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ANGPTL8 angiopoietin like 8 [ Homo sapiens (human) ]

Gene ID: 55908, updated on 24-Nov-2020

Summary

Official Symbol
ANGPTL8provided by HGNC
Official Full Name
angiopoietin like 8provided by HGNC
Primary source
HGNC:HGNC:24933
See related
Ensembl:ENSG00000130173 MIM:616223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIFL; TD26; PRO1185; PVPA599; C19orf80
Expression
Biased expression in liver (RPKM 32.5) and fat (RPKM 10.2) See more
Orthologs

Genomic context

See ANGPTL8 in Genome Data Viewer
Location:
19p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (11239619..11241943)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11350295..11352619)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene KN motif and ankyrin repeat domains 2 Neighboring gene uncharacterized LOC105372273 Neighboring gene dedicator of cytokinesis 6 Neighboring gene tetraspanin 16 Neighboring gene uncharacterized HSPC102 Neighboring gene RAB3D, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hormone activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cellular lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein processing IDA
Inferred from Direct Assay
more info
PubMed 
regulation of lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of lipoprotein lipase activity TAS
Traceable Author Statement
more info
 
regulation of lipoprotein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
triglyceride homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triglyceride homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT type B pancreatic cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
angiopoietin-like protein 8
Names
betatrophin variant 1
betatrophin variant 2
hepatocellular carcinoma-associated gene TD26
hepatocellular carcinoma-associated protein TD26
lipasin
refeeding-induced fat and liver protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018687.7NP_061157.3  angiopoietin-like protein 8 precursor

    See identical proteins and their annotated locations for NP_061157.3

    Status: VALIDATED

    Source sequence(s)
    AY358356, BF511595, BP316755
    Consensus CDS
    CCDS54220.1
    UniProtKB/Swiss-Prot
    Q6UXH0
    Related
    ENSP00000252453.7, ENST00000252453.12

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    11239619..11241943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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