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SULF2 sulfatase 2 [ Homo sapiens (human) ]

Gene ID: 55959, updated on 1-Jun-2020

Summary

Official Symbol
SULF2provided by HGNC
Official Full Name
sulfatase 2provided by HGNC
Primary source
HGNC:HGNC:20392
See related
Ensembl:ENSG00000196562 MIM:610013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSULF-2
Summary
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in ovary (RPKM 36.9), endometrium (RPKM 36.6) and 24 other tissues See more
Orthologs

Genomic context

See SULF2 in Genome Data Viewer
Location:
20q13.12
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (47654569..47786616, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (46286150..46415360, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 3 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene nuclear receptor coactivator 3 repeat instability region Neighboring gene uncharacterized LOC107985401 Neighboring gene RNA, U7 small nuclear 173 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variation in GPC5 is associated with acquired nephrotic syndrome.
NHGRI GWA Catalog
Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44488, FLJ90554, KIAA1247, MGC126411, DKFZp313E091

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetylglucosamine-6-sulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-acetylglucosamine-6-sulfatase activity IDA
Inferred from Direct Assay
more info
PubMed 
N-acetylglucosamine-6-sulfatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
arylsulfatase activity IDA
Inferred from Direct Assay
more info
PubMed 
arylsulfatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
bone development ISS
Inferred from Sequence or Structural Similarity
more info
 
cartilage development ISS
Inferred from Sequence or Structural Similarity
more info
 
chondrocyte development ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic skeletal system development ISS
Inferred from Sequence or Structural Similarity
more info
 
esophagus smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
glial cell-derived neurotrophic factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
glomerular basement membrane development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glomerular basement membrane development ISS
Inferred from Sequence or Structural Similarity
more info
 
glomerular filtration ISS
Inferred from Sequence or Structural Similarity
more info
 
heparan sulfate proteoglycan metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparan sulfate proteoglycan metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
heparan sulfate proteoglycan metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
innervation ISS
Inferred from Sequence or Structural Similarity
more info
 
kidney development ISS
Inferred from Sequence or Structural Similarity
more info
 
liver regeneration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular endothelial growth factor production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of vascular endothelial growth factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of hepatocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
response to wounding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi stack IEA
Inferred from Electronic Annotation
more info
 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
extracellular sulfatase Sulf-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161841.1NP_001155313.1  extracellular sulfatase Sulf-2 isoform a precursor

    See identical proteins and their annotated locations for NP_001155313.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AI824415, AL550624, AY101176, BC110539, CD673642, CR749319
    Consensus CDS
    CCDS13408.1
    UniProtKB/Swiss-Prot
    Q8IWU5
    Related
    ENSP00000418290.1, ENST00000484875.5
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529662
    DUF3740; Sulfatase protein
    cl23718
    Location:749798
    ALP_like; alkaline phosphatases and sulfatases
  2. NM_018837.3NP_061325.1  extracellular sulfatase Sulf-2 isoform a precursor

    See identical proteins and their annotated locations for NP_061325.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Both variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AB033073, AI824415, BC110539, CD673642
    Consensus CDS
    CCDS13408.1
    UniProtKB/Swiss-Prot
    Q8IWU5
    Related
    ENSP00000353007.4, ENST00000359930.8
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529662
    DUF3740; Sulfatase protein
    cl23718
    Location:749798
    ALP_like; alkaline phosphatases and sulfatases
  3. NM_198596.2NP_940998.2  extracellular sulfatase Sulf-2 isoform b precursor

    See identical proteins and their annotated locations for NP_940998.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and includes an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AI824415, AL550624, AY101176, AY358461, CD673642
    Consensus CDS
    CCDS13409.2
    UniProtKB/Swiss-Prot
    Q8IWU5
    Related
    ENSP00000418442.1, ENST00000467815.5
    Conserved Domains (4) summary
    COG3119
    Location:43395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535661
    DUF3740; Sulfatase protein
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:749798
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    47654569..47786616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260458.3XP_005260515.1  extracellular sulfatase Sulf-2 isoform X3

    See identical proteins and their annotated locations for XP_005260515.1

    UniProtKB/Swiss-Prot
    Q8IWU5
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529662
    DUF3740; Sulfatase protein
    cl23718
    Location:749798
    ALP_like; alkaline phosphatases and sulfatases
  2. XM_017027955.2XP_016883444.1  extracellular sulfatase Sulf-2 isoform X3

    UniProtKB/Swiss-Prot
    Q8IWU5
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529662
    DUF3740; Sulfatase protein
    cl23718
    Location:749798
    ALP_like; alkaline phosphatases and sulfatases
  3. XM_011528916.2XP_011527218.1  extracellular sulfatase Sulf-2 isoform X6

    See identical proteins and their annotated locations for XP_011527218.1

    Conserved Domains (4) summary
    COG3119
    Location:43395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535661
    DUF3740; Sulfatase protein
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:749798
    ALP_like; alkaline phosphatases and sulfatases
  4. XM_006723828.2XP_006723891.1  extracellular sulfatase Sulf-2 isoform X1

    See identical proteins and their annotated locations for XP_006723891.1

    Conserved Domains (4) summary
    COG3119
    Location:43395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535662
    DUF3740; Sulfatase protein
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:750799
    ALP_like; alkaline phosphatases and sulfatases
  5. XM_006723829.3XP_006723892.1  extracellular sulfatase Sulf-2 isoform X1

    See identical proteins and their annotated locations for XP_006723892.1

    Conserved Domains (4) summary
    COG3119
    Location:43395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535662
    DUF3740; Sulfatase protein
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:750799
    ALP_like; alkaline phosphatases and sulfatases
  6. XM_006723830.2XP_006723893.1  extracellular sulfatase Sulf-2 isoform X4

    See identical proteins and their annotated locations for XP_006723893.1

    UniProtKB/Swiss-Prot
    Q8IWU5
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529662
    DUF3740; Sulfatase protein
    cl23718
    Location:749798
    ALP_like; alkaline phosphatases and sulfatases
  7. XM_011528914.2XP_011527216.1  extracellular sulfatase Sulf-2 isoform X2

    See identical proteins and their annotated locations for XP_011527216.1

    Conserved Domains (4) summary
    COG3119
    Location:43395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535662
    DUF3740; Sulfatase protein
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:750799
    ALP_like; alkaline phosphatases and sulfatases
  8. XM_011528915.2XP_011527217.1  extracellular sulfatase Sulf-2 isoform X5

    Conserved Domains (4) summary
    COG3119
    Location:43395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535662
    DUF3740; Sulfatase protein
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:750799
    ALP_like; alkaline phosphatases and sulfatases
  9. XM_006723827.2XP_006723890.1  extracellular sulfatase Sulf-2 isoform X1

    See identical proteins and their annotated locations for XP_006723890.1

    Conserved Domains (4) summary
    COG3119
    Location:43395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535662
    DUF3740; Sulfatase protein
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:750799
    ALP_like; alkaline phosphatases and sulfatases
  10. XM_011528913.1XP_011527215.1  extracellular sulfatase Sulf-2 isoform X1

    See identical proteins and their annotated locations for XP_011527215.1

    Conserved Domains (4) summary
    COG3119
    Location:43395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535662
    DUF3740; Sulfatase protein
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:750799
    ALP_like; alkaline phosphatases and sulfatases
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