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ep300a E1A binding protein p300 a [ Danio rerio (zebrafish) ]

Gene ID: 559273, updated on 8-Mar-2023

Summary

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Official Symbol
ep300aprovided by ZNC
Official Full Name
E1A binding protein p300 aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080403-16
See related
Ensembl:ENSDARG00000100666 AllianceGenome:ZFIN:ZDB-GENE-080403-16
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7158255; gb:dq017643
Summary
Enables histone acetyltransferase activity. Acts upstream of or within embryonic cranial skeleton morphogenesis; heart looping; and pectoral fin development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of histone acetyltransferase complex and transcription regulator complex. Is expressed in blastoderm; blastomere; brain; intestinal bulb; and liver. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Orthologous to human EP300 (E1A binding protein p300). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ep300a in Genome Data Viewer
Location:
chromosome: 12
Exon count:
31
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (18927062..18961731, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (18805623..18839821, complement)
103 previous assembly Zv9 (GCF_000002035.4) 12 NC_007123.5 (20023344..20057979, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene Josephin domain containing 1 Neighboring gene chromobox homolog 7b Neighboring gene transfer RNA glutamine (anticodon CUG) Neighboring gene L3MBTL histone methyl-lysine binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Directional divergence of Ep300 duplicates in teleosts and its implications. Wang X, et al. BMC Evol Biol, 2020 Oct 31. PMID 33129255, Free PMC Article
  2. A comparative expression analysis of gene transcripts in brain tissue of non-transgenic and GH-transgenic zebrafish (Danio rerio) using a DDRT-PCR approach. Alves-Costa FA, et al. An Acad Bras Cienc, 2012 Jun. PMID 22584411
  3. Identification of de novo EP300 and PLAU variants in a patient with Rubinstein-Taybi syndrome-related arterial vasculopathy and skeletal anomaly. Park JE, et al. Sci Rep, 2021 Aug 5. PMID 34354133, Free PMC Article
  4. Histone acetyltransferase EP300 regulates the proliferation and differentiation of neural stem cells during adult neurogenesis and regenerative neurogenesis in the zebrafish optic tectum. Shimizu Y, et al. Neurosci Lett, 2021 Jun 21. PMID 34023416
  5. Expression Levels of SMAD Specific E3 Ubiquitin Protein Ligase 2 (Smurf2) and its Interacting Partners Show Region-specific Alterations During Brain Aging. Sasik MUT, et al. Neuroscience, 2020 Jun 1. PMID 32278060

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in histone acetylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within histone acetylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pectoral fin development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pectoral fin development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
histone acetyltransferase p300
Names
EP300b1
EP300b2
P300-A
XP_009304968.1
XP_009304969.1
XP_009304970.1
XP_009304971.1
XP_009304973.1
XP_009304974.1
XP_021328194.1
XP_021328195.1
XP_021328196.1
XP_021328197.1
XP_021329912.1
XP_021329913.1
XP_021329914.1
XP_021329915.1
XP_021329916.1
XP_021329917.1
XP_021329918.1
XP_021329919.1
XP_021335970.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    18927062..18961731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480295.1 → XP_021335970.1  histone acetyltransferase p300 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QMW4
    Conserved Domains (12) summary
    cd05495
    Location:1055 → 1162
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1753 → 1831
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1692 → 1732
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1174 → 1265
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1266 → 1300
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam02172
    Location:570 → 648
    KIX; KIX domain
    pfam02135
    Location:361 → 428
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1329 → 1636
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2173 → 2245
    Creb_binding; Creb binding
    pfam09606
    Location:1865 → 2157
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl25496
    Location:829 → 968
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl26464
    Location:669 → 962
    Atrophin-1; Atrophin-1 family

  2. XM_009306699.3 → XP_009304974.1  histone acetyltransferase p300 isoform X7

    UniProtKB/TrEMBL
    A0A8M3AYE1
    Conserved Domains (9) summary
    cd05495
    Location:1054 → 1161
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1733 → 1811
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1672 → 1712
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1173 → 1245
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1246 → 1280
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam02135
    Location:362 → 429
    zf-TAZ; TAZ zinc finger
    pfam02172
    Location:569 → 647
    KIX; KIX domain
    pfam08214
    Location:1309 → 1616
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2120 → 2225
    Creb_binding; Creb binding

  3. XM_009306694.3 → XP_009304969.1  histone acetyltransferase p300 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AYD6
    Related
    ENSDARP00000140048.1, ENSDART00000172574.2
    Conserved Domains (9) summary
    cd05495
    Location:1054 → 1161
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1752 → 1830
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1691 → 1731
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1173 → 1264
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1265 → 1299
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam02135
    Location:362 → 429
    zf-TAZ; TAZ zinc finger
    pfam02172
    Location:569 → 647
    KIX; KIX domain
    pfam08214
    Location:1328 → 1635
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2139 → 2244
    Creb_binding; Creb binding

  4. XM_009306698.3 → XP_009304973.1  histone acetyltransferase p300 isoform X6

    UniProtKB/TrEMBL
    A0A8M3BE74
    Conserved Domains (9) summary
    cd05495
    Location:1056 → 1163
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1735 → 1813
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1674 → 1714
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1175 → 1247
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1248 → 1282
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam02135
    Location:362 → 429
    zf-TAZ; TAZ zinc finger
    pfam02172
    Location:571 → 649
    KIX; KIX domain
    pfam08214
    Location:1311 → 1618
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2122 → 2227
    Creb_binding; Creb binding

  5. XM_009306696.3 → XP_009304971.1  histone acetyltransferase p300 isoform X5

    UniProtKB/TrEMBL
    A0A8M3B4N4
    Conserved Domains (9) summary
    cd05495
    Location:1056 → 1163
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1744 → 1822
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1683 → 1723
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1175 → 1256
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1257 → 1291
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam02135
    Location:362 → 429
    zf-TAZ; TAZ zinc finger
    pfam02172
    Location:571 → 649
    KIX; KIX domain
    pfam08214
    Location:1320 → 1627
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2131 → 2236
    Creb_binding; Creb binding

  6. XM_009306695.3 → XP_009304970.1  histone acetyltransferase p300 isoform X4

    UniProtKB/TrEMBL
    A0A8M3B7G7
    Related
    ENSDARP00000136270.1, ENSDART00000168405.2
    Conserved Domains (9) summary
    cd05495
    Location:1056 → 1163
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1745 → 1823
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1684 → 1724
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1175 → 1257
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1258 → 1292
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam02135
    Location:362 → 429
    zf-TAZ; TAZ zinc finger
    pfam02172
    Location:571 → 649
    KIX; KIX domain
    pfam08214
    Location:1321 → 1628
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2132 → 2237
    Creb_binding; Creb binding

  7. XM_009306693.3 → XP_009304968.1  histone acetyltransferase p300 isoform X1

    UniProtKB/TrEMBL
    A0A8M3BE71
    Conserved Domains (10) summary
    cd05495
    Location:1056 → 1163
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1754 → 1832
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1693 → 1733
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    pfam09606
    Location:439 → 907
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15802
    Location:1175 → 1266
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1267 → 1301
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam02135
    Location:362 → 429
    zf-TAZ; TAZ zinc finger
    pfam02172
    Location:571 → 649
    KIX; KIX domain
    pfam08214
    Location:1330 → 1637
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2141 → 2246
    Creb_binding; Creb binding

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394835.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    917741..937302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021472522.1 → XP_021328197.1  histone acetyltransferase p300 isoform X11

    UniProtKB/TrEMBL
    A0A8M9PAU5
    Conserved Domains (9) summary
    cd05495
    Location:349 → 456
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1028 → 1106
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:967 → 1007
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:468 → 540
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:541 → 575
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam08214
    Location:604 → 911
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1448 → 1520
    Creb_binding; Creb binding
    pfam09606
    Location:1140 → 1432
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl25496
    Location:123 → 262
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  2. XM_021472521.1 → XP_021328196.1  histone acetyltransferase p300 isoform X10

    UniProtKB/TrEMBL
    A0A8M9Q0N1
    Conserved Domains (9) summary
    cd05495
    Location:349 → 456
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1037 → 1115
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:976 → 1016
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:468 → 549
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:550 → 584
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam08214
    Location:613 → 920
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1457 → 1529
    Creb_binding; Creb binding
    pfam09606
    Location:1149 → 1441
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl25496
    Location:123 → 262
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  3. XM_021472520.1 → XP_021328195.1  histone acetyltransferase p300 isoform X9

    UniProtKB/TrEMBL
    A0A8M9Q3W4
    Conserved Domains (9) summary
    cd05495
    Location:349 → 456
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1038 → 1116
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:977 → 1017
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:468 → 550
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:551 → 585
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam08214
    Location:614 → 921
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1458 → 1530
    Creb_binding; Creb binding
    pfam09606
    Location:1150 → 1442
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl25496
    Location:123 → 262
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  4. XM_021472519.1 → XP_021328194.1  histone acetyltransferase p300 isoform X8

    UniProtKB/TrEMBL
    A0A8M9PTF6
    Conserved Domains (9) summary
    cd05495
    Location:349 → 456
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1047 → 1125
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:986 → 1026
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:468 → 559
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:560 → 594
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam08214
    Location:623 → 930
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1467 → 1539
    Creb_binding; Creb binding
    pfam09606
    Location:1159 → 1451
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl25496
    Location:123 → 262
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395301.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    142075..177911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474239.1 → XP_021329914.1  histone acetyltransferase p300 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PYD9
    Conserved Domains (12) summary
    cd05495
    Location:1057 → 1164
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1755 → 1833
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1694 → 1734
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1176 → 1267
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1268 → 1302
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam02172
    Location:572 → 650
    KIX; KIX domain
    pfam02135
    Location:363 → 430
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1331 → 1638
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2175 → 2247
    Creb_binding; Creb binding
    pfam09606
    Location:1867 → 2159
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl25496
    Location:831 → 962
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl28033
    Location:647 → 959
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  2. XM_021474238.1 → XP_021329913.1  histone acetyltransferase p300 isoform X12

    UniProtKB/TrEMBL
    A0A8M9PSB5
    Conserved Domains (11) summary
    cd05495
    Location:1057 → 1164
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1755 → 1833
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1694 → 1734
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1176 → 1267
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1268 → 1302
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam02172
    Location:573 → 651
    KIX; KIX domain
    pfam02135
    Location:364 → 431
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1331 → 1638
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2175 → 2247
    Creb_binding; Creb binding
    pfam09606
    Location:1867 → 2159
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam15316
    Location:873 → 965
    MDFI; MyoD family inhibitor

  3. XM_021474243.1 → XP_021329918.1  histone acetyltransferase p300 isoform X6

    UniProtKB/TrEMBL
    A0A8M9PSB9
    Conserved Domains (12) summary
    cd05495
    Location:1058 → 1165
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1737 → 1815
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1676 → 1716
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1177 → 1249
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1250 → 1284
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam02172
    Location:573 → 651
    KIX; KIX domain
    pfam02135
    Location:364 → 431
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1313 → 1620
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2157 → 2229
    Creb_binding; Creb binding
    pfam09606
    Location:1849 → 2141
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl25496
    Location:832 → 963
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl28033
    Location:648 → 960
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  4. XM_021474242.1 → XP_021329917.1  histone acetyltransferase p300 isoform X5

    UniProtKB/TrEMBL
    A0A8M9PFF3
    Conserved Domains (12) summary
    cd05495
    Location:1058 → 1165
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1746 → 1824
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1685 → 1725
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1177 → 1258
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1259 → 1293
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam02172
    Location:573 → 651
    KIX; KIX domain
    pfam02135
    Location:364 → 431
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1322 → 1629
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2166 → 2238
    Creb_binding; Creb binding
    pfam09606
    Location:1858 → 2150
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl25496
    Location:832 → 963
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl28033
    Location:648 → 960
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  5. XM_021474241.1 → XP_021329916.1  histone acetyltransferase p300 isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q4R2
    Conserved Domains (12) summary
    cd05495
    Location:1058 → 1165
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1747 → 1825
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1686 → 1726
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1177 → 1259
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1260 → 1294
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam02172
    Location:573 → 651
    KIX; KIX domain
    pfam02135
    Location:364 → 431
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1323 → 1630
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2167 → 2239
    Creb_binding; Creb binding
    pfam09606
    Location:1859 → 2151
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl25496
    Location:832 → 963
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl28033
    Location:648 → 960
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  6. XM_021474237.1 → XP_021329912.1  histone acetyltransferase p300 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PFE9
    Conserved Domains (12) summary
    cd05495
    Location:1058 → 1165
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1756 → 1834
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1695 → 1735
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1177 → 1268
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1269 → 1303
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam02172
    Location:573 → 651
    KIX; KIX domain
    pfam02135
    Location:364 → 431
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1332 → 1639
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2176 → 2248
    Creb_binding; Creb binding
    pfam09606
    Location:1868 → 2160
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl25496
    Location:832 → 963
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl28033
    Location:648 → 960
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  7. XM_021474244.1 → XP_021329919.1  histone acetyltransferase p300 isoform X7

    UniProtKB/TrEMBL
    A0A8M9PYE4
    Conserved Domains (12) summary
    cd05495
    Location:1056 → 1163
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1735 → 1813
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1674 → 1714
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1175 → 1247
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1248 → 1282
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam02172
    Location:571 → 649
    KIX; KIX domain
    pfam02135
    Location:364 → 431
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1311 → 1618
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2155 → 2227
    Creb_binding; Creb binding
    pfam09606
    Location:1847 → 2139
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl25496
    Location:830 → 961
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl28033
    Location:646 → 958
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  8. XM_021474240.1 → XP_021329915.1  histone acetyltransferase p300 isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q9D0
    Conserved Domains (12) summary
    cd05495
    Location:1056 → 1163
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1754 → 1832
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    cd02337
    Location:1693 → 1733
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1175 → 1266
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1267 → 1301
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam02172
    Location:571 → 649
    KIX; KIX domain
    pfam02135
    Location:364 → 431
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1330 → 1637
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2174 → 2246
    Creb_binding; Creb binding
    pfam09606
    Location:1866 → 2158
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl25496
    Location:830 → 961
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl28033
    Location:646 → 958
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
Nucleotide Protein Strain
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