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inpp5d inositol polyphosphate-5-phosphatase D [ Danio rerio (zebrafish) ]

Gene ID: 559103, updated on 9-Sep-2025
Official Symbol
inpp5dprovided by ZNC
Official Full Name
inositol polyphosphate-5-phosphatase Dprovided by ZNC
Primary source
ZFIN:ZDB-GENE-100922-30
See related
Ensembl:ENSDARG00000074283 AllianceGenome:ZFIN:ZDB-GENE-100922-30
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch73-194h10.1
Summary
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. Acts upstream of or within negative regulation of neutrophil chemotaxis. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Predicted to be active in cytosol. Orthologous to human INPP5D (inositol polyphosphate-5-phosphatase D). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See inpp5d in Genome Data Viewer
Location:
chromosome: 6
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 6 NC_133181.1 (30639319..30690858)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 6 NC_007117.7 (28140956..28192541)

Chromosome 6 - NC_133181.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141386287 Neighboring gene si:ch73-194h10.3 Neighboring gene si:ch73-14h10.2 Neighboring gene G protein-coupled receptor 17 Neighboring gene smx5 Neighboring gene LIM domain containing preferred translocation partner in lipoma

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish. Lam PY, et al. J Cell Sci, 2012 Nov 1. PMID 22946052, Free PMC Article
  2. Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Chestnut B, et al. Dev Dyn, 2020 Feb. PMID 31705559, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SHIP phosphatases control neutrophil inflammation by limiting neutrophil motility in vivo.
    Title: The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of neutrophil differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Names
SHIP1
inositol polyphosphate-5-phosphatase, 145kDa
XP_021329769.1
XP_068075314.1

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133181.1 Reference GRCz12tu Primary Assembly

    Range
    30639319..30690858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474094.3 → XP_021329769.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M1QLP5, A0A8M9Q0J1
    Conserved Domains (3) summary
    cd10343
    Location:3 → 105
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    cl00490
    Location:401 → 707
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    cl27975
    Location:935 → 1088
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

  2. XM_068219213.2 → XP_068075314.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M1QLP5, A0AB32THI2
Nucleotide Protein Strain
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