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ptprc protein tyrosine phosphatase receptor type C [ Danio rerio (zebrafish) ]

Gene ID: 559154, updated on 9-Sep-2025
Official Symbol
ptprcprovided by ZNC
Official Full Name
protein tyrosine phosphatase receptor type Cprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050208-585
See related
AllianceGenome:ZFIN:ZDB-GENE-050208-585
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:eu845; si:dkeyp-47c5.1
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to act upstream of or within protein dephosphorylation. Is expressed in common myeloid progenitor; epicardium; and hematopoietic system. Human ortholog(s) of this gene implicated in multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency 105. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See ptprc in Genome Data Viewer
Location:
chromosome: 22
Exon count:
64
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 22 NC_133197.1 (22814384..22897266, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 22 NC_007133.7 (22977257..23068394, complement)

Chromosome 22 - NC_133197.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488931 Neighboring gene uncharacterized LOC141380105 Neighboring gene microRNA 181a-1 Neighboring gene uncharacterized LOC141380327 Neighboring gene NIMA-related kinase 7 Neighboring gene LIM homeobox 9

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo. Bertrand JY, et al. Development, 2007 Dec. PMID 17959717, Free PMC Article
  2. Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis. Kulkeaw K, et al. Br J Haematol, 2018 Feb. PMID 29265183, Free PMC Article
  3. Haematopoietic stem cells derive directly from aortic endothelium during development. Bertrand JY, et al. Nature, 2010 Mar 4. PMID 20154733, Free PMC Article
  4. CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis. Bertrand JY, et al. Development, 2008 May. PMID 18417622, Free PMC Article
  5. The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1γ. Monteiro R, et al. EMBO J, 2011 Mar 16. PMID 21336259, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
receptor-type tyrosine-protein phosphatase C
Names
CD45 antigen
XP_073793929.1
XP_073793930.1
XP_073793931.1
XP_073793933.1
XP_073793934.1
XP_073793935.1
XP_073793936.1
XP_073793937.1
XP_073793938.1
XP_073793939.1
XP_073793940.1
XP_073793941.1
XP_073793942.1
XP_073793944.1
XP_073793945.1
XP_073793946.1
XP_073793947.1
XP_073793948.1
XP_073793949.1
XP_073793950.1
XP_073793951.1
XP_073793952.1
XP_073793953.1
XP_073793954.1
XP_073793955.1
XP_073793956.1
XP_073793957.1
XP_073793958.1
XP_073793959.1
XP_073793960.1
XP_073793961.1
XP_073793962.1
XP_073793963.1
XP_073793964.1
XP_073793965.1
XP_073793966.1
XP_073793967.1
XP_073793968.1
XP_073793969.1
XP_073793970.1
XP_073793971.1
XP_073793972.1
XP_073793973.1
XP_073793974.1
XP_073793975.1
XP_073793976.1
XP_073793977.1
XP_073793978.1
XP_073793979.1
XP_073793980.1

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133197.1 Reference GRCz12tu Primary Assembly

    Range
    22814384..22897266 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073937876.1 → XP_073793977.1  receptor-type tyrosine-protein phosphatase C isoform X47

  2. XM_073937875.1 → XP_073793976.1  receptor-type tyrosine-protein phosphatase C isoform X46

  3. XM_073937871.1 → XP_073793972.1  receptor-type tyrosine-protein phosphatase C isoform X42

  4. XM_073937870.1 → XP_073793971.1  receptor-type tyrosine-protein phosphatase C isoform X41

  5. XM_073937873.1 → XP_073793974.1  receptor-type tyrosine-protein phosphatase C isoform X44

  6. XM_073937872.1 → XP_073793973.1  receptor-type tyrosine-protein phosphatase C isoform X43

  7. XM_073937864.1 → XP_073793965.1  receptor-type tyrosine-protein phosphatase C isoform X35

  8. XM_073937863.1 → XP_073793964.1  receptor-type tyrosine-protein phosphatase C isoform X34

  9. XM_073937861.1 → XP_073793962.1  receptor-type tyrosine-protein phosphatase C isoform X32

  10. XM_073937860.1 → XP_073793961.1  receptor-type tyrosine-protein phosphatase C isoform X31

  11. XM_073937855.1 → XP_073793956.1  receptor-type tyrosine-protein phosphatase C isoform X26

  12. XM_073937854.1 → XP_073793955.1  receptor-type tyrosine-protein phosphatase C isoform X25

  13. XM_073937850.1 → XP_073793951.1  receptor-type tyrosine-protein phosphatase C isoform X21

  14. XM_073937849.1 → XP_073793950.1  receptor-type tyrosine-protein phosphatase C isoform X20

  15. XM_073937844.1 → XP_073793945.1  receptor-type tyrosine-protein phosphatase C isoform X15

  16. XM_073937843.1 → XP_073793944.1  receptor-type tyrosine-protein phosphatase C isoform X14

  17. XM_073937869.1 → XP_073793970.1  receptor-type tyrosine-protein phosphatase C isoform X40

  18. XM_073937859.1 → XP_073793960.1  receptor-type tyrosine-protein phosphatase C isoform X30

  19. XM_073937858.1 → XP_073793959.1  receptor-type tyrosine-protein phosphatase C isoform X29

  20. XM_073937853.1 → XP_073793954.1  receptor-type tyrosine-protein phosphatase C isoform X24

  21. XM_073937866.1 → XP_073793967.1  receptor-type tyrosine-protein phosphatase C isoform X37

  22. XM_073937865.1 → XP_073793966.1  receptor-type tyrosine-protein phosphatase C isoform X36

  23. XM_073937868.1 → XP_073793969.1  receptor-type tyrosine-protein phosphatase C isoform X39

  24. XM_073937867.1 → XP_073793968.1  receptor-type tyrosine-protein phosphatase C isoform X38

  25. XM_073937857.1 → XP_073793958.1  receptor-type tyrosine-protein phosphatase C isoform X28

  26. XM_073937856.1 → XP_073793957.1  receptor-type tyrosine-protein phosphatase C isoform X27

  27. XM_073937852.1 → XP_073793953.1  receptor-type tyrosine-protein phosphatase C isoform X23

  28. XM_073937851.1 → XP_073793952.1  receptor-type tyrosine-protein phosphatase C isoform X22

  29. XM_073937846.1 → XP_073793947.1  receptor-type tyrosine-protein phosphatase C isoform X17

  30. XM_073937845.1 → XP_073793946.1  receptor-type tyrosine-protein phosphatase C isoform X16

  31. XM_073937840.1 → XP_073793941.1  receptor-type tyrosine-protein phosphatase C isoform X12

  32. XM_073937839.1 → XP_073793940.1  receptor-type tyrosine-protein phosphatase C isoform X11

  33. XM_073937862.1 → XP_073793963.1  receptor-type tyrosine-protein phosphatase C isoform X33

  34. XM_073937848.1 → XP_073793949.1  receptor-type tyrosine-protein phosphatase C isoform X19

  35. XM_073937847.1 → XP_073793948.1  receptor-type tyrosine-protein phosphatase C isoform X18

  36. XM_073937841.1 → XP_073793942.1  receptor-type tyrosine-protein phosphatase C isoform X13

  37. XM_073937838.1 → XP_073793939.1  receptor-type tyrosine-protein phosphatase C isoform X10

  38. XM_073937835.1 → XP_073793936.1  receptor-type tyrosine-protein phosphatase C isoform X7

  39. XM_073937832.1 → XP_073793933.1  receptor-type tyrosine-protein phosphatase C isoform X4

  40. XM_073937837.1 → XP_073793938.1  receptor-type tyrosine-protein phosphatase C isoform X9

  41. XM_073937836.1 → XP_073793937.1  receptor-type tyrosine-protein phosphatase C isoform X8

  42. XM_073937834.1 → XP_073793935.1  receptor-type tyrosine-protein phosphatase C isoform X6

  43. XM_073937833.1 → XP_073793934.1  receptor-type tyrosine-protein phosphatase C isoform X5

  44. XM_073937830.1 → XP_073793931.1  receptor-type tyrosine-protein phosphatase C isoform X3

  45. XM_073937829.1 → XP_073793930.1  receptor-type tyrosine-protein phosphatase C isoform X2

  46. XM_073937828.1 → XP_073793929.1  receptor-type tyrosine-protein phosphatase C isoform X1

  47. XM_073937874.1 → XP_073793975.1  receptor-type tyrosine-protein phosphatase C isoform X45

  48. XM_073937878.1 → XP_073793979.1  receptor-type tyrosine-protein phosphatase C isoform X49

  49. XM_073937877.1 → XP_073793978.1  receptor-type tyrosine-protein phosphatase C isoform X48

  50. XM_073937879.1 → XP_073793980.1  receptor-type tyrosine-protein phosphatase C isoform X50

Nucleotide Protein Strain
Heading Accession and Version

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