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MYO5C myosin VC [ Homo sapiens (human) ]

Gene ID: 55930, updated on 4-Jul-2021

Summary

Official Symbol
MYO5Cprovided by HGNC
Official Full Name
myosin VCprovided by HGNC
Primary source
HGNC:HGNC:7604
See related
Ensembl:ENSG00000128833 MIM:610022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in thyroid (RPKM 12.9), stomach (RPKM 10.0) and 23 other tissues See more
Orthologs
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Genomic context

See MYO5C in Genome Data Viewer
Location:
15q21.2
Exon count:
41
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (52192318..52295804, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (52484519..52588001, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene BCL2 like 10 Neighboring gene G protein subunit beta 5 Neighboring gene competing endogenous lncRNA 1 for miR-4707-5p and miR-4767 Neighboring gene uncharacterized LOC105370820 Neighboring gene uncharacterized LOC105370819 Neighboring gene microRNA 1266 Neighboring gene myosin VA Neighboring gene negCOR silencer S8 Neighboring gene eukaryotic translation elongation factor 1 beta 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC74969

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle transport along actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-Vc
Names
myosin 5C
myosin-Vc

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018728.4NP_061198.2  unconventional myosin-Vc

    See identical proteins and their annotated locations for NP_061198.2

    Status: VALIDATED

    Source sequence(s)
    AC010674
    Consensus CDS
    CCDS42036.1
    UniProtKB/Swiss-Prot
    Q9NQX4
    Related
    ENSP00000261839.7, ENST00000261839.12
    Conserved Domains (11) summary
    smart00015
    Location:810828
    IQ; Calmodulin-binding motif
    smart00242
    Location:62752
    MYSc; Myosin. Large ATPases
    COG1340
    Location:8901150
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd15476
    Location:13691736
    Myo5c_CBD; Cargo binding domain of myosin 5C
    cd01380
    Location:81741
    MYSc_Myo5; class V myosin, motor domain
    pfam02736
    Location:1248
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam09311
    Location:10201345
    Rab5-bind; Rabaptin-like protein
    cd16269
    Location:9971010
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:9271030
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:9101163
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl23748
    Location:11601326
    DUF3585; Protein of unknown function (DUF3585)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    52192318..52295804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022408.2XP_016877897.1  unconventional myosin-Vc isoform X2

  2. XM_011521781.3XP_011520083.1  unconventional myosin-Vc isoform X1

    Conserved Domains (10) summary
    smart00242
    Location:62752
    MYSc; Myosin. Large ATPases
    COG1340
    Location:8621122
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd15476
    Location:13411708
    Myo5c_CBD; Cargo binding domain of myosin 5C
    cd01380
    Location:81741
    MYSc_Myo5; class V myosin, motor domain
    pfam02736
    Location:1248
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam09311
    Location:9921317
    Rab5-bind; Rabaptin-like protein
    cd16269
    Location:969982
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:8991002
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:8821135
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl23748
    Location:11321298
    DUF3585; Protein of unknown function (DUF3585)
  3. XM_017022410.2XP_016877899.1  unconventional myosin-Vc isoform X4

  4. XM_017022409.2XP_016877898.1  unconventional myosin-Vc isoform X3

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