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PBK PDZ binding kinase [ Homo sapiens (human) ]

Gene ID: 55872, updated on 1-Jun-2020

Summary

Official Symbol
PBKprovided by HGNC
Official Full Name
PDZ binding kinaseprovided by HGNC
Primary source
HGNC:HGNC:18282
See related
Ensembl:ENSG00000168078 MIM:611210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPK; CT84; TOPK; HEL164; Nori-3
Summary
This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Biased expression in testis (RPKM 35.2), lymph node (RPKM 5.8) and 8 other tissues See more
Orthologs

Genomic context

See PBK in Genome Data Viewer
Location:
8p21.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (27809624..27837817, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27667138..27695612, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986934 Neighboring gene coiled-coil domain containing 25 Neighboring gene RNA, U6 small nuclear 1276, pseudogene Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa pseudogene Neighboring gene SCARA5 intron CAGE-defined high expression enhancer Neighboring gene scavenger receptor class A member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14385

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lymphokine-activated killer T-cell-originated protein kinase
Names
MAPKK-like protein kinase
T-LAK cell-originated protein kinase
cancer/testis antigen 84
epididymis luminal protein 164
serine/threonine protein kinase
spermatogenesis-related protein kinase
NP_001265874.1
NP_001349969.1
NP_060962.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278945.2NP_001265874.1  lymphokine-activated killer T-cell-originated protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001265874.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is longer, compared to isoform 1.
    Source sequence(s)
    AK301836, BC015191, DB028500
    Consensus CDS
    CCDS64858.1
    UniProtKB/Swiss-Prot
    Q96KB5
    Related
    ENSP00000428489.1, ENST00000522944.5
    Conserved Domains (2) summary
    cd14001
    Location:32332
    PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase
    pfam00069
    Location:34327
    Pkinase; Protein kinase domain
  2. NM_001363040.2NP_001349969.1  lymphokine-activated killer T-cell-originated protein kinase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    BC015191, DC395891
    Consensus CDS
    CCDS6063.1
    Conserved Domains (1) summary
    cd14001
    Location:32321
    PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase
  3. NM_018492.4NP_060962.2  lymphokine-activated killer T-cell-originated protein kinase isoform 1

    See identical proteins and their annotated locations for NP_060962.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and encodes the shorter isoform (1). Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    BC015191, DB028500
    Consensus CDS
    CCDS6063.1
    UniProtKB/Swiss-Prot
    Q96KB5
    UniProtKB/TrEMBL
    V9HWH0
    Related
    ENSP00000301905.4, ENST00000301905.9
    Conserved Domains (1) summary
    cd14001
    Location:32321
    PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    27809624..27837817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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