and sulfatases
NM_001387052.1 → NP_001373981.1 extracellular sulfatase Sulf-2 isoform e precursor

Status: VALIDATED

Source sequence(s)

AL034418, AL121777, AL354813

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:529 → 662

DUF3740; Sulfatase protein

cl23718
Location:750 → 799

ALP_like; alkaline phosphatases and sulfatases
NM_001387053.1 → NP_001373982.1 extracellular sulfatase Sulf-2 isoform e precursor

Status: VALIDATED

Source sequence(s)

AL034418, AL121777, AL354813

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:529 → 662

DUF3740; Sulfatase protein

cl23718
Location:750 → 799

ALP_like; alkaline phosphatases and sulfatases
NM_001387054.1 → NP_001373983.1 extracellular sulfatase Sulf-2 isoform e precursor

Status: VALIDATED

Source sequence(s)

AL034418, AL121777, AL354813

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:529 → 662

DUF3740; Sulfatase protein

cl23718
Location:750 → 799

ALP_like; alkaline phosphatases and sulfatases
NM_001387055.1 → NP_001373984.1 extracellular sulfatase Sulf-2 isoform e precursor

Status: VALIDATED

Source sequence(s)

AL034418, AL121777, AL354813

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:529 → 662

DUF3740; Sulfatase protein

cl23718
Location:750 → 799

ALP_like; alkaline phosphatases and sulfatases
NM_018837.4 → NP_061325.1 extracellular sulfatase Sulf-2 isoform a precursor

See identical proteins and their annotated locations for NP_061325.1

Status: VALIDATED

Source sequence(s)

AL034418, AL121777, AL354813

Consensus CDS

CCDS13408.1

UniProtKB/Swiss-Prot

E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3

Related

ENSP00000353007.4, ENST00000359930.8

Conserved Domains (3) summary

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:529 → 661

DUF3740; Sulfatase protein

cl23718
Location:749 → 798

ALP_like; alkaline phosphatases and sulfatases
NM_198596.3 → NP_940998.2 extracellular sulfatase Sulf-2 isoform b precursor

See identical proteins and their annotated locations for NP_940998.2

Status: VALIDATED

Source sequence(s)

AL034418, AL121777, AL354813

Consensus CDS

CCDS13409.2

UniProtKB/Swiss-Prot

Q8IWU5

Related

ENSP00000418442.1, ENST00000467815.5

Conserved Domains (4) summary

COG3119
Location:43 → 395

AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]

pfam12548
Location:535 → 661

DUF3740; Sulfatase protein

cd16147
Location:43 → 385

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

cl23718
Location:749 → 798

ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

47657406..47786627 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047440296.1 → XP_047296252.1 extracellular sulfatase Sulf-2 isoform X2

UniProtKB/Swiss-Prot

E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3
XM_047440295.1 → XP_047296251.1 extracellular sulfatase Sulf-2 isoform X1
XM_047440297.1 → XP_047296253.1 extracellular sulfatase Sulf-2 isoform X3
XM_047440300.1 → XP_047296256.1 extracellular sulfatase Sulf-2 isoform X4
XM_047440298.1 → XP_047296254.1 extracellular sulfatase Sulf-2 isoform X3
XM_047440299.1 → XP_047296255.1 extracellular sulfatase Sulf-2 isoform X4
XM_047440301.1 → XP_047296257.1 extracellular sulfatase Sulf-2 isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060944.1 Alternate T2T-CHM13v2.0

Range

49395801..49525734 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054323703.1 → XP_054179678.1 extracellular sulfatase Sulf-2 isoform X6

UniProtKB/Swiss-Prot

E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3
XM_054323702.1 → XP_054179677.1 extracellular sulfatase Sulf-2 isoform X5
XM_054323704.1 → XP_054179679.1 extracellular sulfatase Sulf-2 isoform X3
XM_054323706.1 → XP_054179681.1 extracellular sulfatase Sulf-2 isoform X4
XM_054323705.1 → XP_054179680.1 extracellular sulfatase Sulf-2 isoform X3
XM_054323707.1 → XP_054179682.1 extracellular sulfatase Sulf-2 isoform X4
XM_054323708.1 → XP_054179683.1 extracellular sulfatase Sulf-2 isoform X4