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NXT2 nuclear transport factor 2 like export factor 2 [ Homo sapiens (human) ]

Gene ID: 55916, updated on 12-Oct-2019

Summary

Official Symbol
NXT2provided by HGNC
Official Full Name
nuclear transport factor 2 like export factor 2provided by HGNC
Primary source
HGNC:HGNC:18151
See related
Ensembl:ENSG00000101888 MIM:300320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P15-2
Summary
The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]
Expression
Broad expression in testis (RPKM 16.8), bone marrow (RPKM 5.3) and 23 other tissues See more
Orthologs

Genomic context

See NXT2 in Genome Data Viewer
Location:
Xq23
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (109535824..109544698)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (108779010..108787927)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 309, pseudogene Neighboring gene guanylate cyclase 2F, retinal Neighboring gene Sharpr-MPRA regulatory region 8383 Neighboring gene mitofusin-1-like Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Exon junction complex (EJC), organism-specific biosystem (from KEGG)
    Exon junction complex (EJC), organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • Exon junction complex (EJC), conserved biosystem (from KEGG)
    Exon junction complex (EJC), conserved biosystemStructural complex; Genetic information processing; RNA processing
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
nucleocytoplasmic transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
NTF2-related export protein 2
Names
protein p15-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029691.1 RefSeqGene

    Range
    5044..13918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242617.2NP_001229546.1  NTF2-related export protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001229546.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. This results in translation initiation from a downstream AUG, and an isoform (2, also known as p15-2a) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA806876, AF201942, BC014888, DA442845
    Consensus CDS
    CCDS56605.1
    UniProtKB/Swiss-Prot
    Q9NPJ8
    Related
    ENSP00000361178.1, ENST00000372106.5
    Conserved Domains (1) summary
    cd00780
    Location:13138
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
  2. NM_001242618.2NP_001229547.1  NTF2-related export protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001229547.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs at the 5' end compared to variant 1. This results in translation initiation from a downstream AUG, and an isoform (3, also known as p15-2b) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA806876, AJ278323, BC014888
    Consensus CDS
    CCDS56606.1
    UniProtKB/Swiss-Prot
    Q9NPJ8
    Related
    ENSP00000361175.1, ENST00000372103.1
    Conserved Domains (1) summary
    cd00780
    Location:1110
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
  3. NM_018698.5NP_061168.2  NTF2-related export protein 2 isoform 1

    See identical proteins and their annotated locations for NP_061168.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA806876, AK023289, BC014888
    Consensus CDS
    CCDS14546.1
    UniProtKB/Swiss-Prot
    Q9NPJ8
    Related
    ENSP00000218004.1, ENST00000218004.5
    Conserved Domains (1) summary
    cd00780
    Location:68193
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    109535824..109544698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530989.2XP_011529291.1  NTF2-related export protein 2 isoform X1

    Conserved Domains (1) summary
    cd00780
    Location:12137
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
  2. XM_017029648.2XP_016885137.1  NTF2-related export protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9NPJ8
    Conserved Domains (1) summary
    cd00780
    Location:1110
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
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