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MYNN myoneurin [ Homo sapiens (human) ]

Gene ID: 55892, updated on 7-Jun-2020

Summary

Official Symbol
MYNNprovided by HGNC
Official Full Name
myoneurinprovided by HGNC
Primary source
HGNC:HGNC:14955
See related
Ensembl:ENSG00000085274 MIM:606042
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OSZF; SBBIZ1; ZBTB31; ZNF902
Summary
This gene encodes a member of the BTB/POZ and zinc finger domain-containing protein family that are involved in the control of gene expression. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 14. [provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 4.7), testis (RPKM 4.6) and 25 other tissues See more
Orthologs

Genomic context

See MYNN in Genome Data Viewer
Location:
3q26.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (169773396..169789716)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (169490619..169507504)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene actin related protein T3 Neighboring gene Sharpr-MPRA regulatory region 7912 Neighboring gene tRNA-Val (anticodon AAC) 1-1 Neighboring gene leucine rich repeat containing 34 Neighboring gene leucine rich repeats and IQ motif containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.
NHGRI GWA Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
NHGRI GWA Catalog
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans.
NHGRI GWA Catalog
Identification of seven loci affecting mean telomere length and their association with disease.
NHGRI GWA Catalog
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
NHGRI GWA Catalog
Multiple common variants for celiac disease influencing immune gene expression.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
myoneurin
Names
zinc finger and BTB domain-containing protein 31
zinc finger protein with BTB/POZ domain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185118.2NP_001172047.1  myoneurin isoform A

    See identical proteins and their annotated locations for NP_001172047.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an additional exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein (isoform A).
    Source sequence(s)
    AC078795, AF148848, BX648128, DB134736
    Consensus CDS
    CCDS3207.1
    UniProtKB/Swiss-Prot
    Q9NPC7
    Related
    ENSP00000349150.3, ENST00000356716.8
    Conserved Domains (5) summary
    COG5189
    Location:354438
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:304324
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304324
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14115
    BTB; BTB/POZ domain
    pfam13465
    Location:316341
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001185119.1NP_001172048.1  myoneurin isoform B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform B), compared to isoform A.
    Source sequence(s)
    AB079778, AC078795, DB134736
    Consensus CDS
    CCDS54671.1
    UniProtKB/Swiss-Prot
    Q9NPC7
    Related
    ENSP00000440637.1, ENST00000544106.5
    Conserved Domains (6) summary
    COG5048
    Location:385535
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:354438
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:304324
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304324
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14115
    BTB; BTB/POZ domain
    pfam13465
    Location:316341
    zf-H2C2_2; Zinc-finger double domain
  3. NM_018657.5NP_061127.1  myoneurin isoform A

    See identical proteins and their annotated locations for NP_061127.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (A). Both variants 1 and 2 encode the same protein (isoform A).
    Source sequence(s)
    AC078795, BX648128, DB134736
    Consensus CDS
    CCDS3207.1
    UniProtKB/Swiss-Prot
    Q9NPC7
    Related
    ENSP00000326240.4, ENST00000349841.9
    Conserved Domains (5) summary
    COG5189
    Location:354438
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:304324
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304324
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14115
    BTB; BTB/POZ domain
    pfam13465
    Location:316341
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_033702.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in an internal coding exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC078795, AK304281, BX648128, DB134736
  2. NR_033703.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in an internal coding exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC078795, AC078802, AF155508, BX648128, DB134736

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    169773396..169789716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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