Ctps2 cytidine 5'-triphosphate synthase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctps2provided by MGI
Official Full Name: cytidine 5'-triphosphate synthase 2provided by MGI
Primary source: MGI:MGI:1933185
See related: Ensembl:ENSMUSG00000031360 AllianceGenome:MGI:1933185
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ctpsh; A830031M15Rik
Summary: Predicted to enable CTP synthase activity and identical protein binding activity. Predicted to be involved in CTP biosynthetic process and pyrimidine nucleobase biosynthetic process. Predicted to act upstream of or within glutamine metabolic process and pyrimidine nucleotide biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human CTPS2 (CTP synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 5.8), cerebellum adult (RPKM 5.0) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: X; X F4

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (161684264..161817537)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (162901268..163034541)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (2)
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha3079 (e-PCR)
- UniSTS:515639

AI326475 (e-PCR)
- UniSTS:186189

AU042539 (e-PCR)
- UniSTS:181350

AF028071 (e-PCR)
- UniSTS:160904

NoName (e-PCR)
- UniSTS:225192

DXMit182 (e-PCR), detects polymorphism
- UniSTS:132073

Homology

Homologs of the Ctps2 gene: The Ctps2 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.
Orthologs from Annotation Pipeline: 326 organisms have orthologs with human gene Ctps2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CTP synthase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within glutamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within pyrimidine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoophidium	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: CTP synthase 2

Names: CTP synthetase 2; CTP synthetase homolog; UTP--ammonia ligase 2; cytidine triphosphate synthase II

NP_001162040.1

EC 6.3.4.2

NP_001162041.1

EC 6.3.4.2

NP_001162043.1

EC 6.3.4.2

NP_001345327.1

EC 6.3.4.2

NP_061207.1

EC 6.3.4.2

XP_006528975.1

EC 6.3.4.2

XP_006528976.1

EC 6.3.4.2

XP_006528978.1

EC 6.3.4.2

XP_030107269.1

EC 6.3.4.2

XP_030107270.1

EC 6.3.4.2

XP_036017926.1

EC 6.3.4.2

XP_036017927.1

EC 6.3.4.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.