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ep300a EP300 lysine acetyltransferase a [ Danio rerio (zebrafish) ]

Gene ID: 559273, updated on 5-Jul-2025
Official Symbol
ep300aprovided by ZNC
Official Full Name
EP300 lysine acetyltransferase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080403-16
See related
Ensembl:ENSDARG00000100666 AllianceGenome:ZFIN:ZDB-GENE-080403-16
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7158255; gb:dq017643
Summary
Enables histone acetyltransferase activity. Acts upstream of or within embryonic cranial skeleton morphogenesis; heart looping; and pectoral fin development. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of histone acetyltransferase complex and transcription regulator complex. Is expressed in blastoderm; blastomere; brain; digestive system; and heart. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; congestive heart failure; and idiopathic pulmonary fibrosis. Orthologous to human EP300 (E1A binding protein p300). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See ep300a in Genome Data Viewer
Location:
chromosome: 12
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 12 NC_133187.1 (20571872..20606675, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 12 NC_007123.7 (18927816..18961487, complement)

Chromosome 12 - NC_133187.1Genomic Context describing neighboring genes Neighboring gene desumoylating isopeptidase 1b Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 6 Neighboring gene Josephin domain containing 1 Neighboring gene chromobox homolog 7b Neighboring gene transfer RNA glutamine (anticodon CUG) Neighboring gene L3MBTL histone methyl-lysine binding protein 2 Neighboring gene chondroadherin-like b

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear lumen IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
histone acetyltransferase p300
Names
E1A binding protein p300 a
EP300b1
EP300b2
P300-A
XP_009304968.2
XP_009304969.2
XP_009304970.2
XP_009304971.2
XP_009304973.2
XP_021335970.2
XP_068080853.2
XP_068080854.2
XP_073774455.1
XP_073774456.1
XP_073774457.1
XP_073774458.1
XP_073774459.1
XP_073774460.1
XP_073774461.1
XP_073774462.1
XP_073774463.1
XP_073774465.1
XP_073774466.1
XP_073774467.1
XP_073774468.1
XP_073774469.1
XP_073774470.1
XP_073774471.1

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133187.1 Reference GRCz12tu Primary Assembly

    Range
    20571872..20606675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073918370.1XP_073774471.1  histone acetyltransferase p300 isoform X24

    UniProtKB/TrEMBL
    A0AB32TYF2
  2. XM_073918356.1XP_073774457.1  histone acetyltransferase p300 isoform X7

    UniProtKB/TrEMBL
    A0A8M3AYD6
  3. XM_073918369.1XP_073774470.1  histone acetyltransferase p300 isoform X22

    UniProtKB/TrEMBL
    A0AB32TYF2
  4. XM_073918365.1XP_073774466.1  histone acetyltransferase p300 isoform X17

    UniProtKB/TrEMBL
    A0A8M3B4N4
  5. XM_073918362.1XP_073774463.1  histone acetyltransferase p300 isoform X15

    UniProtKB/TrEMBL
    A0A8M3B7G7
  6. XM_073918354.1XP_073774455.1  histone acetyltransferase p300 isoform X5

    UniProtKB/TrEMBL
    A0A8M3AYD6
  7. XM_073918357.1XP_073774458.1  histone acetyltransferase p300 isoform X10

    UniProtKB/TrEMBL
    A0A8M3B7G7
  8. XM_021480295.3XP_021335970.2  histone acetyltransferase p300 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PYD9, A0A8M9QMW4
  9. XM_068224753.2XP_068080854.2  histone acetyltransferase p300 isoform X23

    UniProtKB/TrEMBL
    A0AB32TYF2
  10. XM_073918366.1XP_073774467.1  histone acetyltransferase p300 isoform X18

    UniProtKB/TrEMBL
    A0A8M3B4N4
  11. XM_073918364.1XP_073774465.1  histone acetyltransferase p300 isoform X16

    UniProtKB/TrEMBL
    A0A8M3B7G7
  12. XM_073918355.1XP_073774456.1  histone acetyltransferase p300 isoform X6

    UniProtKB/TrEMBL
    A0A8M3AYD6
  13. XM_073918368.1XP_073774469.1  histone acetyltransferase p300 isoform X21

    UniProtKB/TrEMBL
    A0A8M9PYE4, A0AB32TYF2
  14. XM_073918361.1XP_073774462.1  histone acetyltransferase p300 isoform X14

    UniProtKB/TrEMBL
    A0A8M3B4N4
  15. XM_073918359.1XP_073774460.1  histone acetyltransferase p300 isoform X12

    UniProtKB/TrEMBL
    A0A8M3B7G7
  16. XM_009306694.5XP_009304969.2  histone acetyltransferase p300 isoform X4

    UniProtKB/TrEMBL
    A0A8M3AYD6, A0A8M9Q9D0
  17. XM_073918367.1XP_073774468.1  histone acetyltransferase p300 isoform X20

    UniProtKB/TrEMBL
    A0A8M3BE74
  18. XM_073918360.1XP_073774461.1  histone acetyltransferase p300 isoform X13

    UniProtKB/TrEMBL
    A0A8M3B4N4
  19. XM_073918358.1XP_073774459.1  histone acetyltransferase p300 isoform X11

    UniProtKB/TrEMBL
    A0A8M3B7G7
  20. XM_068224752.2XP_068080853.2  histone acetyltransferase p300 isoform X3

    UniProtKB/TrEMBL
    A0AB32TYG8
  21. XM_009306698.5XP_009304973.2  histone acetyltransferase p300 isoform X19

    UniProtKB/TrEMBL
    A0A8M3BE74, A0A8M9PSB9
  22. XM_009306696.5XP_009304971.2  histone acetyltransferase p300 isoform X9

    UniProtKB/TrEMBL
    A0A8M3B4N4, A0A8M9PFF3
  23. XM_009306695.5XP_009304970.2  histone acetyltransferase p300 isoform X8

    UniProtKB/TrEMBL
    A0A8M3B7G7, A0A8M9Q4R2
  24. XM_009306693.5XP_009304968.2  histone acetyltransferase p300 isoform X1

    UniProtKB/TrEMBL
    A0A8M3BE71, A0A8M9PFE9