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RNF114 ring finger protein 114 [ Homo sapiens (human) ]

Gene ID: 55905, updated on 5-Apr-2020

Summary

Official Symbol
RNF114provided by HGNC
Official Full Name
ring finger protein 114provided by HGNC
Primary source
HGNC:HGNC:13094
See related
Ensembl:ENSG00000124226 MIM:612451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF313; PSORS12
Expression
Ubiquitous expression in testis (RPKM 40.7), spleen (RPKM 29.3) and 25 other tissues See more
Orthologs

Genomic context

See RNF114 in Genome Data Viewer
Location:
20q13.13
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (49936397..49953885)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (48552914..48570422)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 2 Neighboring gene uncharacterized LOC105372653 Neighboring gene keratin 18 pseudogene 4 Neighboring gene RNA, U6 small nuclear 147, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
NHGRI GWA Catalog
Genome-wide association analysis identifies three psoriasis susceptibility loci.
NHGRI GWA Catalog
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intracellular IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF114
Names
RING-type E3 ubiquitin transferase RNF114
zinc finger protein 228
zinc finger protein 313
NP_061153.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018683.4NP_061153.1  E3 ubiquitin-protein ligase RNF114

    See identical proteins and their annotated locations for NP_061153.1

    Status: VALIDATED

    Source sequence(s)
    AF131742, AK091976, BC013695, BM830132
    Consensus CDS
    CCDS33482.1
    UniProtKB/Swiss-Prot
    Q9Y508
    Related
    ENSP00000244061.2, ENST00000244061.6
    Conserved Domains (2) summary
    pfam05605
    Location:140200
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    cd16540
    Location:2768
    RING-HC_RNF114; RING finger, HC subclass, found in RING finger protein 114 (RNF114) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    49936397..49953885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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