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rasgrp4 RAS guanyl releasing protein 4 [ Danio rerio (zebrafish) ]

Gene ID: 558453, updated on 25-Nov-2021

Summary

Official Symbol
rasgrp4provided by ZNC
Official Full Name
RAS guanyl releasing protein 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-050419-110
See related
Ensembl:ENSDARG00000061796
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-12o15.1
Orthologs
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Genomic context

See rasgrp4 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (35742576..35802483)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (35761575..35821475)
103 previous assembly Zv9 (GCF_000002035.4) 18 NC_007129.5 (34082431..34142319)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene inositol-trisphosphate 3-kinase Cb Neighboring gene ryanodine receptor 1b (skeletal) Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 1 Neighboring gene outer mitochondrial membrane lipid metabolism regulator OPA3

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lymph vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RAS guanyl-releasing protein 4; RAS guanyl-releasing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044862.1NP_001038327.1  RAS guanyl-releasing protein 4

    See identical proteins and their annotated locations for NP_001038327.1

    Status: PROVISIONAL

    Source sequence(s)
    CR377223
    UniProtKB/TrEMBL
    Q1L9A0
    Related
    ENSDARP00000082937.4, ENSDART00000088504.6
    Conserved Domains (5) summary
    cd06224
    Location:58162
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:194430
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00130
    Location:537586
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:473519
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:475524
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    35742576..35802483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173660.4XP_005173717.1  RAS guanyl-releasing protein 1 isoform X5

    See identical proteins and their annotated locations for XP_005173717.1

    Conserved Domains (5) summary
    cd06224
    Location:26130
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:162398
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00130
    Location:505554
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:441487
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:443492
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. XM_005173657.4XP_005173714.1  RAS guanyl-releasing protein 1 isoform X1

    Conserved Domains (5) summary
    cd06224
    Location:58162
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:194430
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00130
    Location:537586
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:473519
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:475524
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. XM_005173659.4XP_005173716.1  RAS guanyl-releasing protein 1 isoform X4

    Conserved Domains (5) summary
    cd06224
    Location:58162
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:194430
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00130
    Location:537586
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:473519
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:475524
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  4. XM_005173658.4XP_005173715.1  RAS guanyl-releasing protein 1 isoform X3

    Conserved Domains (5) summary
    cd06224
    Location:58162
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:194430
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00130
    Location:537586
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:473519
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:475524
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  5. XM_009293782.3XP_009292057.1  RAS guanyl-releasing protein 1 isoform X2

    Conserved Domains (5) summary
    cd06224
    Location:57161
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:193429
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00130
    Location:536585
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:472518
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:474523
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  6. XM_021467661.1XP_021323336.1  RAS guanyl-releasing protein 1 isoform X6

    Conserved Domains (5) summary
    cd06224
    Location:58162
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:194430
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00130
    Location:537586
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:465492
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:475524
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
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