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ep300a EP300 lysine acetyltransferase a [ Danio rerio (zebrafish) ]

Gene ID: 559273, updated on 5-Jul-2025
Official Symbol
ep300aprovided by ZNC
Official Full Name
EP300 lysine acetyltransferase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080403-16
See related
Ensembl:ENSDARG00000100666 AllianceGenome:ZFIN:ZDB-GENE-080403-16
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7158255; gb:dq017643
Summary
Enables histone acetyltransferase activity. Acts upstream of or within embryonic cranial skeleton morphogenesis; heart looping; and pectoral fin development. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of histone acetyltransferase complex and transcription regulator complex. Is expressed in blastoderm; blastomere; brain; digestive system; and heart. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; congestive heart failure; and idiopathic pulmonary fibrosis. Orthologous to human EP300 (E1A binding protein p300). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See ep300a in Genome Data Viewer
Location:
chromosome: 12
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 12 NC_133187.1 (20571872..20606675, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 12 NC_007123.7 (18927816..18961487, complement)

Chromosome 12 - NC_133187.1Genomic Context describing neighboring genes Neighboring gene desumoylating isopeptidase 1b Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 6 Neighboring gene Josephin domain containing 1 Neighboring gene chromobox homolog 7b Neighboring gene transfer RNA glutamine (anticodon CUG) Neighboring gene L3MBTL histone methyl-lysine binding protein 2 Neighboring gene chondroadherin-like b

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. A comparative expression analysis of gene transcripts in brain tissue of non-transgenic and GH-transgenic zebrafish (Danio rerio) using a DDRT-PCR approach. Alves-Costa FA, et al. An Acad Bras Cienc, 2012 Jun. PMID 22584411
  2. Directional divergence of Ep300 duplicates in teleosts and its implications. Wang X, et al. BMC Evol Biol, 2020 Oct 31. PMID 33129255, Free PMC Article
  3. Identification of de novo EP300 and PLAU variants in a patient with Rubinstein-Taybi syndrome-related arterial vasculopathy and skeletal anomaly. Park JE, et al. Sci Rep, 2021 Aug 5. PMID 34354133, Free PMC Article
  4. Histone acetyltransferase EP300 regulates the proliferation and differentiation of neural stem cells during adult neurogenesis and regenerative neurogenesis in the zebrafish optic tectum. Shimizu Y, et al. Neurosci Lett, 2021 Jun 21. PMID 34023416
  5. Expression Levels of SMAD Specific E3 Ubiquitin Protein Ligase 2 (Smurf2) and its Interacting Partners Show Region-specific Alterations During Brain Aging. Sasik MUT, et al. Neuroscience, 2020 Jun 1. PMID 32278060

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pectoral fin development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pectoral fin development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear lumen IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
histone acetyltransferase p300
Names
E1A binding protein p300 a
EP300b1
EP300b2
P300-A
XP_009304968.2
XP_009304969.2
XP_009304970.2
XP_009304971.2
XP_009304973.2
XP_021335970.2
XP_068080853.2
XP_068080854.2
XP_073774455.1
XP_073774456.1
XP_073774457.1
XP_073774458.1
XP_073774459.1
XP_073774460.1
XP_073774461.1
XP_073774462.1
XP_073774463.1
XP_073774465.1
XP_073774466.1
XP_073774467.1
XP_073774468.1
XP_073774469.1
XP_073774470.1
XP_073774471.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133187.1 Reference GRCz12tu Primary Assembly

    Range
    20571872..20606675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073918370.1 → XP_073774471.1  histone acetyltransferase p300 isoform X24

    UniProtKB/TrEMBL
    A0AB32TYF2

  2. XM_073918356.1 → XP_073774457.1  histone acetyltransferase p300 isoform X7

    UniProtKB/TrEMBL
    A0A8M3AYD6

  3. XM_073918369.1 → XP_073774470.1  histone acetyltransferase p300 isoform X22

    UniProtKB/TrEMBL
    A0AB32TYF2

  4. XM_073918365.1 → XP_073774466.1  histone acetyltransferase p300 isoform X17

    UniProtKB/TrEMBL
    A0A8M3B4N4

  5. XM_073918362.1 → XP_073774463.1  histone acetyltransferase p300 isoform X15

    UniProtKB/TrEMBL
    A0A8M3B7G7

  6. XM_073918354.1 → XP_073774455.1  histone acetyltransferase p300 isoform X5

    UniProtKB/TrEMBL
    A0A8M3AYD6

  7. XM_073918357.1 → XP_073774458.1  histone acetyltransferase p300 isoform X10

    UniProtKB/TrEMBL
    A0A8M3B7G7

  8. XM_021480295.3 → XP_021335970.2  histone acetyltransferase p300 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PYD9, A0A8M9QMW4

  9. XM_068224753.2 → XP_068080854.2  histone acetyltransferase p300 isoform X23

    UniProtKB/TrEMBL
    A0AB32TYF2

  10. XM_073918366.1 → XP_073774467.1  histone acetyltransferase p300 isoform X18

    UniProtKB/TrEMBL
    A0A8M3B4N4

  11. XM_073918364.1 → XP_073774465.1  histone acetyltransferase p300 isoform X16

    UniProtKB/TrEMBL
    A0A8M3B7G7

  12. XM_073918355.1 → XP_073774456.1  histone acetyltransferase p300 isoform X6

    UniProtKB/TrEMBL
    A0A8M3AYD6

  13. XM_073918368.1 → XP_073774469.1  histone acetyltransferase p300 isoform X21

    UniProtKB/TrEMBL
    A0A8M9PYE4, A0AB32TYF2

  14. XM_073918361.1 → XP_073774462.1  histone acetyltransferase p300 isoform X14

    UniProtKB/TrEMBL
    A0A8M3B4N4

  15. XM_073918359.1 → XP_073774460.1  histone acetyltransferase p300 isoform X12

    UniProtKB/TrEMBL
    A0A8M3B7G7

  16. XM_009306694.5 → XP_009304969.2  histone acetyltransferase p300 isoform X4

    UniProtKB/TrEMBL
    A0A8M3AYD6, A0A8M9Q9D0

  17. XM_073918367.1 → XP_073774468.1  histone acetyltransferase p300 isoform X20

    UniProtKB/TrEMBL
    A0A8M3BE74

  18. XM_073918360.1 → XP_073774461.1  histone acetyltransferase p300 isoform X13

    UniProtKB/TrEMBL
    A0A8M3B4N4

  19. XM_073918358.1 → XP_073774459.1  histone acetyltransferase p300 isoform X11

    UniProtKB/TrEMBL
    A0A8M3B7G7

  20. XM_068224752.2 → XP_068080853.2  histone acetyltransferase p300 isoform X3

    UniProtKB/TrEMBL
    A0AB32TYG8

  21. XM_009306698.5 → XP_009304973.2  histone acetyltransferase p300 isoform X19

    UniProtKB/TrEMBL
    A0A8M3BE74, A0A8M9PSB9

  22. XM_009306696.5 → XP_009304971.2  histone acetyltransferase p300 isoform X9

    UniProtKB/TrEMBL
    A0A8M3B4N4, A0A8M9PFF3

  23. XM_009306695.5 → XP_009304970.2  histone acetyltransferase p300 isoform X8

    UniProtKB/TrEMBL
    A0A8M3B7G7, A0A8M9Q4R2

  24. XM_009306693.5 → XP_009304968.2  histone acetyltransferase p300 isoform X1

    UniProtKB/TrEMBL
    A0A8M3BE71, A0A8M9PFE9
Nucleotide Protein Strain
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