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WWC3 WWC family member 3 [ Homo sapiens (human) ]

Gene ID: 55841, updated on 1-Jun-2020

Summary

Official Symbol
WWC3provided by HGNC
Official Full Name
WWC family member 3provided by HGNC
Primary source
HGNC:HGNC:29237
See related
Ensembl:ENSG00000047644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BM042
Summary
This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in lung (RPKM 15.2), placenta (RPKM 10.3) and 25 other tissues See more
Orthologs

Genomic context

See WWC3 in Genome Data Viewer
Location:
Xp22.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (10015254..10144474)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (9983795..10112518)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene shroom family member 2 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 33 Neighboring gene claudin 34 Neighboring gene chloride voltage-gated channel 4 Neighboring gene midline 1 Neighboring gene RNA, U6 small nuclear 800, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1280

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
molecular adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021467.2 RefSeqGene

    Range
    5001..133724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015691.4NP_056506.2  protein WWC3

    See identical proteins and their annotated locations for NP_056506.2

    Status: VALIDATED

    Source sequence(s)
    AC002359, AC002364, AC002365, AC121345
    Consensus CDS
    CCDS14136.1
    UniProtKB/Swiss-Prot
    Q9ULE0
    Related
    ENSP00000370242.4, ENST00000380861.8
    Conserved Domains (2) summary
    cd08680
    Location:602725
    C2_Kibra; C2 domain found in Human protein Kibra
    pfam05615
    Location:4119
    THOC7; Tho complex subunit 7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    10015254..10144474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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