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INKA2 inka box actin regulator 2 [ Homo sapiens (human) ]

Gene ID: 55924, updated on 23-Nov-2021

Summary

Official Symbol
INKA2provided by HGNC
Official Full Name
inka box actin regulator 2provided by HGNC
Primary source
HGNC:HGNC:28045
See related
Ensembl:ENSG00000197852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM212B; C1orf183
Expression
Ubiquitous expression in brain (RPKM 6.5), heart (RPKM 3.4) and 23 other tissues See more
Orthologs
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Genomic context

See INKA2 in Genome Data Viewer
Location:
1p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (111722064..111755797, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (112264686..112298419, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAP1A, member of RAS oncogene family Neighboring gene RNA, U6 small nuclear 151, pseudogene Neighboring gene keratin 18 pseudogene 57 Neighboring gene uncharacterized LOC101928718 Neighboring gene INKA2 antisense RNA 1 Neighboring gene DEAD-box helicase 20 Neighboring gene potassium voltage-gated channel subfamily D member 3 Neighboring gene KCND3 intronic transcript 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31105

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
PAK4-inhibitor INKA2
Names
HInca-r
family with sequence similarity 212 member B
induced in neural crest by AP2-alpha protein-related homolog
protein FAM212B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019099.5NP_061972.1  PAK4-inhibitor INKA2 isoform 1

    See identical proteins and their annotated locations for NP_061972.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL049557, DA306915
    Consensus CDS
    CCDS841.1
    UniProtKB/Swiss-Prot
    Q9NTI7
    Related
    ENSP00000349805.5, ENST00000357260.6
    Conserved Domains (1) summary
    pfam15342
    Location:136175
    FAM212; FAM212 family
  2. NM_198926.2NP_945120.1  PAK4-inhibitor INKA2 isoform 2

    See identical proteins and their annotated locations for NP_945120.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL049557, AL137199
    UniProtKB/Swiss-Prot
    Q9NTI7
    UniProtKB/TrEMBL
    A0A1W2PL72
    Conserved Domains (1) summary
    pfam15342
    Location:121160
    FAM212; FAM212 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    111722064..111755797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541783.2XP_011540085.1  PAK4-inhibitor INKA2 isoform X1

    See identical proteins and their annotated locations for XP_011540085.1

    Conserved Domains (1) summary
    pfam15342
    Location:99156
    FAM212; FAM212 family
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