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dnm2a dynamin 2a [ Danio rerio (zebrafish) ]

Gene ID: 559334, updated on 9-Sep-2025
Official Symbol
dnm2aprovided by ZNC
Official Full Name
dynamin 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050913-84
See related
Ensembl:ENSDARG00000069937 AllianceGenome:ZFIN:ZDB-GENE-050913-84
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dnm2; zgc:114072
Summary
Predicted to enable GTPase activity and microtubule binding activity. Acts upstream of or within several processes, including chordate embryonic development; convergent extension; and somite development. Predicted to be active in several cellular components, including microtubule; plasma membrane; and synapse. Is expressed in several structures, including central nervous system; liver; otic vesicle; paraxial mesoderm; and pericardial region. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (dynamin 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See dnm2a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 3 NC_133178.1 (48208909..48299799)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 3 NC_007114.7 (47130836..47221386)

Chromosome 3 - NC_133178.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101883904 Neighboring gene queuine tRNA-ribosyltransferase 1 Neighboring gene microRNA 199-2a Neighboring gene transmembrane p24 trafficking protein 1a Neighboring gene TNF superfamily member 14a

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. The myopathy-causing mutation DNM2-S619L leads to defective tubulation in vitro and in developing zebrafish. Gibbs EM, et al. Dis Model Mech, 2014 Jan. PMID 24135484, Free PMC Article
  2. Dynamin-2 mediates heart failure by modulating Ca2+ -dependent cardiomyocyte apoptosis. Li J, et al. Int J Cardiol, 2013 Oct 3. PMID 23410488
  3. Zebrafish as a Model to Investigate Dynamin 2-Related Diseases. Bragato C, et al. Sci Rep, 2016 Feb 4. PMID 26842864, Free PMC Article
  4. Two dynamin-2 genes are required for normal zebrafish development. Gibbs EM, et al. PLoS One, 2013. PMID 23418470, Free PMC Article
  5. Synaptic vesicles are "primed" for fast clathrin-mediated endocytosis at the ribbon synapse. Pelassa I, et al. Front Mol Neurosci, 2014. PMID 25520613, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data confirm that the zebrafish dnm2a knockdown is a valuable model for dynaminopathies.
    Title: Zebrafish as a Model to Investigate Dynamin 2-Related Diseases.
  2. DNM2-S619L causes disease, in part, by interfering with membrane tubulation
    Title: The myopathy-causing mutation DNM2-S619L leads to defective tubulation in vitro and in developing zebrafish.
  3. Our findings suggest that dnm2 and dnm2-like are orthologs to human DNM2, and that they are required for normal zebrafish development.
    Title: Two dynamin-2 genes are required for normal zebrafish development.
Submit: New GeneRIF Correction

Homology

Clone Names

  • MGC114072

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within convergent extension IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within convergent extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle structure development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within somite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic cup IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in podosome IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in uropod IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
dynamin-2
Names
dynamin 2
NP_001025299.1
XP_005164298.1
XP_005164300.1
XP_021326549.1
XP_021326550.1
XP_021326556.1
XP_021326558.1
XP_068073278.1
XP_068073280.1
XP_068073285.1
XP_068073289.1
XP_068073291.1
XP_068073294.1
XP_068073302.1
XP_068073307.1
XP_073798027.1
XP_073798029.1
XP_073798038.1
XP_073798049.1
XP_073798056.1
XP_073798065.1
XP_073798069.1
XP_073798080.1
XP_073798092.1
XP_073798095.1
XP_073798103.1
XP_073798104.1
XP_073798106.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030128.1 → NP_001025299.1  dynamin-2

    See identical proteins and their annotated locations for NP_001025299.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097134
    UniProtKB/TrEMBL
    A0A8M1N774, Q4V8Z7
    Related
    ENSDARP00000025652.9, ENSDART00000024031.11
    Conserved Domains (6) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    COG0699
    Location:79 → 500
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:513 → 623
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam00169
    Location:515 → 617
    PH; PH domain
    pfam01031
    Location:217 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:645 → 733
    GED; Dynamin GTPase effector domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133178.1 Reference GRCz12tu Primary Assembly

    Range
    48208909..48299799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073941991.1 → XP_073798092.1  dynamin-2 isoform X21

  2. XM_073941979.1 → XP_073798080.1  dynamin-2 isoform X20

    UniProtKB/TrEMBL
    A0AB32TIH4

  3. XM_068217201.2 → XP_068073302.1  dynamin-2 isoform X20

    UniProtKB/TrEMBL
    A0AB32TIH4

  4. XM_073941968.1 → XP_073798069.1  dynamin-2 isoform X15

  5. XM_073941994.1 → XP_073798095.1  dynamin-2 isoform X22

    UniProtKB/TrEMBL
    A0AB32TH80

  6. XM_068217206.2 → XP_068073307.1  dynamin-2 isoform X22

    UniProtKB/TrEMBL
    A0AB32TH80

  7. XM_073942002.1 → XP_073798103.1  dynamin-2 isoform X23

  8. XM_068217179.2 → XP_068073280.1  dynamin-2 isoform X2

    UniProtKB/TrEMBL
    A0AB32TE56

  9. XM_021470874.3 → XP_021326549.1  dynamin-2 isoform X7

    UniProtKB/TrEMBL
    A0A8M9PNW1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:537 → 645
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 498
    Dynamin_M; Dynamin central region
    pfam02212
    Location:667 → 755
    GED; Dynamin GTPase effector domain
    cl26464
    Location:757 → 875
    Atrophin-1; Atrophin-1 family

  10. XM_068217177.2 → XP_068073278.1  dynamin-2 isoform X1

    UniProtKB/TrEMBL
    A0AB32TD14

  11. XM_068217184.2 → XP_068073285.1  dynamin-2 isoform X3

    UniProtKB/TrEMBL
    A0AB32TIR1

  12. XM_021470875.3 → XP_021326550.1  dynamin-2 isoform X10

    UniProtKB/TrEMBL
    A0A8M9PZL4
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:531 → 641
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 498
    Dynamin_M; Dynamin central region
    pfam02212
    Location:663 → 751
    GED; Dynamin GTPase effector domain
    cl26464
    Location:753 → 871
    Atrophin-1; Atrophin-1 family

  13. XM_068217188.2 → XP_068073289.1  dynamin-2 isoform X8

    UniProtKB/TrEMBL
    A0AB32TBP4

  14. XM_005164241.6 → XP_005164298.1  dynamin-2 isoform X16

    UniProtKB/TrEMBL
    A0A0R4IIR1, A0A8M2BBQ8
    Related
    ENSDARP00000134807.1
    Conserved Domains (7) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    COG0699
    Location:79 → 500
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:519 → 627
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam00169
    Location:519 → 621
    PH; PH domain
    pfam01031
    Location:217 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:649 → 737
    GED; Dynamin GTPase effector domain
    pfam17093
    Location:796 → 848
    PBP_N; Penicillin-binding protein N-terminus

  15. XM_073941928.1 → XP_073798029.1  dynamin-2 isoform X5

  16. XM_073941955.1 → XP_073798056.1  dynamin-2 isoform X13

  17. XM_068217193.2 → XP_068073294.1  dynamin-2 isoform X11

    UniProtKB/TrEMBL
    A0AB32TD82

  18. XM_005164243.6 → XP_005164300.1  dynamin-2 isoform X18

    See identical proteins and their annotated locations for XP_005164300.1

    UniProtKB/TrEMBL
    A0A8M2BBJ5, T1SXK0
    Related
    ENSDARP00000135475.1
    Conserved Domains (7) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    COG0699
    Location:79 → 500
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:513 → 623
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam00169
    Location:515 → 617
    PH; PH domain
    pfam01031
    Location:217 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:645 → 733
    GED; Dynamin GTPase effector domain
    pfam17093
    Location:792 → 844
    PBP_N; Penicillin-binding protein N-terminus

  19. XM_073941926.1 → XP_073798027.1  dynamin-2 isoform X4

  20. XM_068217190.2 → XP_068073291.1  dynamin-2 isoform X9

    UniProtKB/TrEMBL
    A0AB32TEM8

  21. XM_021470881.3 → XP_021326556.1  dynamin-2 isoform X17

    UniProtKB/TrEMBL
    A0A8M9PW32
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:519 → 627
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 501
    Dynamin_M; Dynamin central region
    pfam02212
    Location:649 → 737
    GED; Dynamin GTPase effector domain
    cl26464
    Location:739 → 857
    Atrophin-1; Atrophin-1 family

  22. XM_073941937.1 → XP_073798038.1  dynamin-2 isoform X6

  23. XM_073941964.1 → XP_073798065.1  dynamin-2 isoform X14

  24. XM_073941948.1 → XP_073798049.1  dynamin-2 isoform X12

  25. XM_021470883.3 → XP_021326558.1  dynamin-2 isoform X19

    UniProtKB/TrEMBL
    A0A8M9PHU4
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:513 → 623
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 501
    Dynamin_M; Dynamin central region
    pfam02212
    Location:645 → 733
    GED; Dynamin GTPase effector domain
    cl26464
    Location:735 → 853
    Atrophin-1; Atrophin-1 family

  26. XM_073942003.1 → XP_073798104.1  dynamin-2 isoform X24

  27. XM_073942005.1 → XP_073798106.1  dynamin-2 isoform X25

RNA

  1. XR_012399860.1 RNA Sequence

  2. XR_012399858.1 RNA Sequence

  3. XR_012399857.1 RNA Sequence

  4. XR_012399856.1 RNA Sequence

  5. XR_012399837.1 RNA Sequence

  6. XR_012399864.1 RNA Sequence

  7. XR_012399868.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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