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ZC3H15 zinc finger CCCH-type containing 15 [ Homo sapiens (human) ]

Gene ID: 55854, updated on 7-Aug-2022

Summary

Official Symbol
ZC3H15provided by HGNC
Official Full Name
zinc finger CCCH-type containing 15provided by HGNC
Primary source
HGNC:HGNC:29528
See related
Ensembl:ENSG00000065548 MIM:619704; AllianceGenome:HGNC:29528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DFRP1; HT010; LEREPO4; MSTP012
Summary
Enables RNA binding activity and cadherin binding activity. Involved in positive regulation of GTPase activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 44.3), brain (RPKM 30.6) and 25 other tissues See more
Orthologs
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Genomic context

See ZC3H15 in Genome Data Viewer
Location:
2q32.1
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (186486260..186509361)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (186975546..186998651)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (187350987..187374088)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 28 pseudogene 3 Neighboring gene uncharacterized LOC105373785 Neighboring gene divergent-paired related homeobox pseudogene 1 Neighboring gene uncharacterized LOC124907920 Neighboring gene uncharacterized LOC107985784

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger CCCH domain-containing protein 15
Names
DRG family-regulatory protein 1
likely ortholog of mouse immediate early response erythropoietin 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018471.3NP_060941.2  zinc finger CCCH domain-containing protein 15

    See identical proteins and their annotated locations for NP_060941.2

    Status: VALIDATED

    Source sequence(s)
    AL040058, BC021102
    Consensus CDS
    CCDS42791.1
    UniProtKB/Swiss-Prot
    Q8WU90, Q9P079
    Related
    ENSP00000338788.6, ENST00000337859.11
    Conserved Domains (3) summary
    smart00356
    Location:99125
    ZnF_C3H1; zinc finger
    COG5252
    Location:1325
    COG5252; Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only]
    pfam16543
    Location:230312
    DFRP_C; DRG Family Regulatory Proteins, Tma46

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    186486260..186509361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    186975546..186998651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)