Format

Send to:

Choose Destination

APOM apolipoprotein M [ Homo sapiens (human) ]

Gene ID: 55937, updated on 12-Oct-2019

Summary

Official Symbol
APOMprovided by HGNC
Official Full Name
apolipoprotein Mprovided by HGNC
Primary source
HGNC:HGNC:13916
See related
Ensembl:ENSG00000204444 MIM:606907
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G3a; NG20; apo-M; HSPC336
Summary
The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Alternate splicing results in both coding and non-coding variants of this gene. [provided by RefSeq, Jan 2012]
Expression
Biased expression in liver (RPKM 122.3), kidney (RPKM 73.7) and 1 other tissue See more
Orthologs

Genomic context

See APOM in Genome Data Viewer
Location:
6p21.33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (31652404..31658210)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (31620187..31625987)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene proline rich coiled-coil 2A Neighboring gene small nucleolar RNA, H/ACA box 38 Neighboring gene microRNA 6832 Neighboring gene BAG cochaperone 6 Neighboring gene chromosome 6 open reading frame 47 Neighboring gene G-patch domain and ankyrin repeats 1 Neighboring gene casein kinase 2 beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
NHGRI GWA Catalog
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
NHGRI GWA Catalog
Common variants at the promoter region of the APOM confer a risk of rheumatoid arthritis.
NHGRI GWA Catalog
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.
NHGRI GWA Catalog

Pathways from BioSystems

  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of fat-soluble vitamins, organism-specific biosystem (from REACTOME)
    Metabolism of fat-soluble vitamins, organism-specific biosystemVitamins A, D, E, and K are classified as fat-soluble. Metabolic pathways by which dietary precursors of vitamins A (Harrison 2005) and K(Shearer et al. 2012) are converted to active forms, and by wh...
  • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, classified according to their solubility, either fat-soluble or water-soluble, that are either not synthesized or synthesized only in limited amount...
  • Retinoid metabolism and transport, organism-specific biosystem (from REACTOME)
    Retinoid metabolism and transport, organism-specific biosystemVitamin A (all-trans-retinol) must be taken up, either as carotenes from plants, or as retinyl esters from animal food. The most prominent carotenes are alpha-carotene, lycopene, lutein, beta-cryptox...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Visual phototransduction, organism-specific biosystem (from REACTOME)
    Visual phototransduction, organism-specific biosystemVisual phototransduction is the process by which photon absorption by visual pigment molecules in photoreceptor cells is converted to an electrical cellular response. The events in this process are p...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC22400

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antioxidant activity IDA
Inferred from Direct Assay
more info
PubMed 
lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cholesterol efflux IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol homeostasis IC
Inferred by Curator
more info
PubMed 
high-density lipoprotein particle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
high-density lipoprotein particle assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
high-density lipoprotein particle clearance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
high-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
high-density lipoprotein particle remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
high-density lipoprotein particle remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of plasma lipoprotein oxidation IDA
Inferred from Direct Assay
more info
PubMed 
response to glucose IEA
Inferred from Electronic Annotation
more info
 
retinoid metabolic process TAS
Traceable Author Statement
more info
 
reverse cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
discoidal high-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
high-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
high-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
spherical high-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
very-low-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very-low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
apolipoprotein M
Names
NG20-like protein
alternative name: G3a, NG20
protein G3a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256169.2NP_001243098.1  apolipoprotein M isoform 2

    See identical proteins and their annotated locations for NP_001243098.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA476324, AL662801, CB054016, CN428415
    Consensus CDS
    CCDS59004.1
    UniProtKB/Swiss-Prot
    O95445
    UniProtKB/TrEMBL
    A0A1U9X793
    Related
    ENSP00000365085.4, ENST00000375920.8
    Conserved Domains (1) summary
    cl21528
    Location:1115
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
  2. NM_019101.3NP_061974.2  apolipoprotein M isoform 1

    See identical proteins and their annotated locations for NP_061974.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL662801
    Consensus CDS
    CCDS4710.1
    UniProtKB/Swiss-Prot
    O95445
    Related
    ENSP00000365081.3, ENST00000375916.4
    Conserved Domains (1) summary
    cl21528
    Location:1187
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RNA

  1. NR_045828.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, found in variant 1.
    Source sequence(s)
    AA846749, AL662801, BF344944, CB054016

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    31652404..31658210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715150.3XP_006715213.1  apolipoprotein M isoform X1

    See identical proteins and their annotated locations for XP_006715213.1

    Conserved Domains (1) summary
    cl21528
    Location:59155
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    3129694..3135499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    2900175..2905981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    2957450..2963256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    2994276..3000082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    2908223..2914028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    2951682..2957487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center