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UNC45A unc-45 myosin chaperone A [ Homo sapiens (human) ]

Gene ID: 55898, updated on 23-Dec-2018

Summary

Official Symbol
UNC45Aprovided by HGNC
Official Full Name
unc-45 myosin chaperone Aprovided by HGNC
Primary source
HGNC:HGNC:30594
See related
Ensembl:ENSG00000140553 MIM:611219
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMAP1; SMAP-1; GCUNC45; UNC-45A; GC-UNC45; GCUNC-45; IRO039700
Summary
This gene encodes a regulatory component of the progesterone receptor/heat shock protein 90 chaperoning complex, which functions in the assembly and folding of the progesterone receptor. The encoded protein is thought to be essential for normal cell proliferation, and for the accumulation of myosin during development of muscle cells. [provided by RefSeq, Sep 2018]
Expression
Ubiquitous expression in prostate (RPKM 14.4), skin (RPKM 14.0) and 25 other tissues See more
Orthologs

Genomic context

See UNC45A in Genome Data Viewer
Location:
15q26.1
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (90930180..90954093)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91473410..91497323)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene FES proto-oncogene, tyrosine kinase Neighboring gene mannosidase alpha class 2A member 2 Neighboring gene HD domain containing 3 Neighboring gene RCC1 domain containing 1 Neighboring gene PRC1 antisense RNA 1 Neighboring gene protein regulator of cytokinesis 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 NL4-3 replication requires UNC45A as replication is inhibited when UNC45A is deleted through CRISPR/Cas9 genome editing PubMed

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol HIV-1 IN is identified to have a physical interaction with unc-45 homolog A (C. elegans) (UNC45A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10043

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle organ development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein unc-45 homolog A
Names
general cell UNC45
smooth muscle cell associated protein-1
unc-45 homolog A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_061633.1 RefSeqGene

    Range
    10106..28914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039675.1NP_001034764.1  protein unc-45 homolog A isoform 3

    See identical proteins and their annotated locations for NP_001034764.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has a longer 5' UTR, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 2. The encoded isoform (3) is shorter, compared to isoform 2.
    Source sequence(s)
    AK125721, BC006214
    Consensus CDS
    CCDS42082.1
    UniProtKB/Swiss-Prot
    Q9H3U1
    Related
    ENSP00000377816.2, ENST00000394275.6
    Conserved Domains (6) summary
    cd00020
    Location:669788
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00006
    Location:634
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:77110
    TPR_1; Tetratricopeptide repeat
    pfam11701
    Location:348490
    UNC45-central; Myosin-binding striated muscle assembly central
    pfam13414
    Location:773
    TPR_11; TPR repeat
    sd00043
    Location:753788
    ARM; armadillo repeat [structural motif]
  2. NM_001323619.1NP_001310548.1  protein unc-45 homolog A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC068831
    Consensus CDS
    CCDS10367.1
    UniProtKB/Swiss-Prot
    Q9H3U1
    Conserved Domains (4) summary
    sd00006
    Location:2149
    TPR; TPR repeat [structural motif]
    sd00043
    Location:768803
    ARM; armadillo repeat [structural motif]
    pfam11701
    Location:363505
    UNC45-central; Myosin-binding striated muscle assembly central
    cl26005
    Location:23144
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  3. NM_001323620.1NP_001310549.1  protein unc-45 homolog A isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC068831
    Conserved Domains (2) summary
    sd00043
    Location:623658
    ARM; armadillo repeat [structural motif]
    pfam11701
    Location:218360
    UNC45-central; Myosin-binding striated muscle assembly central
  4. NM_001323621.1NP_001310550.1  protein unc-45 homolog A isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC068831
    Consensus CDS
    CCDS42082.1
    UniProtKB/Swiss-Prot
    Q9H3U1
    Conserved Domains (6) summary
    cd00020
    Location:669788
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00006
    Location:634
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:77110
    TPR_1; Tetratricopeptide repeat
    pfam11701
    Location:348490
    UNC45-central; Myosin-binding striated muscle assembly central
    pfam13414
    Location:773
    TPR_11; TPR repeat
    sd00043
    Location:753788
    ARM; armadillo repeat [structural motif]
  5. NM_018671.5NP_061141.2  protein unc-45 homolog A isoform 2

    See identical proteins and their annotated locations for NP_061141.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (2).
    Source sequence(s)
    AB014736, BC006214, DC382051
    Consensus CDS
    CCDS10367.1
    UniProtKB/Swiss-Prot
    Q9H3U1
    Related
    ENSP00000407487.2, ENST00000418476.2
    Conserved Domains (4) summary
    sd00006
    Location:2149
    TPR; TPR repeat [structural motif]
    sd00043
    Location:768803
    ARM; armadillo repeat [structural motif]
    pfam11701
    Location:363505
    UNC45-central; Myosin-binding striated muscle assembly central
    cl26005
    Location:23144
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    90930180..90954093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449984.1XP_024305752.1  protein unc-45 homolog A isoform X1

    Conserved Domains (2) summary
    sd00043
    Location:623658
    ARM; armadillo repeat [structural motif]
    pfam11701
    Location:218360
    UNC45-central; Myosin-binding striated muscle assembly central
  2. XM_024449985.1XP_024305753.1  protein unc-45 homolog A isoform X1

    Conserved Domains (2) summary
    sd00043
    Location:623658
    ARM; armadillo repeat [structural motif]
    pfam11701
    Location:218360
    UNC45-central; Myosin-binding striated muscle assembly central
  3. XM_024449983.1XP_024305751.1  protein unc-45 homolog A isoform X1

    Conserved Domains (2) summary
    sd00043
    Location:623658
    ARM; armadillo repeat [structural motif]
    pfam11701
    Location:218360
    UNC45-central; Myosin-binding striated muscle assembly central
  4. XM_005254963.4XP_005255020.1  protein unc-45 homolog A isoform X1

    Conserved Domains (2) summary
    sd00043
    Location:623658
    ARM; armadillo repeat [structural motif]
    pfam11701
    Location:218360
    UNC45-central; Myosin-binding striated muscle assembly central
  5. XM_017022407.2XP_016877896.1  protein unc-45 homolog A isoform X2

    Conserved Domains (2) summary
    sd00043
    Location:330365
    ARM; armadillo repeat [structural motif]
    pfam11701
    Location:167
    UNC45-central; Myosin-binding striated muscle assembly central
  6. XM_011521780.3XP_011520082.1  protein unc-45 homolog A isoform X2

    Conserved Domains (2) summary
    sd00043
    Location:330365
    ARM; armadillo repeat [structural motif]
    pfam11701
    Location:167
    UNC45-central; Myosin-binding striated muscle assembly central
  7. XM_024449986.1XP_024305754.1  protein unc-45 homolog A isoform X2

    Conserved Domains (2) summary
    sd00043
    Location:330365
    ARM; armadillo repeat [structural motif]
    pfam11701
    Location:167
    UNC45-central; Myosin-binding striated muscle assembly central

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017979.1: Suppressed sequence

    Description
    NM_017979.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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