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ZKSCAN7 zinc finger with KRAB and SCAN domains 7 [ Homo sapiens (human) ]

Gene ID: 55888, updated on 5-Aug-2022

Summary

Official Symbol
ZKSCAN7provided by HGNC
Official Full Name
zinc finger with KRAB and SCAN domains 7provided by HGNC
Primary source
HGNC:HGNC:12955
See related
Ensembl:ENSG00000196345 AllianceGenome:HGNC:12955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP; ZNF64; ZNF167; ZNF448; ZSCAN39
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 2.4), testis (RPKM 2.0) and 25 other tissues See more
Orthologs
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Genomic context

See ZKSCAN7 in Genome Data Viewer
Location:
3p21.31
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44555193..44583483)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44570938..44599205)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44596685..44624975)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 852 pseudogene Neighboring gene Sharpr-MPRA regulatory region 15293 Neighboring gene ZKSCAN7 ZNF cluster antisense RNA 1 Neighboring gene ZNF660-ZNF197 readthrough Neighboring gene myosin phosphatase Rho interacting protein pseudogene 1 Neighboring gene zinc finger protein 660 Neighboring gene ZNF197 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12738

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein with KRAB and SCAN domains 7
Names
zinc finger protein 167
zinc finger protein 448
zinc finger protein 64

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288590.2NP_001275519.1  zinc finger protein with KRAB and SCAN domains 7 isoform 1

    See identical proteins and their annotated locations for NP_001275519.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AK291285, AY280798
    Consensus CDS
    CCDS2715.1
    UniProtKB/Swiss-Prot
    Q96FQ2, Q9P0L1
    Related
    ENSP00000395524.1, ENST00000426540.6
    Conserved Domains (7) summary
    smart00431
    Location:51161
    SCAN; leucine rich region
    cd07765
    Location:231270
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:380738
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:637657
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:383405
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:51138
    SCAN; SCAN domain
    pfam13465
    Location:677701
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001288591.2NP_001275520.1  zinc finger protein with KRAB and SCAN domains 7 isoform 2

    See identical proteins and their annotated locations for NP_001275520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 4 both encode the same isoform (2).
    Source sequence(s)
    AC099669, AK291285, BC010555, BC063020, BC120982
    Consensus CDS
    CCDS2714.1
    UniProtKB/Swiss-Prot
    Q9P0L1
    UniProtKB/TrEMBL
    Q0VAP0
    Related
    ENSP00000416681.1, ENST00000431636.5
    Conserved Domains (3) summary
    smart00431
    Location:51161
    SCAN; leucine rich region
    cd07765
    Location:231270
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    pfam02023
    Location:51138
    SCAN; SCAN domain
  3. NM_001288592.2NP_001275521.1  zinc finger protein with KRAB and SCAN domains 7 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences in the 5' UTR, 3' UTR, and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, lacks a single internal aa, and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC099669, AK291285, BC010555, BC148260
    Consensus CDS
    CCDS74924.1
    UniProtKB/Swiss-Prot
    Q9P0L1
    UniProtKB/TrEMBL
    A7MAY2, C9J6L6
    Related
    ENSP00000405034.1, ENST00000447279.2
    Conserved Domains (5) summary
    cd07765
    Location:81120
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:229291
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:232254
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:250271
    zf-H2C2_2; Zinc-finger double domain
  4. NM_018651.4NP_061121.2  zinc finger protein with KRAB and SCAN domains 7 isoform 1

    See identical proteins and their annotated locations for NP_061121.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AY280798, DA787920
    Consensus CDS
    CCDS2715.1
    UniProtKB/Swiss-Prot
    Q96FQ2, Q9P0L1
    Related
    ENSP00000273320.3, ENST00000273320.7
    Conserved Domains (7) summary
    smart00431
    Location:51161
    SCAN; leucine rich region
    cd07765
    Location:231270
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:380738
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:637657
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:383405
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:51138
    SCAN; SCAN domain
    pfam13465
    Location:677701
    zf-H2C2_2; Zinc-finger double domain
  5. NM_025169.3NP_079445.1  zinc finger protein with KRAB and SCAN domains 7 isoform 2

    See identical proteins and their annotated locations for NP_079445.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 4 both encode the same isoform (2).
    Source sequence(s)
    AC099669, BC010555, BC063020, DA787920
    Consensus CDS
    CCDS2714.1
    UniProtKB/Swiss-Prot
    Q9P0L1
    Related
    ENSP00000345404.3, ENST00000341840.7
    Conserved Domains (3) summary
    smart00431
    Location:51161
    SCAN; leucine rich region
    cd07765
    Location:231270
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    pfam02023
    Location:51138
    SCAN; SCAN domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44555193..44583483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448582.1XP_047304538.1  zinc finger protein with KRAB and SCAN domains 7 isoform X3

  2. XM_047448581.1XP_047304537.1  zinc finger protein with KRAB and SCAN domains 7 isoform X3

  3. XM_047448579.1XP_047304535.1  zinc finger protein with KRAB and SCAN domains 7 isoform X1

  4. XM_047448578.1XP_047304534.1  zinc finger protein with KRAB and SCAN domains 7 isoform X1

  5. XM_047448580.1XP_047304536.1  zinc finger protein with KRAB and SCAN domains 7 isoform X2

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p14 PATCHES

    Range
    80547..108837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44570938..44599205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)