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SLC22A11 solute carrier family 22 member 11 [ Homo sapiens (human) ]

Gene ID: 55867, updated on 23-Nov-2021

Summary

Official Symbol
SLC22A11provided by HGNC
Official Full Name
solute carrier family 22 member 11provided by HGNC
Primary source
HGNC:HGNC:18120
See related
Ensembl:ENSG00000168065 MIM:607097
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OAT4; hOAT4
Summary
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Biased expression in placenta (RPKM 19.0) and kidney (RPKM 17.4) See more
Orthologs
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Genomic context

See SLC22A11 in Genome Data Viewer
Location:
11q13.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (64555847..64572875)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64323413..64340347)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2724 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3159 Neighboring gene solute carrier family 22 member 12 Neighboring gene neurexin 2 Neighboring gene NRXN2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
GeneReviews: Not available
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
GeneReviews: Not available
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34282

General protein information

Preferred Names
solute carrier family 22 member 11
Names
organic anion transporter 4
solute carrier family 22 (organic anion/cation transporter), member 11
solute carrier family 22 (organic anion/urate transporter), member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307985.2NP_001294914.1  solute carrier family 22 member 11 isoform 2

    See identical proteins and their annotated locations for NP_001294914.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AA331094, AK129930, AP001092, BI051409, BX094958
    Consensus CDS
    CCDS76425.1
    UniProtKB/Swiss-Prot
    Q9NSA0
    Related
    ENSP00000366809.3, ENST00000377585.7
    Conserved Domains (2) summary
    cd06174
    Location:119277
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11351
    2A0119; cation transport protein
  2. NM_018484.4NP_060954.1  solute carrier family 22 member 11 isoform 1

    See identical proteins and their annotated locations for NP_060954.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA331094, AP001092, BC034384, BI051409, BX094958
    Consensus CDS
    CCDS8074.1
    UniProtKB/Swiss-Prot
    Q9NSA0
    Related
    ENSP00000301891.4, ENST00000301891.9
    Conserved Domains (1) summary
    cl26863
    Location:11523
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    64555847..64572875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545167.1XP_011543469.1  solute carrier family 22 member 11 isoform X1

    Conserved Domains (1) summary
    cd06174
    Location:33378
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
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