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LANCL2 LanC like glutathione S-transferase 2 [ Homo sapiens (human) ]

Gene ID: 55915, updated on 4-Dec-2022

Summary

Official Symbol
LANCL2provided by HGNC
Official Full Name
LanC like glutathione S-transferase 2provided by HGNC
Primary source
HGNC:HGNC:6509
See related
Ensembl:ENSG00000132434 MIM:612919; AllianceGenome:HGNC:6509
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TASP; GPR69B
Summary
Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of abscisic acid-activated signaling pathway. Located in several cellular components, including cortical actin cytoskeleton; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 16.9), testis (RPKM 9.1) and 24 other tissues See more
Orthologs
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Genomic context

See LANCL2 in Genome Data Viewer
Location:
7p11.2
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (55365337..55433737)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (55525667..55594061)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (55433030..55501430)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene calmodulin 1 pseudogene 2 Neighboring gene RNA exonuclease 1 homolog Neighboring gene VOPP1 WW domain binding protein Neighboring gene Sharpr-MPRA regulatory region 1113 Neighboring gene VOPP1 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of LANCL2 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC87139

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
enables GTP binding NAS
Non-traceable Author Statement
more info
PubMed 
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-5-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lanC-like protein 2
Names
G protein-coupled receptor 69B
LanC (bacterial lantibiotic synthetase component C)-like 2
LanC lantibiotic synthetase component C-like 2
LanC like 2
testis-specific adriamycin sensitivity protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018697.4NP_061167.1  lanC-like protein 2

    See identical proteins and their annotated locations for NP_061167.1

    Status: VALIDATED

    Source sequence(s)
    AC073347
    Consensus CDS
    CCDS5517.1
    UniProtKB/Swiss-Prot
    Q9BSR1, Q9NS86
    UniProtKB/TrEMBL
    B3KTN5
    Related
    ENSP00000254770.2, ENST00000254770.3
    Conserved Domains (1) summary
    cd04794
    Location:103440
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    55365337..55433737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420614.1XP_047276570.1  lanC-like protein 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    55525667..55594061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)