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ANGPTL8 angiopoietin like 8 [ Homo sapiens (human) ]

Gene ID: 55908, updated on 25-Jan-2022

Summary

Official Symbol
ANGPTL8provided by HGNC
Official Full Name
angiopoietin like 8provided by HGNC
Primary source
HGNC:HGNC:24933
See related
Ensembl:ENSG00000130173 MIM:616223; AllianceGenome:HGNC:24933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIFL; TD26; PRO1185; PVPA599; C19orf80
Summary
Predicted to enable hormone activity. Involved in regulation of lipid metabolic process and triglyceride homeostasis. Acts upstream of or within positive regulation of protein processing and regulation of lipoprotein metabolic process. Located in extracellular region. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in liver (RPKM 32.5) and fat (RPKM 10.2) See more
Orthologs
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Genomic context

See ANGPTL8 in Genome Data Viewer
Location:
19p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (11239619..11241943)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11350295..11352619)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene KN motif and ankyrin repeat domains 2 Neighboring gene uncharacterized LOC105372273 Neighboring gene dedicator of cytokinesis 6 Neighboring gene tetraspanin 16 Neighboring gene uncharacterized HSPC102 Neighboring gene RAB3D, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
angiopoietin-like protein 8
Names
betatrophin variant 1
betatrophin variant 2
hepatocellular carcinoma-associated gene TD26
hepatocellular carcinoma-associated protein TD26
lipasin
refeeding-induced fat and liver protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018687.7NP_061157.3  angiopoietin-like protein 8 precursor

    See identical proteins and their annotated locations for NP_061157.3

    Status: VALIDATED

    Source sequence(s)
    AY358356, BF511595, BP316755
    Consensus CDS
    CCDS54220.1
    UniProtKB/Swiss-Prot
    Q6UXH0
    Related
    ENSP00000252453.7, ENST00000252453.12

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    11239619..11241943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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