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ZNF302 zinc finger protein 302 [ Homo sapiens (human) ]

Gene ID: 55900, updated on 1-Jun-2020

Summary

Official Symbol
ZNF302provided by HGNC
Official Full Name
zinc finger protein 302provided by HGNC
Primary source
HGNC:HGNC:13848
See related
Ensembl:ENSG00000089335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSD16; MST154; ZNF327; MSTP154; ZNF135L; ZNF140L
Summary
This gene encodes a member of the zinc-finger protein family. The encoded protein contains seven C2H2-type zinc fingers and a KRAB domain, but its function has yet to be determined. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in ovary (RPKM 11.7), endometrium (RPKM 10.4) and 25 other tissues See more
Orthologs

Genomic context

See ZNF302 in Genome Data Viewer
Location:
19q13.11
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (34677639..34686397)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35168553..35177302)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene secretoglobin family 1B member 2, pseudogene Neighboring gene secretoglobin family 2B member 3, pseudogene Neighboring gene secretoglobin family 1B member 3, pseudogene Neighboring gene secretoglobin family 2B member 1, pseudogene Neighboring gene secretoglobin family 1B member 1, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 302
Names
zinc finger protein 327

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033997.1 RefSeqGene

    Range
    5001..13759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012320.2NP_001012320.1  zinc finger protein 302 isoform c

    See identical proteins and their annotated locations for NP_001012320.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a. Variants 1, 2, 5, 8, and 9 all encode the same isoform (c).
    Source sequence(s)
    AL834318, DB066674
    Consensus CDS
    CCDS46042.1
    UniProtKB/Swiss-Prot
    Q9NR11
    Related
    ENSP00000391067.2, ENST00000457781.6
    Conserved Domains (3) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:132348
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:287307
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001289181.1NP_001276110.1  zinc finger protein 302 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (a).
    Source sequence(s)
    AK131278, AL834318, DB066674
    Consensus CDS
    CCDS74330.1
    UniProtKB/Swiss-Prot
    Q9NR11
    UniProtKB/TrEMBL
    B3KY96, E7EVR1
    Related
    ENSP00000396379.2, ENST00000446502.6
    Conserved Domains (5) summary
    smart00349
    Location:48108
    KRAB; krueppel associated box
    COG5048
    Location:150392
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:331351
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4887
    KRAB; KRAB box
    pfam13465
    Location:287312
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001289182.1NP_001276111.1  zinc finger protein 302 isoform b

    See identical proteins and their annotated locations for NP_001276111.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, uses an alternate in-frame splice junction, and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 4, 6, and 7 all encode the same isoform (b).
    Source sequence(s)
    AC020910, AL834318, DA792042, DA793666, DB066674
    Consensus CDS
    CCDS74332.1
    UniProtKB/Swiss-Prot
    Q9NR11
    UniProtKB/TrEMBL
    A0A087WYF4
    Related
    ENSP00000481754.1, ENST00000613363.4
    Conserved Domains (3) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    COG5048
    Location:133349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:288308
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001289183.1NP_001276112.1  zinc finger protein 302 isoform c

    See identical proteins and their annotated locations for NP_001276112.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a. Variants 1, 2, 5, 8, and 9 all encode the same isoform (c).
    Source sequence(s)
    AL834318, DA749741, DB066674
    Consensus CDS
    CCDS46042.1
    UniProtKB/Swiss-Prot
    Q9NR11
    Conserved Domains (3) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:132348
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:287307
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001289184.1NP_001276113.1  zinc finger protein 302 isoform b

    See identical proteins and their annotated locations for NP_001276113.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice junction and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 4, 6, and 7 all encode the same isoform (b).
    Source sequence(s)
    AL834318, DA790162, DB066674
    Consensus CDS
    CCDS74332.1
    UniProtKB/Swiss-Prot
    Q9NR11
    UniProtKB/TrEMBL
    A0A087WYF4
    Conserved Domains (3) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    COG5048
    Location:133349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:288308
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001289185.1NP_001276114.1  zinc finger protein 302 isoform b

    See identical proteins and their annotated locations for NP_001276114.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, uses an alternate in-frame splice junction, and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 4, 6, and 7 all encode the same isoform (b).
    Source sequence(s)
    AC020910, AL834318, DA297006, DB066674
    Consensus CDS
    CCDS74332.1
    UniProtKB/Swiss-Prot
    Q9NR11
    UniProtKB/TrEMBL
    A0A087WYF4
    Conserved Domains (3) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    COG5048
    Location:133349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:288308
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_001289186.1NP_001276115.1  zinc finger protein 302 isoform c

    See identical proteins and their annotated locations for NP_001276115.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a. Variants 1, 2, 5, 8, and 9 all encode the same isoform (c).
    Source sequence(s)
    AL834318, DA780378, DB066674
    Consensus CDS
    CCDS46042.1
    UniProtKB/Swiss-Prot
    Q9NR11
    Conserved Domains (3) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:132348
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:287307
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. NM_001289187.2NP_001276116.1  zinc finger protein 302 isoform c

    See identical proteins and their annotated locations for NP_001276116.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a. Variants 1, 2, 5, 8, and 9 all encode the same isoform (c).
    Source sequence(s)
    AC020910, AL834318, DA793666, DB066674, DN997090
    Consensus CDS
    CCDS46042.1
    UniProtKB/Swiss-Prot
    Q9NR11
    Related
    ENSP00000421028.1, ENST00000505242.6
    Conserved Domains (3) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:132348
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:287307
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. NM_001289188.2NP_001276117.1  zinc finger protein 302 isoform d

    See identical proteins and their annotated locations for NP_001276117.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, uses an alternate in-frame splice junction, lacks an alternate in-frame exon, and uses another alternate splice junction compared to variant 3. The resulting isoform (d) lacks an alternate internal segment, contains an additional internal aa, and has a shorter and distinct C-terminus compared to isoform a. Variants 10 and 11 both encode the same isoform (d).
    Source sequence(s)
    AC020910, AK297551, AL834318, BI562204
    Consensus CDS
    CCDS74331.1
    UniProtKB/Swiss-Prot
    Q9NR11
    UniProtKB/TrEMBL
    B4DMN2
    Related
    ENSP00000424292.1, ENST00000506901.5
    Conserved Domains (2) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    pfam01352
    Location:443
    KRAB; KRAB box
  10. NM_001289189.2NP_001276118.1  zinc finger protein 302 isoform d

    See identical proteins and their annotated locations for NP_001276118.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, uses an alternate in-frame splice junction, lacks an alternate in-frame exon, and uses another alternate splice junction compared to variant 3. The resulting isoform (d) lacks an alternate internal segment, contains an additional internal aa, and has a shorter and distinct C-terminus compared to isoform a. Variants 10 and 11 both encode the same isoform (d).
    Source sequence(s)
    AC020910, AK297551, AL834318, BG926751, DB066674
    Consensus CDS
    CCDS74331.1
    UniProtKB/Swiss-Prot
    Q9NR11
    UniProtKB/TrEMBL
    B4DMN2
    Related
    ENSP00000421201.1, ENST00000507959.5
    Conserved Domains (2) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    pfam01352
    Location:443
    KRAB; KRAB box
  11. NM_001289190.2NP_001276119.1  zinc finger protein 302 isoform e

    See identical proteins and their annotated locations for NP_001276119.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate splice junction compared to variant 1. The resulting isoform (e) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform a. Variants 12, 13, 14, and 15 all encode the same isoform (e).
    Source sequence(s)
    AC020910, AK297551, AL834318, BG926751, DA300773, DB066674
    Consensus CDS
    CCDS74333.1
    UniProtKB/Swiss-Prot
    Q9NR11
    UniProtKB/TrEMBL
    B4DMN2, D6R9Q0
    Related
    ENSP00000423460.1, ENST00000502743.5
    Conserved Domains (2) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    pfam01352
    Location:443
    KRAB; KRAB box
  12. NM_001289191.2NP_001276120.1  zinc finger protein 302 isoform e

    See identical proteins and their annotated locations for NP_001276120.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate splice junction compared to variant 1. The resulting isoform (e) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform a. Variants 12, 13, 14, and 15 all encode the same isoform (e).
    Source sequence(s)
    AC020910, AK297551, AL834318, BG926751, DA300773, HY117192
    Consensus CDS
    CCDS74333.1
    UniProtKB/Swiss-Prot
    Q9NR11
    UniProtKB/TrEMBL
    B4DMN2, D6R9Q0
    Conserved Domains (2) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    pfam01352
    Location:443
    KRAB; KRAB box
  13. NM_001289192.2NP_001276121.1  zinc finger protein 302 isoform e

    See identical proteins and their annotated locations for NP_001276121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) lacks an alternate in-frame exon and uses an alternate splice junction compared to variant 1. The resulting isoform (e) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform a. Variants 12, 13, 14, and 15 all encode the same isoform (e).
    Source sequence(s)
    AC020910, AK297551, AL834318, BG926751, DA300773, DA487799, DB066674
    Consensus CDS
    CCDS74333.1
    UniProtKB/Swiss-Prot
    Q9NR11
    UniProtKB/TrEMBL
    B4DMN2, D6R9Q0
    Conserved Domains (2) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    pfam01352
    Location:443
    KRAB; KRAB box
  14. NM_018443.3NP_060913.2  zinc finger protein 302 isoform c

    See identical proteins and their annotated locations for NP_060913.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a. Variants 1, 2, 5, 8, and 9 all encode the same isoform (c).
    Source sequence(s)
    AK074901, AL834318, DB066674
    Consensus CDS
    CCDS46042.1
    UniProtKB/Swiss-Prot
    Q9NR11
    UniProtKB/TrEMBL
    Q8NC84
    Related
    ENSP00000405219.2, ENST00000423823.6
    Conserved Domains (3) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:132348
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:287307
    ZF_C2H2; C2H2 Zn finger [structural motif]
  15. NM_018675.3NP_061145.2  zinc finger protein 302 isoform e

    See identical proteins and their annotated locations for NP_061145.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate splice junction compared to variant 1. The resulting isoform (e) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform a. Variants 12, 13, 14, and 15 all encode the same isoform (e).
    Source sequence(s)
    AC020910, AF265236, AK297551, AL834318, DB066674
    Consensus CDS
    CCDS74333.1
    UniProtKB/Swiss-Prot
    Q9NR11
    UniProtKB/TrEMBL
    B4DMN2, D6R9Q0
    Related
    ENSP00000423235.1, ENST00000505365.2
    Conserved Domains (2) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    pfam01352
    Location:443
    KRAB; KRAB box

RNA

  1. NR_110322.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) lacks three exons compared to variant 3. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL834318, DA773435, DB066674

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    34677639..34686397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026978.1XP_016882467.1  zinc finger protein 302 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:48109
    KRAB; krueppel associated box
    COG5048
    Location:151393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332352
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_017026979.1XP_016882468.1  zinc finger protein 302 isoform X2

    UniProtKB/TrEMBL
    E7EVR1
    Conserved Domains (5) summary
    smart00349
    Location:48108
    KRAB; krueppel associated box
    COG5048
    Location:150392
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:331351
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4887
    KRAB; KRAB box
    pfam13465
    Location:287312
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017026986.1XP_016882475.1  zinc finger protein 302 isoform X6

    UniProtKB/TrEMBL
    B4DMN2
    Conserved Domains (2) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    pfam01352
    Location:443
    KRAB; KRAB box
  4. XM_024451607.1XP_024307375.1  zinc finger protein 302 isoform X5

    Conserved Domains (1) summary
    smart00349
    Location:48108
    KRAB; krueppel associated box
  5. XM_017026985.1XP_016882474.1  zinc finger protein 302 isoform X5

    Conserved Domains (1) summary
    smart00349
    Location:48108
    KRAB; krueppel associated box
  6. XM_024451603.1XP_024307371.1  zinc finger protein 302 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:48109
    KRAB; krueppel associated box
    COG5048
    Location:151393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332352
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_024451605.1XP_024307373.1  zinc finger protein 302 isoform X4

    Conserved Domains (1) summary
    smart00349
    Location:48109
    KRAB; krueppel associated box
  8. XM_024451606.1XP_024307374.1  zinc finger protein 302 isoform X5

    Conserved Domains (1) summary
    smart00349
    Location:48108
    KRAB; krueppel associated box
  9. XM_017026983.1XP_016882472.1  zinc finger protein 302 isoform X4

    Conserved Domains (1) summary
    smart00349
    Location:48109
    KRAB; krueppel associated box
  10. XM_017026980.2XP_016882469.1  zinc finger protein 302 isoform X2

    UniProtKB/TrEMBL
    E7EVR1
    Conserved Domains (5) summary
    smart00349
    Location:48108
    KRAB; krueppel associated box
    COG5048
    Location:150392
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:331351
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4887
    KRAB; KRAB box
    pfam13465
    Location:287312
    zf-H2C2_2; Zinc-finger double domain
  11. XM_011527111.3XP_011525413.1  zinc finger protein 302 isoform X6

    See identical proteins and their annotated locations for XP_011525413.1

    UniProtKB/TrEMBL
    B4DMN2
    Conserved Domains (2) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    pfam01352
    Location:443
    KRAB; KRAB box
  12. XM_017026981.2XP_016882470.1  zinc finger protein 302 isoform X2

    UniProtKB/TrEMBL
    E7EVR1
    Conserved Domains (5) summary
    smart00349
    Location:48108
    KRAB; krueppel associated box
    COG5048
    Location:150392
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:331351
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4887
    KRAB; KRAB box
    pfam13465
    Location:287312
    zf-H2C2_2; Zinc-finger double domain
  13. XM_017026982.1XP_016882471.1  zinc finger protein 302 isoform X3

    UniProtKB/TrEMBL
    A0A087WYF4
    Conserved Domains (3) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    COG5048
    Location:133349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:288308
    ZF_C2H2; C2H2 Zn finger [structural motif]
  14. XM_024451604.1XP_024307372.1  zinc finger protein 302 isoform X3

    Conserved Domains (3) summary
    smart00349
    Location:465
    KRAB; krueppel associated box
    COG5048
    Location:133349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:288308
    ZF_C2H2; C2H2 Zn finger [structural motif]
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