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scly selenocysteine lyase [ Danio rerio (zebrafish) ]

Gene ID: 559537, updated on 9-Sep-2025
Official Symbol
sclyprovided by ZNC
Official Full Name
selenocysteine lyaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080204-30
See related
Ensembl:ENSDARG00000073813 AllianceGenome:ZFIN:ZDB-GENE-080204-30
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:171514
Summary
Predicted to enable selenocysteine lyase activity. Predicted to be located in cytosol. Orthologous to human SCLY (selenocysteine lyase). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See scly in Genome Data Viewer
Location:
chromosome: 6
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 6 NC_133181.1 (29764986..29779580)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 6 NC_007117.7 (27275703..27290889)

Chromosome 6 - NC_133181.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141386283 Neighboring gene zgc:103559 Neighboring gene kinesin family member 1Aa Neighboring gene uncharacterized LOC141386285 Neighboring gene espin like a Neighboring gene kelch-like family member 30

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables selenocysteine lyase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
selenocysteine lyase
NP_001103853.1
XP_021332563.1
XP_068077839.1
XP_073809145.1
XP_073809146.1
XP_073809147.1
XP_073809148.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110383.1 → NP_001103853.1  selenocysteine lyase

    See identical proteins and their annotated locations for NP_001103853.1

    Status: PROVISIONAL

    Source sequence(s)
    BC154449
    UniProtKB/TrEMBL
    A0A8M1NEN6, A8WFT4
    Related
    ENSDARP00000099679.1, ENSDART00000114347.3
    Conserved Domains (1) summary
    COG1104
    Location:36 → 449
    NifS; Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133181.1 Reference GRCz12tu Primary Assembly

    Range
    29764986..29779580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073953047.1 → XP_073809148.1  selenocysteine lyase isoform X5

  2. XM_021476888.3 → XP_021332563.1  selenocysteine lyase isoform X2

    UniProtKB/TrEMBL
    A0A8M1NEN6, A8WFT4
    Conserved Domains (1) summary
    COG1104
    Location:36 → 449
    NifS; Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]

  3. XM_068221738.2 → XP_068077839.1  selenocysteine lyase isoform X3

    UniProtKB/TrEMBL
    A0AB32TR09

  4. XM_073953044.1 → XP_073809145.1  selenocysteine lyase isoform X1

  5. XM_073953046.1 → XP_073809147.1  selenocysteine lyase isoform X4

  6. XM_073953045.1 → XP_073809146.1  selenocysteine lyase isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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