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FAM212B family with sequence similarity 212 member B [ Homo sapiens (human) ]

Gene ID: 55924, updated on 5-Nov-2017
Official Symbol
FAM212Bprovided by HGNC
Official Full Name
family with sequence similarity 212 member Bprovided by HGNC
Primary source
HGNC:HGNC:28045
See related
Ensembl:ENSG00000197852 Vega:OTTHUMG00000011953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INKA2; C1orf183
Expression
Ubiquitous expression in brain (RPKM 6.5), heart (RPKM 3.4) and 23 other tissues See more
Orthologs
Location:
1p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (111722064..111755797, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (112264686..112298419, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAP1A, member of RAS oncogene family Neighboring gene RNA, U6 small nuclear 151, pseudogene Neighboring gene keratin 18 pseudogene 57 Neighboring gene uncharacterized LOC101928718 Neighboring gene FAM212B antisense RNA 1 Neighboring gene DEAD-box helicase 20 Neighboring gene potassium voltage-gated channel subfamily D member 3 Neighboring gene KCND3 intronic transcript 1 Neighboring gene KCND3 antisense RNA 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ31105

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
negative regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
PAK4-inhibitor INKA2; protein FAM212B
Names
HInca-r
induced in neural crest by AP2-alpha protein-related homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019099.4NP_061972.1  PAK4-inhibitor INKA2 isoform 1

    See identical proteins and their annotated locations for NP_061972.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL049557, DA306915
    Consensus CDS
    CCDS841.1
    UniProtKB/Swiss-Prot
    Q9NTI7
    Related
    ENSP00000349805.5, OTTHUMP00000013737, ENST00000357260.5, OTTHUMT00000033060
    Conserved Domains (1) summary
    pfam15342
    Location:136175
    FAM212; FAM212 family
  2. NM_198926.2NP_945120.1  PAK4-inhibitor INKA2 isoform 2

    See identical proteins and their annotated locations for NP_945120.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL049557, AL137199
    Consensus CDS
    CCDS44195.1
    UniProtKB/Swiss-Prot
    Q9NTI7
    UniProtKB/TrEMBL
    A0A1W2PL72
    Related
    ENSP00000408238.2, OTTHUMP00000231663, ENST00000444059.2, OTTHUMT00000387370
    Conserved Domains (1) summary
    pfam15342
    Location:121160
    FAM212; FAM212 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

    Range
    111722064..111755797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541783.2XP_011540085.1  protein FAM212B isoform X1

    See identical proteins and their annotated locations for XP_011540085.1

    Conserved Domains (1) summary
    pfam15342
    Location:117156
    FAM212; FAM212 family

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    112379672..112413403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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