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BRK1 BRICK1 subunit of SCAR/WAVE actin nucleating complex [ Homo sapiens (human) ]

Gene ID: 55845, updated on 4-Dec-2022

Summary

Official Symbol
BRK1provided by HGNC
Official Full Name
BRICK1 subunit of SCAR/WAVE actin nucleating complexprovided by HGNC
Primary source
HGNC:HGNC:23057
See related
Ensembl:ENSG00000254999 MIM:611183; AllianceGenome:HGNC:23057
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDS027; hHBrk1; C3orf10; HSPC300
Summary
Enables identical protein binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction and positive regulation of cellular component organization. Located in extracellular exosome. Part of SCAR complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 95.9), kidney (RPKM 81.0) and 25 other tissues See more
Orthologs
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Genomic context

See BRK1 in Genome Data Viewer
Location:
3p25.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (10115675..10127190)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (10107895..10119411)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (10157359..10168874)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene 3p25 FANCD2 Alu-mediated recombination region Neighboring gene FA complementation group D2 Neighboring gene CYCS pseudogene 11 Neighboring gene FANCD2 opposite strand Neighboring gene 3p25 BRK1 Alu-mediated recombination region Neighboring gene small nucleolar RNA U13 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SCAR complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein BRICK1
Names
BRICK1, SCAR/WAVE actin nucleating complex subunit
haematopoietic stem/progenitor cell protein 300

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018462.5NP_060932.2  protein BRICK1

    See identical proteins and their annotated locations for NP_060932.2

    Status: VALIDATED

    Source sequence(s)
    AY148219
    Consensus CDS
    CCDS54553.1
    UniProtKB/Swiss-Prot
    Q8WUW1, Q9P082
    Related
    ENSP00000432472.1, ENST00000530758.2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    10115675..10127190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    10107895..10119411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)