exosc1 exosome component 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: exosc1provided by ZNC
Official Full Name: exosome component 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-080926-3
See related: Ensembl:ENSDARG00000059841 AllianceGenome:ZFIN:ZDB-GENE-080926-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable RNA binding activity. Predicted to act upstream of or within RNA processing. Predicted to be located in nucleolus. Predicted to be part of nuclear exosome (RNase complex). Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Orthologous to human EXOSC1 (exosome component 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (54700657..54706039, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (54023006..54028388, complement)
103	previous assembly	Zv9 (GCF_000002035.4)	1	NC_007112.5 (55240067..55245449, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of exosome (RNase complex)	IEA Inferred from Electronic Annotation more info
part_of nuclear exosome (RNase complex)	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: exosome complex component CSL4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145567.1 → NP_001139039.1 exosome complex component CSL4

Status: PROVISIONAL

Source sequence(s)

BX119918

UniProtKB/TrEMBL

A0A8M1NRG4, B8A4H5

Related

ENSDARP00000078068.5, ENSDART00000083633.6

Conserved Domains (3) summary

COG1096
Location:3 → 185

Csl4; Exosome complex RNA-binding protein Csl4, contains S1 and Zn-ribbon domains [Translation, ribosomal structure and biogenesis]

cd05791
Location:61 → 153

S1_CSL4; S1_CSL4: CSL4, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. ScCSL4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation ...

pfam14382
Location:6 → 40

ECR1_N; Exosome complex exonuclease RRP4 N-terminal region