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ARHGAP15 Rho GTPase activating protein 15 [ Homo sapiens (human) ]

Gene ID: 55843, updated on 24-Nov-2020

Summary

Official Symbol
ARHGAP15provided by HGNC
Official Full Name
Rho GTPase activating protein 15provided by HGNC
Primary source
HGNC:HGNC:21030
See related
Ensembl:ENSG00000075884 MIM:610578
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BM046
Summary
RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in lymph node (RPKM 10.3), bone marrow (RPKM 9.8) and 18 other tissues See more
Orthologs

Genomic context

See ARHGAP15 in Genome Data Viewer
Location:
2q22.2-q22.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (143070973..143768352)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (143886899..144525921)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene stress induced phosphoprotein 1 pseudogene 1 Neighboring gene SFXN4 pseudogene 1 Neighboring gene kynureninase Neighboring gene uncharacterized LOC107985949 Neighboring gene MT-CYB pseudogene 11 Neighboring gene MT-ND6 pseudogene 11 Neighboring gene MT-ND5 pseudogene 24 Neighboring gene MT-ND4 pseudogene 22 Neighboring gene MT-ATP6 pseudogene 5 Neighboring gene MT-CO3 pseudogene 5 Neighboring gene MT-ND3 pseudogene 9 Neighboring gene MT-CO2 pseudogene 5 Neighboring gene VISTA enhancer hs675 Neighboring gene uncharacterized LOC101928361 Neighboring gene ARHGAP15 antisense RNA 1 Neighboring gene uncharacterized LOC101928386 Neighboring gene glycosyltransferase like domain containing 1 Neighboring gene skeletal muscle cis-regulatory module overlapping ZEB2 Neighboring gene zinc finger E-box binding homeobox 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
GeneReviews: Not available
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
GeneReviews: Not available
Genome-wide association study of selenium concentrations.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 15
Names
rho-type GTPase-activating protein 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018460.4NP_060930.3  rho GTPase-activating protein 15

    See identical proteins and their annotated locations for NP_060930.3

    Status: VALIDATED

    Source sequence(s)
    BC038976, BP299206
    Consensus CDS
    CCDS2184.1
    UniProtKB/Swiss-Prot
    Q53QZ3
    Related
    ENSP00000295095.6, ENST00000295095.11
    Conserved Domains (3) summary
    cd04403
    Location:279465
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:81190
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:80188
    PH; PH domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    143070973..143768352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511479.2XP_011509781.1  rho GTPase-activating protein 15 isoform X1

    See identical proteins and their annotated locations for XP_011509781.1

    UniProtKB/Swiss-Prot
    Q53QZ3
    Conserved Domains (3) summary
    cd04403
    Location:279465
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:81190
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:80188
    PH; PH domain
  2. XM_017004499.2XP_016859988.1  rho GTPase-activating protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q53QZ3
    Conserved Domains (3) summary
    cd04403
    Location:279465
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:81190
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:80188
    PH; PH domain
  3. XM_017004500.2XP_016859989.1  rho GTPase-activating protein 15 isoform X3

  4. XM_011511481.2XP_011509783.1  rho GTPase-activating protein 15 isoform X2

    Conserved Domains (3) summary
    cd13233
    Location:81190
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:80188
    PH; PH domain
    cl02570
    Location:279421
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  5. XM_011511482.2XP_011509784.1  rho GTPase-activating protein 15 isoform X4

    Conserved Domains (3) summary
    cd13233
    Location:81190
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:80188
    PH; PH domain
    cl02570
    Location:279414
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  6. XM_011511484.1XP_011509786.1  rho GTPase-activating protein 15 isoform X6

    Conserved Domains (3) summary
    cd13233
    Location:81190
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:80188
    PH; PH domain
    cl02570
    Location:279334
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  7. XM_017004501.1XP_016859990.1  rho GTPase-activating protein 15 isoform X7

  8. XM_011511483.1XP_011509785.1  rho GTPase-activating protein 15 isoform X5

    Conserved Domains (2) summary
    cd04403
    Location:201387
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cl17171
    Location:49112
    PH-like; Pleckstrin homology-like domain
  9. XM_024453001.1XP_024308769.1  rho GTPase-activating protein 15 isoform X8

    Conserved Domains (1) summary
    cd04403
    Location:45231
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
  10. XM_024453000.1XP_024308768.1  rho GTPase-activating protein 15 isoform X8

    Conserved Domains (1) summary
    cd04403
    Location:45231
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

RNA

  1. XR_001738850.1 RNA Sequence

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