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ACOT13 acyl-CoA thioesterase 13 [ Homo sapiens (human) ]

Gene ID: 55856, updated on 12-Aug-2018

Summary

Official Symbol
ACOT13provided by HGNC
Official Full Name
acyl-CoA thioesterase 13provided by HGNC
Primary source
HGNC:HGNC:20999
See related
Ensembl:ENSG00000112304 MIM:615652; Vega:OTTHUMG00000014359
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HT012; THEM2; PNAS-27
Summary
This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]
Expression
Ubiquitous expression in kidney (RPKM 18.3), liver (RPKM 16.3) and 25 other tissues See more
Orthologs

Genomic context

See ACOT13 in Genome Data Viewer
Location:
6p22.3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (24667035..24705069)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (24667263..24705297)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene KIAA0319 Neighboring gene keratin 8 pseudogene 43 Neighboring gene tyrosyl-DNA phosphodiesterase 2 Neighboring gene chromosome 6 open reading frame 62 Neighboring gene uncharacterized LOC105374978 Neighboring gene adaptor related protein complex 3 subunit sigma 1 pseudogene Neighboring gene geminin, DNA replication inhibitor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Fatty Acyl-CoA Biosynthesis, organism-specific biosystem (from REACTOME)
    Fatty Acyl-CoA Biosynthesis, organism-specific biosystemFatty acyl-CoA biosynthesis involves following steps: -Palmitate synthesis catalyzed by Acetyl-CoA carboxylase and Fatty acid synthase-Conversion of palmitic acid to long chain fatty acids and-Conver...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Triglyceride Biosynthesis, organism-specific biosystem (from REACTOME)
    Triglyceride Biosynthesis, organism-specific biosystemThe overall process of triglyceride (triacylglycerol) biosynthesis consists of four biochemical pathways: fatty acyl-CoA biosynthesis, conversion of fatty acyl-CoA to phosphatidic acid, conversion of...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4961

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
acyl-CoA hydrolase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
acyl-CoA metabolic process TAS
Traceable Author Statement
more info
 
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein homotetramerization IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acyl-coenzyme A thioesterase 13
Names
hypothalamus protein HT012
thioesterase superfamily member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160094.1NP_001153566.1  acyl-coenzyme A thioesterase 13 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon and uses a distinct start codon, compared to variant (1). The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK309738, AL031775, CB852340, DB214267
    Consensus CDS
    CCDS54972.1
    UniProtKB/Swiss-Prot
    Q9NPJ3
    Related
    ENSP00000445552.1, ENST00000537591.5
    Conserved Domains (2) summary
    cd03443
    Location:5115
    PaaI_thioesterase; PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not ...
    pfam13622
    Location:3098
    4HBT_3; Thioesterase-like superfamily
  2. NM_018473.3NP_060943.1  acyl-coenzyme A thioesterase 13 isoform 1

    See identical proteins and their annotated locations for NP_060943.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    AL031775, BC000894, CB852340, DB214267
    Consensus CDS
    CCDS4558.1
    UniProtKB/Swiss-Prot
    Q9NPJ3
    Related
    ENSP00000230048.3, OTTHUMP00000016090, ENST00000230048.4, OTTHUMT00000040010
    Conserved Domains (1) summary
    cd03443
    Location:25138
    PaaI_thioesterase; PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    24667035..24705069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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