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LIN37 lin-37 DREAM MuvB core complex component [ Homo sapiens (human) ]

Gene ID: 55957, updated on 7-Jun-2020

Summary

Official Symbol
LIN37provided by HGNC
Official Full Name
lin-37 DREAM MuvB core complex componentprovided by HGNC
Primary source
HGNC:HGNC:33234
See related
Ensembl:ENSG00000267796
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
F25965; lin-37; ZK418.4
Summary
This gene encodes a protein expressed in the eye. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 7.7), placenta (RPKM 6.8) and 25 other tissues See more
Orthologs

Genomic context

See LIN37 in Genome Data Viewer
Location:
19q13.12
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35748576..35754519)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36239262..36245420)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene U2 small nuclear RNA auxiliary factor 1 like 4 Neighboring gene presenilin enhancer, gamma-secretase subunit Neighboring gene heat shock protein family B (small) member 6 Neighboring gene proline and serine rich 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PSENEN

Homology

Clone Names

  • MGC9505

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Myb complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcriptional repressor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein lin-37 homolog
Names
antolefinin
lin-37 homolog
protein F25965

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369780.1NP_001356709.1  protein lin-37 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC002398, AD000671, KC877720, KC877725
    Conserved Domains (1) summary
    pfam15306
    Location:70226
    LIN37
  2. NM_019104.3NP_061977.1  protein lin-37 homolog isoform 1

    See identical proteins and their annotated locations for NP_061977.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC009071, CB152701, DC396639
    Consensus CDS
    CCDS62642.1
    UniProtKB/Swiss-Prot
    Q96GY3
    Related
    ENSP00000301159.7, ENST00000301159.14
    Conserved Domains (1) summary
    pfam15306
    Location:84240
    LIN37; LIN37

RNA

  1. NR_163146.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC002398, AD000671, KC877720, KC877725

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35748576..35754519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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