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lrrk2 leucine-rich repeat kinase 2 [ Danio rerio (zebrafish) ]

Gene ID: 559366, updated on 9-Sep-2025
Official Symbol
lrrk2provided by ZNC
Official Full Name
leucine-rich repeat kinase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-071218-6
See related
Ensembl:ENSDARG00000006169 AllianceGenome:ZFIN:ZDB-GENE-071218-6
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable ATP binding activity; GTP binding activity; and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Is expressed in gut; heart; muscle; nervous system; and pleuroperitoneal region. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See lrrk2 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
54
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 25 NC_133200.1 (38185085..38247220, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 25 NC_007136.7 (35603107..35664833, complement)

Chromosome 25 - NC_133200.1Genomic Context describing neighboring genes Neighboring gene Spi-1 proto-oncogene a Neighboring gene caseinolytic mitochondrial matrix peptidase chaperone subunit Xb Neighboring gene solute carrier family 2 member 13b Neighboring gene kinesin family member 21A

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Disruption of LRRK2 in Zebrafish leads to hyperactivity and weakened antibacterial response. Sheng D, et al. Biochem Biophys Res Commun, 2018 Mar 18. PMID 29499195
  2. Leucine-Rich Repeat Kinase-2 Controls the Differentiation and Maturation of Oligodendrocytes in Mice and Zebrafish. Filippini A, et al. Biomolecules, 2024 Jul 19. PMID 39062584, Free PMC Article
  3. LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation. Prabhudesai S, et al. J Neurosci Res, 2016 Aug. PMID 27265751
  4. Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect. Sheng D, et al. PLoS Genet, 2010 Apr 22. PMID 20421934, Free PMC Article
  5. Disruption of LRRK2 does not cause specific loss of dopaminergic neurons in zebrafish. Ren G, et al. PLoS One, 2011. PMID 21698186, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain.
    Title: Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain.
  2. Lrrk2 modulation of Wnt signaling during zebrafish development.
    Title: Lrrk2 modulation of Wnt signaling during zebrafish development.
  3. Inhibition of Lrrk2 reduces ethanol preference in a model of acute exposure in zebrafish.
    Title: Inhibition of Lrrk2 reduces ethanol preference in a model of acute exposure in zebrafish.
  4. disrupted LRRK2 in zebrafish and found hyperactivity rather than hypoactivity in adult zebrafish mutants
    Title: Disruption of LRRK2 in Zebrafish leads to hyperactivity and weakened antibacterial response.
  5. LRRK2 has multifaceted roles in zebrafish and that zebrafish represent a complementary model to further our understanding of this central protein
    Title: LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation.
  6. our similar early study and recent confirming experiments using the same reagents reported by Sheng et al. failed to reproduce the phenotype of the loss of dopaminergic neurons, although the mRNA of LRRK2 was molecularly disrupted
    Title: Disruption of LRRK2 does not cause specific loss of dopaminergic neurons in zebrafish.
  7. results demonstrate that zLRRK2 is an ortholog of hLRRK2 and that the deletion of WD40 domain of zLRRK2 provides a disease model for PD
    Title: Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
leucine-rich repeat serine/threonine-protein kinase 2
NP_001188385.2
XP_009296472.2
XP_068073486.1
XP_068073487.1
XP_073798207.1
XP_073798208.1
XP_073798209.1
XP_073798210.1
XP_073798211.1
XP_073798212.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201456.3 → NP_001188385.2  leucine-rich repeat serine/threonine-protein kinase 2

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000025
    UniProtKB/TrEMBL
    A0A8M1P3G6, A0AB32TDP8
    Related
    ENSDARP00000123741.1, ENSDART00000148718.3
    Conserved Domains (7) summary
    smart00220
    Location:1895 → 2142
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG4886
    Location:987 → 1290
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:1003 → 1275
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:1029 → 1052
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16095
    Location:1538 → 1750
    COR; C-terminal of Roc, COR, domain
    cl21453
    Location:1894 → 2149
    PKc_like; Protein Kinases, catalytic domain
    cl21455
    Location:1350 → 1518
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133200.1 Reference GRCz12tu Primary Assembly

    Range
    38185085..38247220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073942109.1 → XP_073798210.1  leucine-rich repeat serine/threonine-protein kinase 2 isoform X7

    UniProtKB/TrEMBL
    A0AB32TDP8

  2. XM_073942108.1 → XP_073798209.1  leucine-rich repeat serine/threonine-protein kinase 2 isoform X6

    UniProtKB/TrEMBL
    A0AB32TDP8

  3. XM_068217386.2 → XP_068073487.1  leucine-rich repeat serine/threonine-protein kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0AB32TDP8, A0AB32THR8

  4. XM_073942107.1 → XP_073798208.1  leucine-rich repeat serine/threonine-protein kinase 2 isoform X5

    UniProtKB/TrEMBL
    A0AB32TDP8

  5. XM_073942111.1 → XP_073798212.1  leucine-rich repeat serine/threonine-protein kinase 2 isoform X9

  6. XM_009298197.5 → XP_009296472.2  leucine-rich repeat serine/threonine-protein kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B7E3, A0AB32TDP8

  7. XM_068217385.2 → XP_068073486.1  leucine-rich repeat serine/threonine-protein kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0AB32TDP8, A0AB32TF89

  8. XM_073942106.1 → XP_073798207.1  leucine-rich repeat serine/threonine-protein kinase 2 isoform X4

  9. XM_073942110.1 → XP_073798211.1  leucine-rich repeat serine/threonine-protein kinase 2 isoform X8

RNA

  1. XR_012399907.1 RNA Sequence

  2. XR_012399906.1 RNA Sequence

  3. XR_012399904.1 RNA Sequence

  4. XR_012399905.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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