Format

Send to:

Choose Destination

MESP1 mesoderm posterior bHLH transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 55897, updated on 13-Mar-2020

Summary

Official Symbol
MESP1provided by HGNC
Official Full Name
mesoderm posterior bHLH transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:29658
See related
Ensembl:ENSG00000166823 MIM:608689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bHLHc5
Expression
Biased expression in fat (RPKM 4.6), prostate (RPKM 4.1) and 4 other tissues See more
Orthologs

Genomic context

See MESP1 in Genome Data Viewer
Location:
15q26.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (89734772..89751309, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90293098..90294540, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 11 alpha Neighboring gene ribosomal protein L36a pseudogene 43 Neighboring gene WD repeat domain 93 Neighboring gene RNA, U6 small nuclear 132, pseudogene Neighboring gene mitochondrial ribosomal protein L15 pseudogene 1 Neighboring gene mesoderm posterior bHLH transcription factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC10676

Gene Ontology Provided by GOA

Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cardiac atrium formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac cell fate determination ISS
Inferred from Sequence or Structural Similarity
more info
 
cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac vascular smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac ventricle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardioblast anterior-lateral migration ISS
Inferred from Sequence or Structural Similarity
more info
 
cardioblast migration to the midline involved in heart field formation ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic heart tube morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
 
gene expression IEA
Inferred from Electronic Annotation
more info
 
growth involved in heart morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
heart looping ISS
Inferred from Sequence or Structural Similarity
more info
 
heart morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lateral mesoderm development ISS
Inferred from Sequence or Structural Similarity
more info
 
mesoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mesodermal cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endodermal cell fate specification ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of mesodermal cell fate specification ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Notch signaling pathway involved in heart induction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of hepatocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of striated muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
secondary heart field specification ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction involved in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
sinoatrial node cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
sinus venosus morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
somitogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
mesoderm posterior protein 1
Names
class C basic helix-loop-helix protein 5
mesoderm posterior 1 homolog
mesoderm posterior basic helix-loop-helix transcription factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018670.3NP_061140.1  mesoderm posterior protein 1

    See identical proteins and their annotated locations for NP_061140.1

    Status: VALIDATED

    Source sequence(s)
    AL357533, BC006219, BP212916
    Consensus CDS
    CCDS10355.1
    UniProtKB/Swiss-Prot
    Q9BRJ9
    Related
    ENSP00000300057.4, ENST00000300057.4
    Conserved Domains (1) summary
    pfam00010
    Location:83136
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    89734772..89751309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001751353.1 RNA Sequence

  2. XR_001751352.1 RNA Sequence

  3. XR_001751350.1 RNA Sequence

  4. XR_001751351.1 RNA Sequence

  5. XR_001751354.1 RNA Sequence

Support Center