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APOBR apolipoprotein B receptor [ Homo sapiens (human) ]

Gene ID: 55911, updated on 9-Aug-2020

Summary

Official Symbol
APOBRprovided by HGNC
Official Full Name
apolipoprotein B receptorprovided by HGNC
Primary source
HGNC:HGNC:24087
See related
Ensembl:ENSG00000184730 MIM:605220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APOB48R; APOB100R
Summary
Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon (RPKM 19.1), spleen (RPKM 14.5) and 12 other tissues See more
Orthologs

Genomic context

See APOBR in Genome Data Viewer
Location:
16p12.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (28494643..28498964)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28505970..28510291)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268171 Neighboring gene cell division cycle 37 pseudogene 2 Neighboring gene nuclear pore complex interacting protein family member B7 Neighboring gene CLN3 lysosomal/endosomal transmembrane protein, battenin Neighboring gene interleukin 27 Neighboring gene nuclear protein 1, transcriptional regulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
very-low-density lipoprotein particle receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
lipid transport IEA
Inferred from Electronic Annotation
more info
 
triglyceride metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very-low-density lipoprotein particle clearance TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
chylomicron IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
very-low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
apolipoprotein B receptor
Names
apoB-48R
apolipoprotein B-100 receptor
apolipoprotein B-48 receptor
apolipoprotein B100 receptor
apolipoprotein B48 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018690.4NP_061160.3  apolipoprotein B receptor

    Status: REVIEWED

    Source sequence(s)
    AC138894
    Consensus CDS
    CCDS58442.1
    UniProtKB/Swiss-Prot
    Q0VD83
    Related
    ENSP00000457539.1, ENST00000564831.6
    Conserved Domains (1) summary
    TIGR00927
    Location:108362
    2A1904; K+-dependent Na+/Ca+ exchanger

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    28494643..28498964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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