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KIZ kizuna centrosomal protein [ Homo sapiens (human) ]

Gene ID: 55857, updated on 24-Nov-2020

Summary

Official Symbol
KIZprovided by HGNC
Official Full Name
kizuna centrosomal proteinprovided by HGNC
Primary source
HGNC:HGNC:15865
See related
Ensembl:ENSG00000088970 MIM:615757
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RP69; HT013; Kizuna; PLK1S1; C20orf19; NCRNA00153
Summary
The protein encoded by this gene localizes to centrosomes, strengthening and stabilizing the pericentriolar region prior to spindle formation. The encoded protein usually remains with the mother centrosome after centrosomal duplication. Sevral transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Expression
Broad expression in testis (RPKM 20.1), ovary (RPKM 11.1) and 25 other tissues See more
Orthologs
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Genomic context

See KIZ in Genome Data Viewer
Location:
20p11.23
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (21125975..21246622)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (21106624..21227260)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9877 Neighboring gene long intergenic non-protein coding RNA 237 Neighboring gene RPL24 pseudogene 2 Neighboring gene RNA, 5S ribosomal pseudogene 477 Neighboring gene ribosomal protein S15a pseudogene 1 Neighboring gene KIZ antisense RNA 1 Neighboring gene VISTA enhancer hs914 Neighboring gene zinc finger protein 877, pseudogene Neighboring gene 5'-3' exoribonuclease 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Lupus nephritis susceptibility Loci in women with systemic lupus erythematosus.
GeneReviews: Not available
Retinitis pigmentosa 69
MedGen: C4014312 OMIM: 615780 GeneReviews: Not available
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Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102941, MGC141930, DKFZp586H021

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
centrosomal protein kizuna
Names
polo-like kinase 1 substrate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033122.2 RefSeqGene

    Range
    5103..125643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001163022.3NP_001156494.1  centrosomal protein kizuna isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK293166, BC045826, BC090879, DC386700
    Consensus CDS
    CCDS74707.1
    UniProtKB/Swiss-Prot
    Q2M2Z5
    Related
    ENSP00000478019.1, ENST00000620891.4
  2. NM_001163023.3NP_001156495.1  centrosomal protein kizuna isoform 3

    Status: REVIEWED

    Source sequence(s)
    AK293166, BC090879, BC105093
    Consensus CDS
    CCDS74708.1
    UniProtKB/Swiss-Prot
    Q2M2Z5
    Related
    ENSP00000480612.1, ENST00000616848.4
  3. NM_001276389.2NP_001263318.1  centrosomal protein kizuna isoform 4

    Status: REVIEWED

    Source sequence(s)
    AK293567, AL121759, BC090879, DC386700
    Consensus CDS
    CCDS74705.1
    UniProtKB/TrEMBL
    A0A087X251
    Related
    ENSP00000484706.1, ENST00000619574.4
  4. NM_001352434.2NP_001339363.1  centrosomal protein kizuna isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL110120, AL117332, AL121759, BC090879, KF459716
  5. NM_001352435.2NP_001339364.1  centrosomal protein kizuna isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL110120, AL117332, AL121759, BC090879, KF459716
  6. NM_001352436.2NP_001339365.1  centrosomal protein kizuna isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL110120, AL117332, AL121759, BC090879, KF459716
  7. NM_018474.6NP_060944.3  centrosomal protein kizuna isoform 1

    See identical proteins and their annotated locations for NP_060944.3

    Status: REVIEWED

    Source sequence(s)
    AK293166, BC090879, BC105093
    Consensus CDS
    CCDS74706.1
    UniProtKB/Swiss-Prot
    Q2M2Z5
    Related
    ENSP00000479542.1, ENST00000619189.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    21125975..21246622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529299.3XP_011527601.1  centrosomal protein kizuna isoform X3

  2. XM_017027952.2XP_016883441.1  centrosomal protein kizuna isoform X5

  3. XM_011529296.3XP_011527598.1  centrosomal protein kizuna isoform X1

  4. XM_011529297.3XP_011527599.1  centrosomal protein kizuna isoform X2

  5. XM_017027951.2XP_016883440.1  centrosomal protein kizuna isoform X4

RNA

  1. XR_937105.3 RNA Sequence

  2. XR_001754334.2 RNA Sequence

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